Rapid Clearance of Rh Positive Blood During Experimental Rh Immunisation

Woodrow, J. C.; Finn, Ronald D.; Krevans, Julius R.

doi:10.1111/j.1423-0410.1969.tb00407.x

Cited by 24 publications

(13 citation statements)

References 18 publications

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“…The observations of Woodrow et al (1969), supported by those reported here, strongly suggest the existence of two kinds of Rh negative subject, one who is capable of becoming immunized to the Rh antigen and does so after a single stimulus, and one who cannot become immunized to Rh, even after repeated stimuli. Of course, the difference may not be absolute and it may be that one kind becomes immunized much more easily than the other.…”

Section: Discussionsupporting

confidence: 83%

“…The results of Woodrow et al(1969), of which a preliminary report was given by Krevans et aE (1964, were essentially similar: 11 Rh negative subjects were given 3-11 injections of 5 ml (occasionally 10 ml) of Rh-positive blood at intervals usually of 6 weeks but occasionally as long as 7 mth. Four out of 11 of the subjects failed to develop anti-Rh(D) and in these the Cr survival of Rh positive red cells was normal on three to five occasions.…”

Section: Discussionmentioning

confidence: 78%

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Differences between Rh(D) Negative Subjects in Response to Rh(D) Antigen

1970

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Summary Further evidence is produced of the existence of two kinds of Rh negative subject: the first forms anti‐Rh after a single injection although sometimes in such a low concentration that a clearance study with a small dose of Rh positive red cells is required to detect it; antibody usually becomes detectable serologically after a second, spaced injection; the second kind of Rh negative subject fails to form anti‐Rh even after several injections and has a repeatedly normal survival of Rh positive red cells and may be incapable of becoming immunized to the Rh antigen. In the present series of 34 Rh negative subjects, approximately 50% became immunized following injections of Rh positive red cells; the number is not significantly different from the incidence of approximately 60% reported in other published series. Some further evidence is provided that the rate of clearance of Rh positive red cells is more sensitive than any serological test in indicating the presence of a low concentration of anti‐Rh and that different examples of anti‐Rh in presumably similar concentrations in the plasma produce very different rates of red cell clearance. Of seven subjects given at least two injections of D positive Bua‐positive red cells, four formed anti‐D, but only one formed anti‐Bua.

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Section: Discussionsupporting

confidence: 83%

Section: Discussionmentioning

confidence: 78%

Differences between Rh(D) Negative Subjects in Response to Rh(D) Antigen

1970

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“…3 and 6 -would seem to have similar antibody response to those described by Gunson et al [3] and by Mollison et al [5], who had volunteers with anti bodies which decreased in titre or disappeared after repeated stimuli. This would appear to be similar to the type of response reported by Woodrow et al [6], where the survival time of Rh (D)-positive cells injected into Rh (D)-negative volunteers increased, despite second and third injections which lead eventually to detectable antibody formation: It may represent a change from the production of IgM to IgG anti-D.…”

Section: Discussionsupporting

confidence: 65%

The Production of High Titre Rh (D) Antibody in Male Volunteers

Gibson¹

1973

Vox Sanguinis

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13 male volunteers, all group A Rh-negative, were immunised with fresh A Rh-positive washed red cells. All 13 produced anti-D. The antibody produced was to be used in the prevention of Rh haemolytic disease. In 8 of the 13 donors, the antibody was of a sufficiently high albumin titre (128 or more) to be used as intended. By plasmapheresis, these eight volunteers have so far donated 149 units of plasma. The first volunteers started the course of injections in March 1970. The first antibody of sufficiently high titre to make plasmapheresis worthwhile was obtained in February 1971. The shortest interval from first injection to first donation was 39 weeks.

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“…Although IgM development during a primary exposure to antigen can actually shorten the lifespan of transfused blood [101, 102], primary antibody responses do not typically result in a routinely detectable HTR. However, during this primary antigen exposure, T cell-mediated class switching results in significant production of IgG.…”

Section: Factors Influencing Complement Activationmentioning

confidence: 99%

Initiation and Regulation of Complement during Hemolytic Transfusion Reactions

Stowell

Winkler

Maier

et al. 2012

Clinical and Developmental Immunology

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Hemolytic transfusion reactions represent one of the most common causes of transfusion-related mortality. Although many factors influence hemolytic transfusion reactions, complement activation represents one of the most common features associated with fatality. In this paper we will focus on the role of complement in initiating and regulating hemolytic transfusion reactions and will discuss potential strategies aimed at mitigating or favorably modulating complement during incompatible red blood cell transfusions.

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Rapid Clearance of Rh Positive Blood During Experimental Rh Immunisation

Cited by 24 publications

References 18 publications

Differences between Rh(D) Negative Subjects in Response to Rh(D) Antigen

Differences between Rh(D) Negative Subjects in Response to Rh(D) Antigen

The Production of High Titre Rh (D) Antibody in Male Volunteers

Initiation and Regulation of Complement during Hemolytic Transfusion Reactions

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