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Cited by 3 publications
(2 citation statements)
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References 8 publications
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“…Gaur et al. (2016) found that rapamycin inhibited mTOR by forming a complex with FKBP12, thereby regulating the increased mRNA expression levels of autophagy genes atg1 , atg5 , and atg8b in intestinal tissues to improve intestinal aging and antioxidant capacity in D. melanogaster (Gaur et al., 2016). Atg5 is necessary for the formation of autophagosomes and is the specific and essential substance of autophagy.…”
Section: Discussionmentioning
confidence: 99%
“…Gaur et al. (2016) found that rapamycin inhibited mTOR by forming a complex with FKBP12, thereby regulating the increased mRNA expression levels of autophagy genes atg1 , atg5 , and atg8b in intestinal tissues to improve intestinal aging and antioxidant capacity in D. melanogaster (Gaur et al., 2016). Atg5 is necessary for the formation of autophagosomes and is the specific and essential substance of autophagy.…”
Section: Discussionmentioning
confidence: 99%
“…DR and treatment with DR mimetics such as rapamycin, 2,5-dimethyl-celecoxib (DMC), and metformin have been shown to promote gut epithelial homeostasis with aging [12,36,37,43]. In addition, consistent with DR mimetic pharmacological antiaging regimens, our recent work also shows that DR significantly reduces age-related intestinal flora growth rate (unpublished data).…”
Section: Gut Function During Dr-induced Longevitymentioning
confidence: 61%