Randomized study on early detection of lung cancer with MSCT in Germany: study design and results of the first screening round

Becker, Nikolaus; Motsch, Erna; Groß, Marie-Luise; Eigentopf, A.; Heußel, Claus-Peter; Dienemann, Hendrik; Schnabel, Philipp A.; Pilz, Lothar R.; Eichinger, Monika; Optazaite, D.-E.; Puderbach, Michael; Tremper, Jan; Delorme, Stefan

doi:10.1007/s00432-012-1228-9

Cited by 167 publications

(115 citation statements)

References 15 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Examples would be non-contrast cardiac CTs in the Heinz-Nixdorf Recall Study, the Rotterdam Study, the AGESReykjavik Study or the Swedish CardioPulmonary BioImage Study for quantifying coronary calcification [22,27,34,35]. Another example would be the use of low-dose CT for lung cancer screening [36,37]. The use of x-rays must always be assessed in relation to the scientific and social benefits, and the implicit risk must be justified.…”

Section: Analysis Of Image-based Features In Association With Clinicamentioning

confidence: 99%

Population-Based Imaging and Radiomics: Rationale and Perspective of the German National Cohort MRI Study

Schlett

Hendel

Weckbach

et al. 2016

Fortschr Röntgenstr

View full text Add to dashboard Cite

The MRI study within the German National Cohort, a large-scale, population-based, longitudinal study in Germany, comprises comprehensive characterization and phenotyping of?a?total of 30?000 participants using 3-Tesla?whole-body MR imaging. A multi-centric study design was established together with dedicated core facilities for e.?g. managing incidental findings or providing quality assurance. As such, the study represents a unique opportunity to substantially impact imaging-based risk stratification leading to personalized and precision medicine. Supported by the developments in the field of computational science, the newly developing scientific field of radiomics has large potential for the future. In the present article we provide an overview on population-based imaging and Radiomics and conceptualize the rationale and design of the MRI study within the German National Cohort. Key Points: ??Population-based imaging and Radiomics constitute two emerging fields with great oppertunities and challenges for Radiology. ??As part of the MRI-study of the NAKO approximately 30 000 subjects will undergo 3 Tesla whole-body MRI. ??MR Imaging data is publicly accessable and will provide important insights into the natural history of disease processes and personalized risk profiles of the general population. Citation Format: ??Schlett CL, Hendel T, Weckbach S et?al. Population-Based Imaging and Radiomics: Rationale and Perspective of the German National Cohort MRI Study. Fortschr R?ntgenstr 2016; 188: 652???661

show abstract

Section: Analysis Of Image-based Features In Association With Clinicamentioning

confidence: 99%

Population-Based Imaging and Radiomics: Rationale and Perspective of the German National Cohort MRI Study

Schlett

Hendel

Weckbach

et al. 2016

Fortschr Röntgenstr

View full text Add to dashboard Cite

show abstract

“…Three studies did not demonstrate a benefit of lung cancer screening with CT in terms of mortality, but these were insufficiently powered to reliably draw such conclusion [10][11][12] . There are a further five ongoing studies that are yet to report on the final results, but some will be able to give answers to the question whether CT screening improves outcome of lung cancer patients [13][14][15][16][17] . The Nederlands-Leuvens Longkanker Screening Onderzoek (NELSON) study is a Dutch/Belgian project, which recruited 20000 high-risk subjects and randomised half of them for low-dose CT and the other half for CXR screening [13] .…”

Section: Ctmentioning

confidence: 99%

Lung cancer screening: Computed tomography or chest radiographs?

Beek

Mirsadraee

Murchison

2015

WJR

View full text Add to dashboard Cite

Worldwide, lung cancer is the leading cause of mortality due to malignancy. The vast majority of cases of lung cancer are smoking related and the most effective way of reducing lung cancer incidence and mortality is by smoking cessation. In the Western world, smoking cessation policies have met with limited success. The other major means of reducing lung cancer deaths is to diagnose cases at an earlier more treatable stage employing screening programmes using chest radiographs or low dose computed tomography. In many countries smoking is still on the increase, and the sheer scale of the problem limits the affordability of such screening programmes. This short review article will evaluate the current evidence and potential areas of research which may benefit policy making across the world.

show abstract

“…Table 1 provides a list of select RCTs and highlights the differences in their respective inclusion criteria, screening intervals and definitions for positive screen results. [25][26][27][28][29][30][31] Since the ultimate objective of screening is to identify and treat early-stage LC, the participants' fitness for lung surgery is an important factor to consider when assessing eligibility for screening. [12] Accordingly, it is noteworthy that all the trials listed excluded those individuals with comorbidities that precluded them from curative LC surgery.…”

Section: Screening With Ldctmentioning

confidence: 99%

“…NLST [16] DANTE [26] DLCST [27] LUSI [28] ITALUNG [29] MILD [30] NELSON [ Table 2. Professional Societies' Guidelines for LC Screening [25] Society (Reference) Recommendation Grade NCCN [19] Annual LDCT in high-risk individuals Group 1: age 55 -79 y with >30 pack-years, current or former smokers who quit within the past 15 y Group 2: age >50 y with >20 pack-years and 1 additional risk factor * B USPSTF [12] Annual LDCT in high-risk individuals: age 55 -80 y with >30 pack-years, current or former smokers who have quit within the past 15 y † B ACCP/ASCO [17] Annual LDCT in high-risk individuals: age 55 -74 y with >30 pack-years, current or former smokers who quit within the past 15 y, but only in settings that can provide multidisciplinary care similar to that provided in the NLST 2B ACS [32] Annual LDCT in high-risk individuals: age 55 -74 y with >30 pack-years, current or former smokers who quit within the past 15 y, who are in good health B AATS [33] Annual Overdiagnosis refers to the detection of a cancer that would not otherwise have become clinically relevant during the patient's lifetime.…”

Section: Reviewmentioning

confidence: 99%

Lung Cancer Screening

Schar¹

2015

S Afr Res J

View full text Add to dashboard Cite

Lung cancer (LC) is the leading cause of cancer-related death worldwide. Its overall poor prognosis is attributable to the fact that most patients remain asymptomatic until the disease is advanced and, therefore, present with late-stage incurable disease. e rationale for LC screening is that early detection of asymptomatic disease oers the opportunity for earlier intervention, at a stage when denitive cure is still feasible, which has the potential to reduce LC-related mortality and morbidity. e ndings of the National Lung Screening Trial provided the rst strong evidence in support of this rationale. Since its publication, several professional organisations and societies have developed guidelines recommending the implementation of LC screening with low-dose computed tomography in asymptomatic, high-risk individuals. Although the benets of such screening programmes may be signicant, they must be carefully weighed against the potential harms to the relatively large number of healthy individuals who would undergo screening. is review examines the available evidence and current recommendations for LC screening, including benets, potentials harms and requirements for implementation of a high-quality, safe and eective programme. In addition, the costs and availability of LC screening programmes in both the global and local settings are considered.

show abstract

Randomized study on early detection of lung cancer with MSCT in Germany: study design and results of the first screening round

Cited by 167 publications

References 15 publications

Population-Based Imaging and Radiomics: Rationale and Perspective of the German National Cohort MRI Study

Population-Based Imaging and Radiomics: Rationale and Perspective of the German National Cohort MRI Study

Lung cancer screening: Computed tomography or chest radiographs?

Lung Cancer Screening

Contact Info

Product

Resources

About