Rapid Brain Scanning with Technetium-99m

Harper, Paul V.; Fink, R.; Charleston, D.B.; Beck, R.N.; Lathrop, K.A.; Evans, Joseph P.

doi:10.1177/02841851660050p224

Cited by 11 publications

(11 citation statements)

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“…7 This technology revolutionized radiopharmaceutical chemistry research, and small 99m Tc-based radiopharmaceutical research was accelerated to a greater extent.…”

Section: Radiometals For Spectmentioning

confidence: 99%

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Metallic radionuclides in the development of diagnostic and therapeutic radiopharmaceuticals

2011

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Metallic radionuclides are the mainstay of both diagnostic and therapeutic radiopharmaceuticals. Therapeutic nuclear medicine is less advanced but has tremendous potential if the radionuclide is accurately targeted. Great interest exists in the field of inorganic chemistry for developing target specific radiopharmaceuticals based on radiometals for non-invasive disease detection and cancer radiotherapy. This perspective will focus on the nuclear properties of a few important radiometals and their recent applications to developing radiopharmaceuticals for imaging and therapy. Other topics for discussion will include imaging techniques, radiotherapy, analytical techniques, and radiation safety. The ultimate goal of this perspective is to introduce inorganic chemists to the field of nuclear medicine and radiopharmaceutical development, where many applications of fundamental inorganic chemistry can be found.

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“…7 This technology revolutionized radiopharmaceutical chemistry research, and small 99m Tc-based radiopharmaceutical research was accelerated to a greater extent.…”

Section: Radiometals For Spectmentioning

confidence: 99%

“…Extensive research on the coordination chemistry of 99m Tc led to the successful development of several first-generation 99m Tc-based radiotracers, 6 c ,7 which are known as ‘technetium essential agents’ (Fig. 5).…”

Section: Radiometals For Spectmentioning

confidence: 99%

Metallic radionuclides in the development of diagnostic and therapeutic radiopharmaceuticals

2011

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“…A considerable number of authors have already reported on their achievements in technetium brain scanning [3,11,16 [18] found no difference worth mentioning between the reliability of 09mTc and that of 197Hg, nor between the results obtained with a moving scanner and those obtained with a gamma camera either. When A bassioun el al.…”

Section: Scanning the Brain With Various Radioisotopesmentioning

confidence: 99%

Scanning the Brain with Various Radioisotopes

Eck¹,

Woldring²

1969

Europ Neurol

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“…It is not known whether this results from secretion in the gastric juices or swallowed saliva, for the concentration in saliva reached 46% per litre at 3 hours and *thereafter dropped sharply. Uptake of Tc99m in the parotid and submaxilliary glands has been demonstrated by Harper, Beck, Charleston and Lathrop (1964) in their thyroid scans. No other significant concentration has been observed.…”

Section: Metabolismmentioning

confidence: 99%