Rapid metabolic shifts occur during the transition between hunger and satiety in Drosophila melanogaster

Abstract

Metabolites are active controllers of cellular physiology, but their role in complex behaviors is less clear. Here we report metabolic changes that occur during the transition between hunger and satiety in Drosophila melanogaster . To analyze these data in the context of fruit fly metabolic networks, we developed Flyscape, an open-access tool. We show that in response to eating, metabolic profiles change in quick, but distinct ways in the heads and bodies. Consumption of a high sugar diet dulls the metabolic and behavioral differences between the fasted and fed state, and reshapes the way nutrients are utilized upon eating. Specifically, we found that high dietary sugar increases TCA cycle activity, alters neurochemicals, and depletes 1-carbon metabolism and brain health metabolites N-acetyl-aspartate and kynurenine. Together, our work identifies the metabolic transitions that occur during hunger and satiation, and provides a platform to study the role of metabolites and diet in complex behavior.

Resilience in a Natural Model of Metabolic Dysfunction Through Changes in Longevity and Ageing-Related Metabolites

“…Recent work in invertebrates, rodents, and zebrafish have increased our mechanistic understanding of the roles of metabolism in cell cycle, tissue growth, and aging (7)(8)(9)(10). Other studies have characterized metabolic responses to environmental and intrinsic challenges, such as diet and disease (11,12). Given that cellular metabolism is highly conserved, profiles in these studies have confirmed signatures of disease progression, characterized drug responses, and identified novel metabolites and pathways for future exploration (13).…”

Transcriptome Analysis of NPFR Neurons Reveals a Connection Between proteome Diversity and Social Behavior

“…The fruit fly Drosophila melanogaster is a useful model organism for investigating the genetic underpinnings of motivational behaviors, owing to variety of tools for neuro-genetic manipulations, together with the fact that flies exhibit several forms of behaviors that are shaped by motivation 29,[31][32][33][34][35][36][37][38][39][40][41] . One of the systems that encodes internal states and dictates motivational drives, and consequently, behavioral choices in Drosophila is the Neuropeptide F/Neuropeptide F receptor [42][43][44][45][46][47][48][49][50][51][52][53][54] .…”

Aumento Da Ingestão De Açúcar Afeta a Capacidade Da Drosophila Melanogaster Sobreviver Em Condições Críticas / Increased Sugar Intake Affects the Drosophila Melanogaster Ability to Survive in Critical Conditions

“…O consumo de uma dieta rica em açúcar diminui as diferenças metabólicas e comportamentais entre os estados jejum e alimentado, e remodela a forma como os nutrientes são utilizados na alimentação (WILINSKI et al 2019). Além disso, o excesso de açúcar na dieta inibe o fator de transcrição dFOXO (DOBSON et al, 2016), que controla o envelhecimento em Drosophila melanogaster (HWANGBO et al, 2004) e é crucial para regular alterações transcricionais desenvolvidas no tempo de vida da mosca.…”