2008
DOI: 10.1001/archderm.144.4.560
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Rapid Enlargement of a Malignant Melanoma in a Child With Vitiligo Vulgaris After Application of Topical Tacrolimus

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Cited by 13 publications
(6 citation statements)
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“…Topical tacrolimus is as effective in children as class I topical corticosteroid clobetasol [40]. A single study of enlargement of a melanoma after accidental tacrolimus application supports full body examination prior to prescription of this agent in children with vitiligo, to be sure they do not have a melanoma which caused the onset of vitiligo [59].…”
Section: Topical Calcineurin Inhibitorsmentioning
confidence: 84%
“…Topical tacrolimus is as effective in children as class I topical corticosteroid clobetasol [40]. A single study of enlargement of a melanoma after accidental tacrolimus application supports full body examination prior to prescription of this agent in children with vitiligo, to be sure they do not have a melanoma which caused the onset of vitiligo [59].…”
Section: Topical Calcineurin Inhibitorsmentioning
confidence: 84%
“…They are less effective in acral lesions and in adults [41,43]. Avoidance of application over atypical pigmented lesions is recommended [45]. Absorption through intact skin is felt to be very limited in patients with vitiligo and is limited even in pediatric atopic dermatitis where the skin barrier is impaired [46][47][48].…”
Section: Topical Calcineurin Inhibitorsmentioning
confidence: 99%
“…205,215 With respect to topical therapy, moderate to high potency topical corticosteroids are efficacious in children, but their use may be associated with some systemic absorption. 218 Pimecrolimus cream has been used for eyebrow/eyelid and genital lesions. 217 Rapid enlargement of a malignant melanoma occurred in a child with vitiligo after the application of topical tacrolimus.…”
Section: Treatment Of Vitiligomentioning
confidence: 99%