Rapid quantitative detection of capsaicinoids in serum based on an electrochemical immunosensor with a dual-signal amplification strategy

Zhao, Qingxue; Wu, Yuxiang; Shi, Xiaojie; Dong, Haowei; Liu, Huimin; Zheng, Yan; Yang, Qingqing; Sun, Xia; Guo, Yemin; Zhao, Shancang

doi:10.1007/s10008-020-04833-6

Cited by 8 publications

(5 citation statements)

References 33 publications

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“…Analysis of electrochemical immunosensor.-Characterization of the prepared materials.-The preparation of nanomaterials played an important role in the construction of immunosensors. 34 The morphology and structure of the prepared nanomaterials were characterized by SEM. It could be seen from Fig.…”

Section: Resultsmentioning

confidence: 99%

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Competitive Electrochemical Immunosensor for Detection of Capsaicinoids in Edible Vegetable Oil Based on Computer Aided Molecular Modeling

Sun¹,

Zhao²,

Zha³

et al. 2022

J. Electrochem. Soc.

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The adulteration of edible vegetable oil is a serious threat to the health of consumers. Previous studies have shown that capsaicinoids could be used as a marker of adulteration to identify vegetable oils. The key sites of antibody and capsaicinoids were analyzed by computer aided molecular modeling, which provided a basis for the selection of modified material and the implanting of antigen and antibody on the electrode in the subsequent construction of the electrochemical immunosensor. Simultaneously, it was determined that the different forces between capsaicinoids and antibody were the important reason for the differences in sensitivity of capsaicinoids. On this basis, combined with the good conductivity and excellent redox characteristic of Fe3O4NPs@CeO2, a competitive immunosensor was constructed. Under the optimal conditions, the proposed immunosensor provided a linear range of 10-3 to 104 ng/mL with a detection limit of 0.33 pg/mL. This study may broaden the interaction between capsaicinoids and antibody, encourage the design of novel performance-enhanced antibody, and provide a new method for the detection of capsaicinoids.

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Section: Resultsmentioning

confidence: 99%

“…EIS is often used to further characterize the electron transfer characteristics of different modified electrodes. 34 The detection environment was the same as CV and DPV, the semicircle diameter of the Nyquist plot reflected the electron transfer resistance. As shown in Fig.…”

Section: Resultsmentioning

confidence: 99%

Competitive Electrochemical Immunosensor for Detection of Capsaicinoids in Edible Vegetable Oil Based on Computer Aided Molecular Modeling

Sun¹,

Zhao²,

Zha³

et al. 2022

J. Electrochem. Soc.

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“…Under these improved circumstances, Zhao et al achieved an exceptionally low LOD and an extensive linear concentration range. 38 In this context, many of the electrochemical sensors proposed for the determination of capsaicin have proven to be fast, simple, costeffective, and with reliable outcomes such as good sensitivity, selectivity, stability, wide linearity, and low LOD. The discussed works feature newly developed sensors or classical ones modified to achieve the same or even better analytical capabilities of the electrodes compared with other testing methods.…”

Section: Electrochemical Sensors Used For the Determination Of Topica...mentioning

confidence: 99%

Review—Novel Trends in the Determination of Pharmaceutical Compounds Commonly Found in Topical Treatments using Electrochemical Sensing Approaches

Tuchiu,

Stefan-van Staden,

van Staden

2024

J. Electrochem. Soc.

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Topical treatments rely on drugs that play a crucial role in addressing skin and mucous membrane disorders. Therefore, it is highly needed to utilize accurate analytical techniques that can determine the concentration of these chemicals in various sample matrices, including pharmaceuticals, food, and water. Currently, electrochemical sensors are predominantly used in specific fields such as biomedical, industrial, and environmental monitoring, while they have not yet been incorporated into the pharmaceutical manufacturing industry. However, electrochemical methods employing an expanding range of sensors provide a reliable, cost-effective, and efficient substitute for classical analytical methods. Their potential is highly favorable, offering possibilities for simultaneous determination, miniaturization, and real-time on-site monitoring. This work covers numerous sensors designed between 2020 and 2023 for the determination of topical drugs, highlighting their respective benefits and drawbacks while illuminating emerging trends. Moreover, it discusses the correlation between the used materials and the ease of manufacturing, to the achieved results, including dynamic range, detection limit, sensitivity, and selectivity. This work aims to serve as a valuable resource for researchers, engineers, and policymakers in the evolving field of electrochemical sensing by providing guidance and facilitating decision-making, which could lead to significant innovations in sensor technology.

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“…55 The insulated antibody molecules can hinder the electron transfer at the electrode/electrolyte interface. 56,57 The antibody and N-gene formed due to the specific binding between them, hampering the electron transfer from [Fe (CN) 6 ] 3−/4− ions to the electrode. 58 The CV measurements in Fig.…”

Section: Sensing Performances Of the Tapp-dpdd-pop-based Immunosensormentioning

confidence: 99%

Construction of bifunctional electrochemical biosensors for the sensitive detection of the SARS-CoV-2 N-gene based on porphyrin porous organic polymers

et al. 2022

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Rapid quantitative detection of capsaicinoids in serum based on an electrochemical immunosensor with a dual-signal amplification strategy

Cited by 8 publications

References 33 publications

Competitive Electrochemical Immunosensor for Detection of Capsaicinoids in Edible Vegetable Oil Based on Computer Aided Molecular Modeling

Competitive Electrochemical Immunosensor for Detection of Capsaicinoids in Edible Vegetable Oil Based on Computer Aided Molecular Modeling

Review—Novel Trends in the Determination of Pharmaceutical Compounds Commonly Found in Topical Treatments using Electrochemical Sensing Approaches

Construction of bifunctional electrochemical biosensors for the sensitive detection of the SARS-CoV-2 N-gene based on porphyrin porous organic polymers

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