Rapid screening of abused drugs by direct analysis in real time (DART) coupled to time-of-flight mass spectrometry (TOF-MS) combined with ion mobility spectrometry (IMS)

Lian, Ru; Wu, Zhongping; Lv, Xiaobao; Rao, Yulan; Li, Haiyang; Li, Jinghua; Wang, Rong; Ni, Chunfang; Zhang, Yurong

doi:10.1016/j.forsciint.2017.07.010

Cited by 34 publications

(15 citation statements)

References 27 publications

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“…Most of the methods for detecting fentanyl citrate are either time-consuming or required complex or expensive instrumentation. Gold standard methods for analyzing samples for fentanyl contamination are mass spectrometry based, which are limited to use in a laboratory setting. , More portable rapid, screening technologies include ion mobility spectroscopy, which offers rapid, sensitive fentanyl detection but can be confounded by complex mixtures commonly encountered in-the-field. − Thermal desorption direct analysis in real-time mass spectrometry demonstrates greater resilience to mixtures but is not yet fully portable and thus currently limited to use in mobile laboratories, emergency vehicles, and hospitals . Commercial hand-held systems are available for Raman spectroscopy (TrueNarc) and spatially offset Raman spectroscopy (Agilent Resolve) for drug analysis in-field.…”

Section: Introductionmentioning

confidence: 99%

Ionic Liquid-Modified Disposable Electrochemical Sensor Strip for Analysis of Fentanyl

et al. 2019

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The increasing prevalence of fentanyl and its analogues as contaminating materials in illicit drug products presents a major hazard to first responder and law enforcement communities. Electrochemical techniques have the potential to provide critical information to these personnel via rapid, facile field detection of these materials. Here we demonstrate the use of cyclic square wave voltammetry (CSWV) with screen-printed carbon electrodes (SPCE), modified with the room temperature ionic liquid (RTIL) 1-butyl-1-methylpyrrolidinium bis-(trifluoromethylsulfonyl)imide [C 4 C 1 pyrr][NTf 2 ], toward such rapid "on-the-spot" fentanyl detection. This CSWV-based disposable sensor strip system provides an information-rich electrochemical fingerprint of fentanyl, composed of an initial oxidation event at +0.556 V (vs Ag/ AgCl) and a reversible reduction and oxidation reaction at −0.235 and −0.227 V, respectively. The combined current and potential characteristics of these anodic and cathodic fentanyl peaks, generated using two CSWV cycles, thus lead to a distinct electrochemical signature. This CSWV profile facilitates rapid (1 min) identification of the target opioid at micromolar concentrations in the presence of other cutting agents commonly found in illicit drug formulations. The new protocol thus holds considerable promise for rapid decentralized fentanyl detection at the "point of need".

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Section: Introductionmentioning

confidence: 99%

Ionic Liquid-Modified Disposable Electrochemical Sensor Strip for Analysis of Fentanyl

et al. 2019

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“…A high voltage supply generates the electromagnetic field, and a counter-current gas flow can increment the resolution. IMS can employ different ion sources, such as LTP [78] and DART [79]. In addition, the coupling to separation units is possible [80].…”

Section: Ion Transfer and Ion Mobility Spectrometry (Ims)mentioning

confidence: 99%

Build, Share and Remix: 3D Printing for Speeding Up the Innovation Cycles in Ambient Ionisation Mass Spectrometry (AIMS)

et al. 2022

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Ambient ionisation mass spectrometry (AIMS) enables studying biological systems in their native state and direct high-throughput analyses. The ionisation occurs in the physical conditions of the surrounding environment. Simple spray or plasma-based AIMS devices allow the desorption and ionisation of molecules from solid, liquid and gaseous samples. 3D printing helps to implement new ideas and concepts in AIMS quickly. Here, we present examples of 3D printed AIMS sources and devices for ion transfer and manipulation. Further, we show the use of 3D printer parts for building custom AIMS sampling robots and imaging systems. Using 3D printing technology allows upgrading existing mass spectrometers with relatively low cost and effort.

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“…本课题组 [63] [32] 微波诱导等离子体解吸/离子化 MPT Microwave plasma torch [33] 微波等离子体炬 MFGDP Micro-fabricated glow discharge plasma [34] 微型辉光放电等离子体 MPPDI Micro plasma probe desorption/ionization [39] 微型等离子体探针解吸/离子化 LS-APAG Liquid sampling-atmospheric pressure afterglow micro plasma ionization [40] 液体采样大气压辉光微型等离子体离子源 NAIMS Nanotip ambient ionization mass spectrometry [42] 纳米探针常压离子化质谱技术 AFI Ambient flame ionization [46] 常压火焰离子化 CFI Carbon fiber ionization [54] 碳纤维离子化 http://engine.scichina.com/doi/10.1360/N032017-00125 的等离子体电离技术, 大大减少了样品前处理所耗费的精力和时间, 比较适合对法庭科学领域的有毒有害物质开展快速筛查工作. 张玉荣等 [66] 最近报道了利用 DART-TOF-MS结合离子漂移谱来快速筛查毒品. 赵志东 [67] 综述了实时DART-MS新技术在法庭科学中的应用, 包括墨水字迹和胶带等微量物证.…”

Section: 解吸/离子化中的一些特殊的化学反应unclassified

New plasma principe-based desorption/ionization technologies for organic mass spectrometry

2017

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In recent years, with the deep understanding of the important role of plasma in desorption and ionization of organic compounds during mass spectrometric analysis, various ionization techniques based on plasma have been emerging. New plasma-principle based desorption/ionization technologies for organic mass spectrometry have not only greatly improved the speed and sensitivity of analysis than traditional ionization methods, but also it is more important that the new desorption and ionization technologies based on plasma have advantages for in-situ sample analyses. This review focuses on the latest developments of the ionization technologies based plasma principle for organic mass spectrometry in recent three years, especially the flame ionization and carbon fiber ionization technologies developed recently by our group. The principles of these two methods are closely related to the plasma-based desorption and ionization techniques, and these two kinds of technology provide some new options for the development of new research methods and new ionization devices.

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Rapid screening of abused drugs by direct analysis in real time (DART) coupled to time-of-flight mass spectrometry (TOF-MS) combined with ion mobility spectrometry (IMS)

Cited by 34 publications

References 27 publications

Ionic Liquid-Modified Disposable Electrochemical Sensor Strip for Analysis of Fentanyl

Ionic Liquid-Modified Disposable Electrochemical Sensor Strip for Analysis of Fentanyl

Build, Share and Remix: 3D Printing for Speeding Up the Innovation Cycles in Ambient Ionisation Mass Spectrometry (AIMS)

New plasma principe-based desorption/ionization technologies for organic mass spectrometry

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