Rapid identification of cytotoxic alkenyl catechols in Semecarpus anacardium using bioassay-linked high performance liquid chromatography-electrospray/mass spectrometric analysis

Modulation of oxidative/nitrosative stress and mitochondrial protective effect of Semecarpus anacardium in diabetic rats

“…It is non‐toxic up to 2000 mg/kg body weight. TLC, HPLC and HPTLC analysis of the nut and milk extract confirmed the presence of the above compounds [15–19] . The extract also possesses antioxidant, anti‐inflammatory, hypoglycaemic, [20] antiarthitic and anticancer actitivies [21] .…”

Identification of urushiols as the major active principle of the Siddha herbal medicineSemecarpusLehyam: Anti-tumor agents for the treatment of breast cancer

“…Their anti-tumor effect against murine P388 lyphocytic leukemia (Indap & Gokhale 1983) as well as against nasopharyngeal carcinoma (Hembree et al, 1978) have been described; however, in the older study, compounds ( 1 ) and ( 2 ) were found to be inactive against P388 leukemia (Hembree et al, 1978). These alkenyl catechols were also identified as probably being the cytotoxic constituents of a petroleum ether extract of S. anacardium (Shin et al, 1999) and were found inhibitory against Clostridium tetani (Lamture et al, 1982). The urushiols identified here, along with various closely related similar compounds, are most famous as contact allergens from the Anacardiaceae Rhus radicans (poison ivy) and Rhus toxidendron (poison oak), both frequently found woody vines and low growing shrubs, respectively, in the USA.…”

Apoptotic and cytotoxic effect of Semecarpus anacardium Linn nut milk extract on MCF-7 breast cancer cells

“…Semecarpus anacardium Linn nut milk extract is one such drug that has high therapeutic value in Siddha system of medicine. Phytochemical analysis and HPTLC studies have confirmed the presence of trihydroxyflavone, semecarpol, anacardoside, and bhilawanols as the major constituents present in the nut milk extract (Aravind et al 2008;Shin et al 1999;Nair et al 2009). Studies carried out in our laboratory have established its therapeutic properties, viz, antioxidant, antiinflammatory, immunomodulatory, antiarthritic (Ramprasath et al 2006), antidiabetic (Haseena Banu et al 2011), antihypercholesterolemic (Haseena Banu et al 2013, and cardioprotective (Suganthi et al 2014) effects.…”