Randomized trial of salbutamol via metered-dose inhaler with spacer versus nebulizer for acute wheezing in children less than 2 years of age

Cost‐effectiveness analysis of phenotypic‐guided versus guidelines‐guided bronchodilator therapy in viral bronchiolitis

“…However, this parameter uncertainty was handled using several accepted methods to deal with uncertainly in cost‐effectiveness models, such as the Delphi technique and deterministic and probabilistic sensitivity analyses, 44–46 our base‐case results being robust to variations in values of this probability. In addition, this probability value was virtually identical to that reported in an RCT when the analysis was restricted to first‐time wheezing children 19 . Second, cost data were obtained from a single clinical center and may not be representative of the whole country.…”

Salbutamol via Metered-Dose Inhaler With Spacer Versus Nebulization for Acute Treatment of Pediatric Asthma in the Emergency Department

“…Similar findings have been reported by others. 13,17,19 In our study, about 15% of asthma children attended at the emergency department during the study periods were not treated, nearly 50% received a single dose of bronchodilators, and in more than 60% the use of combined systemic steroids was not considered necessary. Overall, almost 70% of asthma-related consultations can be considered mild episodes and susceptible to be managed in the outpatient setting.…”

Survey of Albuterol Delivery Methods in Emergency Departments for Acute Asthma Exacerbation in Children 2 Months to 15 Years

“…Literature of the past two decades demonstrated that the MDI with VHC is just as effective for asthmatic infants and children with an acute asthma exacerbation. [11][12][13][14] Cochrane systematic reviews and a meta-analysis of the literature are supportive of these findings. 5,15,16 Recent evidence-based guidelines on aerosol therapy device selection reported that the nebulizer and MDI with VHC were equally appropriate for the delivery of short-acting ␤-2-agonists in the ED.…”