Rapid Effects of Estrogen or Progesterone on the Amphetamine-Induced Increase in Striatal Dopamine Are Enhanced by Estrogen Priming

Becker, Jill B.; Rudick, Charles N.

doi:10.1016/s0091-3057(99)00091-x

Cited by 177 publications

(157 citation statements)

References 43 publications

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“…The effect of E on acquisition of cocaine self-administration may be mediated by its wellcharacterized actions on dopamine (DA) neurotransmission (Becker et al, 1981;Di Paolo et al, 1985;Becker et al, 1986;Becker, 1990b, a;Di Paolo, 1994;Thompson et al, 1995;Xiao et al, 1997;Becker et al, 1999;Becker et al, 2001). Acute E increases stimulated DA release in striatum and nucleus accumbens (Becker, 1990b, a;Becker et al, 1999;Becker et al, 2001) and enhances DA reuptake in nucleus accumbens (Thompson et al, 1995).…”

Section: Discussionmentioning

confidence: 99%

“…Acute E increases stimulated DA release in striatum and nucleus accumbens (Becker, 1990b, a;Becker et al, 1999;Becker et al, 2001) and enhances DA reuptake in nucleus accumbens (Thompson et al, 1995). Importantly, there is an inverted U-shaped curve dose-response for the effect of E on amphetaminestimulated DA release in vitro, where physiological doses enhance DA release and supraphysiological doses do not (Becker, 1990a).…”

Section: Discussionmentioning

confidence: 99%

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Acquisition of cocaine self-administration in ovariectomized female rats: Effect of estradiol dose or chronic estradiol administration

Becker

2008

Drug and Alcohol Dependence

123

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This study was conducted to investigate whether the dose of estradiol (E) administered acutely, or chronic delivery of one dose of E impacts acquisition and subsequent cocaine self-administration in ovariectomized (OVX) female rats. Five groups of female rats were compared: OVX females treated with 0, 1, 2, or 5 µg 17 β-E, 30 min prior to the self-administration session, and OVX rats that received a 1.5 mg E pellet (designed to chronically release 25 µg E/d X 60 d) implanted 1 week before cocaine self-administration initiation. Rats were tested in 1 hr sessions on a FR1 schedule with the dose of cocaine increasing every week (testing occurred 5 day/wk; doses: 0.2, 0.3, 0.4, 0.5 and 0.75 mg/kg/ infusion). We report that OVX rats treated with 2 µg E acquired self-administration more rapidly than all of the other groups, and animals that received 1 or 2 µg E self-administered significantly more cocaine compared to OVX+vehicle at 0.3 and 0.4 mg/kg/infusion. In contrast, OVX rats given 5 µg E acutely, or chronic E via slow-release pellets did not take more cocaine than the OVX+vehicle group at any time point. Physiological serum concentrations of E were seen with 1 or 2 µg E, but 5 µg E and the E pellet produced supra-physiological concentrations. These results suggest an inverted U-shaped dose-response curve for the effect of E on acquisition of cocaine self-administration.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Acquisition of cocaine self-administration in ovariectomized female rats: Effect of estradiol dose or chronic estradiol administration

Becker

2008

Drug and Alcohol Dependence

123

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“…Estradiol has been shown to influence DA activity in brain regions that are important in mediating drug reward. Estradiol increases AMPH-stimulated DA release from the striatum (Castner et al, 1993;Becker and Rudick, 1999) and attenuates DA reuptake in the nucleus accumbens (Thompson, 1999). Although estradiol affects DA-mediated behaviors and DA neurotransmission in females, it does not appear to do so in males.…”

Section: Effects Of Gonadal Hormones On Male Cocaine Self-administrationmentioning

confidence: 96%

“…We did not test a progesterone-only group because in previous experiments the administration of progesterone alone did not influence psychomotor stimulant-induced behavior (Becker and Rudick, 1999;Disshon et al, 1998;Peris et al, 1991;Perrotti et al, 2001;Quinones-Jenab et al, 2000). For example, in OVX rats, hormone replacement with estradiol alone, but not progesterone alone, resulted in greater cocaine-evoked hyperactivity than was observed in nontreated OVX animals (Sell et al, 2000).…”

Section: Experimental Designmentioning

confidence: 99%

Sex Differences and Hormonal Influences on Acquisition of Cocaine Self-Administration in Rats

Jackson

Robinson

Becker

2005

Neuropsychopharmacol

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282

272

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Men and women differ in their response to cocaine, and a woman's response varies with the menstrual cycle. For example, women have greater subjective responses to cocaine in the follicular phase of the menstrual cycle when estradiol is predominant, than they do during the luteal phase when both estradiol and progesterone are elevated. Similarly, female rats show significantly more cocaine-induced locomotor behavior and cocaine self-administration during behavioral estrus, shortly after estradiol peaks, than during other stages of the cycle, and estradiol administration to ovariectomized (OVX) females enhances the acquisition of cocaine self-administration. The purpose of this study was to expand upon these findings by studying the effects of progesterone administration to females, and estradiol administration to males, on acquisition of cocaine self-administration. We report here that there are both sex differences in and effects of circulating ovarian hormones on acquisition of cocaine self-administration. We demonstrate that although estradiol administration enhances acquisition of cocaine self-administration in OVX female rats, concurrent administration of progesterone with estradiol inhibits this effect of estradiol. In a separate experiment, we demonstrate that estradiol administration does not enhance acquisition of cocaine self-administration in castrated male rats. We conclude that (1) there is a sex difference in the effects of estradiol on cocaine selfadministration: it facilitates acquisition in female, but not male rats; and that (2) in females concurrent progesterone treatment counteracts the facilitory effect of estradiol on cocaine self-administration.

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“…Moreover, sex hormones also affect behavioral responses to drugs such as amphetamine and cocaine. [3,4,21] Despite the known influences of female sex hormones on TBI pathophysiology and modulation of DA systems, no studies exist evaluating how gender influences the efficacy of DA agonists in promoting recovery. Therefore, the primary purpose of this study was to evaluate the effectiveness of MPH in improving recovery after CCI injury in both male and female rats and whether or not differences occur between gender groups with respect to effectiveness and behavioral sensitivity with daily treatment.…”

Section: Introductionmentioning

confidence: 99%

Gender associations with chronic methylphenidate treatment and behavioral performance following experimental traumatic brain injury

Wagner

Kline

Ren

et al. 2007

Behavioural Brain Research

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Evidence suggests that dopamine (DA) agonists improve cognition after traumatic brain injury (TBI). Methylphenidate (MPH) is a DA agonist that blocks the dopamine transporter (DAT). Moreover, female sex hormones modulate DAT expression. Therefore, the purpose of this study was to evaluate how MPH affects behavioral performance in male and female rats. Under anesthesia, rats underwent either controlled cortical impact (CCI) or sham injury operations. Beginning post-operative day one, rats received daily intraperitoneal injections of MPH (5mg/kg) or saline. Beam balance (BB) and beam walking (BW) were assessed on postoperative days 1-5. Exploratory behavior was assessed using an open field free choice novelty (FCN) task on day 13. Spatial memory was assessed with a Morris water maze (MWM) task on days 14-20. Multivariate analyses showed TBI females performed better than TBI males on both motor tasks (P<0.05 both comparisons), and MPH improved BB performance for both male and female injury groups (P=0.05) compared to their respective vehicle treated injury groups. Multivariate analysis showed that MPH enhanced MWM performance (spatial learning and retention) after TBI. Significant improvements were noted in injured males treated with MPH compared to their vehicle control (P<0.05) with respect to improvements in memory acquisition and retention. Further, injured females treated with MPH had faster swimming speeds than all other groups (P<0.05 all comparisons), and MPH increased activity in TBI females but not males in the FCN task (P<0.05). These results suggest that MPH is beneficial after TBI. However there are gender specific drug differences in behavioral performance and sensitivity to treatment with MPH that may have implications for treatment efficacy and dosing clinically after TBI.

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Rapid Effects of Estrogen or Progesterone on the Amphetamine-Induced Increase in Striatal Dopamine Are Enhanced by Estrogen Priming

Cited by 177 publications

References 43 publications

Acquisition of cocaine self-administration in ovariectomized female rats: Effect of estradiol dose or chronic estradiol administration

Acquisition of cocaine self-administration in ovariectomized female rats: Effect of estradiol dose or chronic estradiol administration

Sex Differences and Hormonal Influences on Acquisition of Cocaine Self-Administration in Rats

Gender associations with chronic methylphenidate treatment and behavioral performance following experimental traumatic brain injury

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