Search citation statements

Order By: Relevance

Paper Sections

Select...
2
1
1
1

Citation Types

0
9
0

Year Published

2018
2018
2020
2020

Publication Types

Select...
5

Relationship

0
5

Authors

Journals

citations
Cited by 14 publications
(9 citation statements)
references
References 7 publications
(9 reference statements)
0
9
0
Order By: Relevance
“…Rapamycin, (International Nonproprietary Name: sirolimus), is an inhibitor of mTOR, which results in an extended life span and prevents age-related diseases [157][158][159][160] by mediating SIRT1 expression [161,162]. mTOR is a serine-threonine kinase that plays a role in modulating cell survival, growth, proliferation, motility, protein synthesis and transcription [163] and inducing autophagy [164][165][166].…”
Section: Rapamycinmentioning
confidence: 99%
“…Rapamycin, (International Nonproprietary Name: sirolimus), is an inhibitor of mTOR, which results in an extended life span and prevents age-related diseases [157][158][159][160] by mediating SIRT1 expression [161,162]. mTOR is a serine-threonine kinase that plays a role in modulating cell survival, growth, proliferation, motility, protein synthesis and transcription [163] and inducing autophagy [164][165][166].…”
Section: Rapamycinmentioning
confidence: 99%
“…In two dozen studies using different strains of mice, rapamycin extended life span. Starting from a thorough study by Harrison et al [155] and followed by nearly simultaneous studies by others [33,108], the anti-aging effects of rapamycin have been confirmed many times (see for references: [113,150,156,157]). Importantly, rapamycin and everolimus are indicated in most, if not all, age-related diseases, from cancer to neurodegeneration [2,158].…”
Section: Rapamycin Is a Proven Anti-aging Drugmentioning
confidence: 99%
“…In both rats and mice, rapamycin (sirolimus) prevents diabetic nephropathy [65][66][67][68][69][70][71][72][73][74][75][76][77]. In numerous independent studies, rapamycin was found to prolong life in a variety of mouse strains (see for references [78][79][80][81]). Rapamycin also improved metabolic functioning in non-human primates [82], and no symptoms of pseudo-diabetes were observed in relatively healthy elderly and healthy volunteers [83][84][85][86][87].…”
Section: Rapamycin-induced Pseudo-diabetesmentioning
confidence: 99%