Rapid Low-Cost Microfluidic Detection in Point of Care Diagnostics

Raju, Srikrishnan P.; Chu, Xiaogang

doi:10.1007/s10916-018-1043-1

Cited by 10 publications

(6 citation statements)

References 13 publications

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“…Technologies for personalized care, such as cheaper physiological signal monitoring systems, can also reduce inequalities in healthcare [101]. Other diagnostic-related frugal solutions can be cited, such as solutions for detecting biological fluids [102] and those based on mobile technologies [80].…”

Section: Impacts On Social Opportunitiesmentioning

confidence: 99%

Pro-Poor Innovations to Promote Instrumental Freedoms: A Systematic Literature Review

Mariano

Silva

2021

Sustainability

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Through a systematic literature review, this article aims to evaluate the impacts of various concepts of pro-poor innovations (PPI) on the five instrumental freedoms in Amartya Sen’s Capability Approach. For this, 165 articles were analysed to summarize the main influences of the pro-poor innovation on each type of instrumental freedom: political freedoms, economic facilities, transparency guarantees, social opportunities, and protective security. In general, the results indicate a positive influence of the innovation concepts for distinct types of freedom, with emphasis on the expansion of social opportunities and economic facilities.

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Section: Impacts On Social Opportunitiesmentioning

confidence: 99%

Pro-Poor Innovations to Promote Instrumental Freedoms: A Systematic Literature Review

Mariano

Silva

2021

Sustainability

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“…Microfluidic technology has emerged as a transformative tool in the realm of food safety, offering unprecedented precision and efficiency in the detection of various analytes 17,18 . Microfluidics involves the controlled manipulation of minute volumes of fluids within the microscale or smaller, enabling the integration of diverse analytical processes on a single, miniaturized platform 19–21 . The fundamental principles governing microfluidics leverage the inherent properties of fluids at the microscale governed by capillary forces and laminar flow 22 .…”

Section: Introductionmentioning

confidence: 99%

“… 17 , 18 Microfluidics involves the controlled manipulation of minute volumes of fluids within the microscale or smaller, enabling the integration of diverse analytical processes on a single, miniaturized platform. 19 , 20 , 21 The fundamental principles governing microfluidics leverage the inherent properties of fluids at the microscale governed by capillary forces and laminar flow. 22 This technology excels in biosensing applications by facilitating rapid and highly sensitive analyses through reduced sample volumes and improved reaction kinetics, acting as a small “lab on a chip”.…”

Section: Introductionmentioning

confidence: 99%

Ensuring food safety: Microfluidic‐based approaches for the detection of food contaminants

Kasputis,

Hosmer,

et al. 2024

Analytical Science Advances

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Detecting foodborne contamination is a critical challenge in ensuring food safety and preventing human suffering and economic losses. Contaminated food, comprising biological agents (e.g. bacteria, viruses and fungi) and chemicals (e.g. toxins, allergens, antibiotics and heavy metals), poses significant risks to public health. Microfluidic technology has emerged as a transformative solution, revolutionizing the detection of contaminants with precise and efficient methodologies. By manipulating minute volumes of fluid on miniaturized systems, microfluidics enables the creation of portable chips for biosensing applications. Advancements from early glass and silicon devices to modern polymers and cellulose‐based chips have significantly enhanced microfluidic technology, offering adaptability, flexibility, cost‐effectiveness and biocompatibility. Microfluidic systems integrate seamlessly with various biosensing reactions, facilitating nucleic acid amplification, target analyte recognition and accurate signal readouts. As research progresses, microfluidic technology is poised to play a pivotal role in addressing evolving challenges in the detection of foodborne contaminants. In this short review, we delve into various manufacturing materials for state‐of‐the‐art microfluidic devices, including inorganics, elastomers, thermoplastics and paper. Additionally, we examine several applications where microfluidic technology offers unique advantages in the detection of food contaminants, including bacteria, viruses, fungi, allergens and more. This review underscores the significant advancement of microfluidic technology and its pivotal role in advancing the detection and mitigation of foodborne contaminants.

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“…Access to clinical diagnosis is limited in low-resource areas. Even in developed countries, rural areas may have insufficient health screening and disease prevention services [8]. Therefore, developing portable, inexpensive medical inspection equipment for field testing or self-testing at home is of great practical significance.…”

Section: Introductionmentioning

confidence: 99%

Microfluidic Point-of-Care (POC) Devices in Early Diagnosis: A Review of Opportunities and Challenges

Yang

Zhang

et al. 2022

Sensors

110

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The early diagnosis of infectious diseases is critical because it can greatly increase recovery rates and prevent the spread of diseases such as COVID-19; however, in many areas with insufficient medical facilities, the timely detection of diseases is challenging. Conventional medical testing methods require specialized laboratory equipment and well-trained operators, limiting the applicability of these tests. Microfluidic point-of-care (POC) equipment can rapidly detect diseases at low cost. This technology could be used to detect diseases in underdeveloped areas to reduce the effects of disease and improve quality of life in these areas. This review details microfluidic POC equipment and its applications. First, the concept of microfluidic POC devices is discussed. We then describe applications of microfluidic POC devices for infectious diseases, cardiovascular diseases, tumors (cancer), and chronic diseases, and discuss the future incorporation of microfluidic POC devices into applications such as wearable devices and telemedicine. Finally, the review concludes by analyzing the present state of the microfluidic field, and suggestions are made. This review is intended to call attention to the status of disease treatment in underdeveloped areas and to encourage the researchers of microfluidics to develop standards for these devices.

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Rapid Low-Cost Microfluidic Detection in Point of Care Diagnostics

Cited by 10 publications

References 13 publications

Pro-Poor Innovations to Promote Instrumental Freedoms: A Systematic Literature Review

Pro-Poor Innovations to Promote Instrumental Freedoms: A Systematic Literature Review

Ensuring food safety: Microfluidic‐based approaches for the detection of food contaminants

Microfluidic Point-of-Care (POC) Devices in Early Diagnosis: A Review of Opportunities and Challenges

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