Randomized study of chlorambucil (CB) compared to interferon (alfa-2b) combined with CB in low-grade non-Hodgkin's lymphoma: An interim report of a randomized study

A randomized controlled trial to evaluate the role of interferon as initial and maintenance therapy in patients with follicular lymphoma

“…The explanation for this may be the greater degree of haematological toxicity incurred with the combination, which in turn resulted in delays in administering Chlorambucil. Neither of the 2 other published studies in which IFN has been combined with an alkylating agent has in fact shown any advantage for the combination (Chisesi et al, 1991;Peterson et al, 1997). In contrast, the study reported by the 'GELF' Group (Solal-Celigny et al, 1993), did show a significantly higher response rate for IFN given with a more intensive, Adriamycin-containing regimen.…”

A randomized controlled trial to evaluate the role of interferon as initial and maintenance therapy in patients with follicular lymphoma

“…The explanation for this may be the greater degree of haematological toxicity incurred with the combination, which in turn resulted in delays in administering Chlorambucil. Neither of the 2 other published studies in which IFN has been combined with an alkylating agent has in fact shown any advantage for the combination (Chisesi et al, 1991;Peterson et al, 1997). In contrast, the study reported by the 'GELF' Group (Solal-Celigny et al, 1993), did show a significantly higher response rate for IFN given with a more intensive, Adriamycin-containing regimen.…”

Cancer Immunotherapy

“…In the pre-rituximab era, five randomized trials in indolent B-cell lymphoma, from five different countries, established that the addition of IFN-α to induction chemotherapy that did not include an anthracycline had no significant impact on RR or survival, but maintenance IFN-α was associated with a modest increased TTP in most of the trials. 197 –201 Two multicenter randomized trials showed that the addition of IFN-α enhanced RR, PFS, and OS when combined with chemotherapy that included doxorubicin in the treatment of more aggressive lymphomas. 202 –205 However, a third trial failed to confirm any benefit from this approach.…”

High Response Rates and Lasting Remissions After Low-Dose Involved Field Radiotherapy in Indolent Lymphomas

“…The interval between subsequent relapses tends to shorten over time. [2][3][4][5][6][7][8] There is no consensus as to which first-line treatment should be provided to patients with advanced stage FL, although in general, either cyclophosphamide, vincristine, prednisone (CVP) polychemotherapy or chlorambucil single-agent therapy [9][10][11][12][13][14][15][16][17][18][19][20][21][22] are advised. These regimens are applied in recurrent disease as well.…”

A randomized controlled trial to evaluate the role of interferon as initial and maintenance therapy in patients with follicular lymphoma

“…The explanation for this may be the greater degree of haematological toxicity incurred with the combination, which in turn resulted in delays in administering Chlorambucil. Neither of the 2 other published studies in which IFN has been combined with an alkylating agent has in fact shown any advantage for the combination (Chisesi et al, 1991;Peterson et al, 1997). In contrast, the study reported by the 'GELF' Group (Solal-Celigny et al, 1993), did show a significantly higher response rate for IFN given with a more intensive, Adriamycin-containing regimen.…”

Cancer Immunotherapy

“…In the pre-rituximab era, five randomized trials in indolent B-cell lymphoma, from five different countries, established that the addition of IFN-α to induction chemotherapy that did not include an anthracycline had no significant impact on RR or survival, but maintenance IFN-α was associated with a modest increased TTP in most of the trials. 197 –201 Two multicenter randomized trials showed that the addition of IFN-α enhanced RR, PFS, and OS when combined with chemotherapy that included doxorubicin in the treatment of more aggressive lymphomas. 202 –205 However, a third trial failed to confirm any benefit from this approach.…”

High Response Rates and Lasting Remissions After Low-Dose Involved Field Radiotherapy in Indolent Lymphomas

“…The interval between subsequent relapses tends to shorten over time. [2][3][4][5][6][7][8] There is no consensus as to which first-line treatment should be provided to patients with advanced stage FL, although in general, either cyclophosphamide, vincristine, prednisone (CVP) polychemotherapy or chlorambucil single-agent therapy [9][10][11][12][13][14][15][16][17][18][19][20][21][22] are advised. These regimens are applied in recurrent disease as well.…”

A randomized controlled trial to evaluate the role of interferon as initial and maintenance therapy in patients with follicular lymphoma

“…The explanation for this may be the greater degree of haematological toxicity incurred with the combination, which in turn resulted in delays in administering Chlorambucil. Neither of the 2 other published studies in which IFN has been combined with an alkylating agent has in fact shown any advantage for the combination (Chisesi et al, 1991;Peterson et al, 1997). In contrast, the study reported by the 'GELF' Group (Solal-Celigny et al, 1993), did show a significantly higher response rate for IFN given with a more intensive, Adriamycin-containing regimen.…”

Cancer Immunotherapy

“…In the pre-rituximab era, five randomized trials in indolent B-cell lymphoma, from five different countries, established that the addition of IFN-α to induction chemotherapy that did not include an anthracycline had no significant impact on RR or survival, but maintenance IFN-α was associated with a modest increased TTP in most of the trials. 197 –201 Two multicenter randomized trials showed that the addition of IFN-α enhanced RR, PFS, and OS when combined with chemotherapy that included doxorubicin in the treatment of more aggressive lymphomas. 202 –205 However, a third trial failed to confirm any benefit from this approach.…”

High Response Rates and Lasting Remissions After Low-Dose Involved Field Radiotherapy in Indolent Lymphomas

“…The interval between subsequent relapses tends to shorten over time. [2][3][4][5][6][7][8] There is no consensus as to which first-line treatment should be provided to patients with advanced stage FL, although in general, either cyclophosphamide, vincristine, prednisone (CVP) polychemotherapy or chlorambucil single-agent therapy [9][10][11][12][13][14][15][16][17][18][19][20][21][22] are advised. These regimens are applied in recurrent disease as well.…”