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citations
Cited by 25 publications
(11 citation statements)
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References 8 publications
(15 reference statements)
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“…In our study, the older subjects (average age 74.5 years) remain healthy into old age, suggesting that the TLR1-mediated reduction in PMN function reported here, one of multiple deficiencies noted in immunosenescence [1], may be relevant to surviving other health complications, such as cancer or autoimmune diseases. Recent theories of aging and evidence that caloric restriction enhances longevity suggest paradoxically that reduction in anabolic processes may be beneficial to survival [38]. Caloric restriction is mediated in part by the TOR (target of rapamycin) pathway -- itself under the control of the circadian clock [39]— and while rapamycin inhibition of TOR signaling may be beneficial for longevity, during acute infection it can lead to inappropriate immune responses and increased tissue destruction [40].…”
Section: Discussionmentioning
confidence: 99%
“…In our study, the older subjects (average age 74.5 years) remain healthy into old age, suggesting that the TLR1-mediated reduction in PMN function reported here, one of multiple deficiencies noted in immunosenescence [1], may be relevant to surviving other health complications, such as cancer or autoimmune diseases. Recent theories of aging and evidence that caloric restriction enhances longevity suggest paradoxically that reduction in anabolic processes may be beneficial to survival [38]. Caloric restriction is mediated in part by the TOR (target of rapamycin) pathway -- itself under the control of the circadian clock [39]— and while rapamycin inhibition of TOR signaling may be beneficial for longevity, during acute infection it can lead to inappropriate immune responses and increased tissue destruction [40].…”
Section: Discussionmentioning
confidence: 99%
“…[41-43]The mechanism of acquired resistance to rapamycin analogs remains unknown at this time. There is increasing recognition that tumors evolve with progression and with treatment pressure.…”
Section: Discussionmentioning
confidence: 99%
“…Inhibitors of mTOR can suppress geroconversion, protecting adult stem cells from undergoing premature cell senescence while simultaneously preventing their oncogenic transformation [35]. Amongst mTOR inhibitors, Rapamycin has been defined as a “longevity enhancer and cancer preventative agent” in the context of p53 deficiency [36]. Indeed, continuous treatment with Rapamycin or a novel Rapamycin formulation (Rapatar) delayed carcinogenesis in tumor-prone p53 + / − and p53 − / − mice respectively, most likely by slowing down the process of aging [37, 38].…”
Section: Introductionmentioning
confidence: 99%