Randomized trial of topical periocular castor oil treatment for blepharitis

Müntz, Alex; Sandford, Emma C; Claassen, Marna; Curd, Lauren; Jackson, Alice K.; Watters, Grant; Wang, Michael T.M.; Craig, Jennifer P.

doi:10.1016/j.jtos.2020.05.007

Cited by 16 publications

(22 citation statements)

References 31 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The presence of collarettes is considered a pathognomonic sign of Demodex blepharitis; therefore, it may be clinically valuable to monitor the improvement in collarettes after any treatment [4]. However, there is paucity of studies that have measured collarettes or cylindrical dandruff as a study outcome in patients with Demodex blepharitis [3,34,37]. The present study is the first randomized vehicle-controlled trial to study change in collarette grade in eyes with Demodex blepharitis.…”

Section: Discussionmentioning

confidence: 94%

Safety and efficacy of lotilaner ophthalmic solution, 0.25% for the treatment of blepharitis due to demodex infestation: A randomized, controlled, double-masked clinical trial

González-Salinas

Karpecki²,

Yeu

et al. 2022

Contact Lens and Anterior Eye

View full text Add to dashboard Cite

To evaluate the safety and efficacy of lotilaner ophthalmic solution, 0.25% for the treatment of blepharitis due to Demodex infestation compared to vehicle control. Methods: In this phase II, randomized, controlled, double-masked clinical trial, 60 eligible participants with Demodex blepharitis were randomly assigned in a 1:1 ratio to receive either topical lotilaner ophthalmic solution, 0.25% (Tarsus Pharmaceuticals, Inc., Irvine, CA) (study group) or the vehicle without lotilaner (control group) bilaterally twice a day for 28 days. Participants were followed at Days 7, 14, 28, 60 and 90. The efficacy parameters were change in collarette grade and Demodex density at Day 28. Safety parameters were adverse events, changes in corrected distance visual acuity (CDVA), intraocular pressure (IOP) and slit-lamp biomicroscopy.Results: The study group showed a statistically significant decrease in collarette grade compared to the control group beginning at Day 14 (p = 0.003) in the upper eyelid and at Day 28 (p = 0.003) in the lower eyelid. Decreases in both lids were maintained through Day 90 (p < 0.001). At Day 28, mite eradication was achieved in 66.7% and 25.9% of eyes in the study and control group (p = 0.005); at Day 90, these proportions were 68.2% and 18.5% (p = 0.001), respectively. No serious adverse events or clinically significant changes in CDVA and IOP were observed. Conclusion: For Demodex blepharitis, treatment with lotilaner ophthalmic solution, 0.25% for 4 weeks is safe and effective. The improvement in collarette grade and mite density observed during the treatment period persisted for at least two months following treatment cessation.

show abstract

Section: Discussionmentioning

confidence: 94%

Safety and efficacy of lotilaner ophthalmic solution, 0.25% for the treatment of blepharitis due to demodex infestation: A randomized, controlled, double-masked clinical trial

González-Salinas

Karpecki²,

Yeu

et al. 2022

Contact Lens and Anterior Eye

View full text Add to dashboard Cite

show abstract

“…Castor oil is a natural derivative of the Ricinus communis plant that possesses anti-inflammatory, anti-nociceptive, antioxidant, and antimicrobial properties [43,[46][47][48]. Castor oil eye drops have been administered safely in several eye disorders like mild dry eye, blepharitis, contact lens discomfort, refractory Meibomian gland dysfunction [49][50][51].…”

Section: Discussionmentioning

confidence: 99%

Formulation and Stability of Ataluren Eye Drop Oily Solution for Aniridia

et al. 2020

View full text Add to dashboard Cite

Congenital aniridia is a rare and severe panocular disease characterized by a complete or partial iris defect clinically detectable at birth. The most common form of aniridia occurring in around 90% of cases is caused by PAX6 haploinsufficiency. The phenotype includes ptosis, nystagmus, corneal limbal insufficiency, glaucoma, cataract, optic nerve, and foveal hypoplasia. Ataluren eye drops aim to restore ocular surface PAX6 haploinsufficiency in aniridia-related keratopathy (ARK). However, there are currently no available forms of the ophthalmic solution. The objective of this study was to assess the physicochemical and microbiological stability of ataluren 1% eye drop in preservative-free low-density polyethylene (LDPE) bottle with an innovative insert that maintains sterility after opening. Because ataluren is a strongly lipophilic compound, the formulation is complex and involves a strategy based on co-solvents in an aqueous phase or an oily formulation capable of totally dissolving the active ingredient. The visual aspect, ataluren quantification by a stability-indicating chromatographic method, and microbiological sterility were analyzed. The oily formulation in castor oil and DMSO (10%) better protects ataluren hydrolysis and oxidative degradation and permits its complete solubilization. Throughout the 60 days period, the oily solution in the LDPE bottle remained clear without any precipitation or color modification, and no drug loss and no microbial development were detected. The demonstrated physical and microbiological stability of ataluren 1% eye drop formulation at 22–25 °C might facilitate clinical research in aniridia.

show abstract

“…31 The potential for castor oil to stimulate hair growth may directly target sequelae such as madarosis. 103…”

Section: Hair Growthmentioning

confidence: 99%

Therapeutic potential of castor oil in managing blepharitis, meibomian gland dysfunction and dry eye

Sandford

Müntz

Craig

2021

Clinical and Experimental Optometry

Self Cite

View full text Add to dashboard Cite

The multifactorial pathogenesis and interrelationship of blepharitis, meibomian gland dysfunction and dry eye disease poses challenges to any therapeutic approach. Current treatments are mostly palliative, with success limited by perceived inefficacy and poor patient compliance. Castor oil, a natural derivative of the Ricinus communis plant, is widely used as an emollient in cosmetics and personal care products, drug delivery systems and wound dressings. Castor oil is deemed safe and tolerable, with strong anti-microbial, anti-inflammatory, anti-nociceptive, analgesic, antioxidant, wound healing and vaso-constrictive properties. Its main constituent, ricinoleic acid, has a bipolar molecular structure that promotes the formation of esters, amides and polymers. These can supplement deficient physiological tear film lipids, enabling enhanced lipid spreading characteristics and reducing aqueous tear evaporation. Studies reveal that castor oil applied topically to the ocular surface has a prolonged residence time, facilitating increased tear film lipid layer thickness, stability, improved ocular surface staining and symptoms. This review summarises the properties, current uses of, and therapeutic potential of castor oil in managing ocular surface disease. The biochemical, medicinal actions of castor oil are explored from the perspective of ocular surface pathology, and include microbial and demodectic over-colonisation, inflammatory and oxidative processes, as well as clinical signs and symptoms of dryness and discomfort.

show abstract

Randomized trial of topical periocular castor oil treatment for blepharitis

Cited by 16 publications

References 31 publications

Safety and efficacy of lotilaner ophthalmic solution, 0.25% for the treatment of blepharitis due to demodex infestation: A randomized, controlled, double-masked clinical trial

Safety and efficacy of lotilaner ophthalmic solution, 0.25% for the treatment of blepharitis due to demodex infestation: A randomized, controlled, double-masked clinical trial

Formulation and Stability of Ataluren Eye Drop Oily Solution for Aniridia

Therapeutic potential of castor oil in managing blepharitis, meibomian gland dysfunction and dry eye

Contact Info

Product

Resources

About