Qian-Li Xue, Huanle Yang, Hui-Fen Li, Peter M. Abadir, Tyesha N. Burks, Lauren G. Koch, Steven L. Britton, Joshua Carlson, Laura Chen, Jeremy D. Walston, Sean X. Leng
Abstract:Rapamycin is known to extend lifespan. We conducted a randomized placebo-controlled study of enteric rapamycin-treatment to evaluate its effect on physical function in old low capacity runner (LCR) rats, a rat model selected from diverse genetic background for low intrinsic aerobic exercise capacity without genomic manipulation and characterized by increased complex disease risks and aging phenotypes. The study was performed in 12 male and 16 female LCR rats aged 16-22 months at baseline. The treatment group w…
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