Daniel C. Williams, Rachid El Bejjani, Paula Mugno Ramirez, Sean Coakley, Shin Ae Kim, Hyewon Lee, Quan Wen, Aravi Samuel, Hang Lu, Massimo A. Hilliard, Marc Hammarlund
Inactivation of selected neurons in vivo can define their contribution to specific developmental outcomes, circuit functions, and behaviors. Here, we show that the optogenetic tool KillerRed selectively, rapidly, and permanently inactivates different classes of neurons in C. elegans in response to a single light stimulus, through generation of reactive oxygen species (ROS). Ablation scales from individual neurons in single animals to multiple neurons in populations, and can be applied to freely behavi…
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