Randomized placebo‐controlled trial assessing the effect of bifidobacteria‐fermented milk on active ulcerative colitis

Abstract

SUMMARYBackground: Probiotics are efficacious for treating and maintaining remission of ulcerative colitis. Aim: To conduct a randomized placebo-controlled trial of bifidobacteria-fermented milk supplementation as a dietary adjunct in treating active ulcerative colitis. Methods: Twenty patients with mild to moderate, active, ulcerative colitis randomly received 100 mL/day of bifidobacteria-fermented milk or placebo for 12 weeks with conventional treatment. Results: Clinical and endoscopic activity indices and histological scores were similar in the two groups before treatment. Although improvements were significant in both groups, the clinical activity index was significantly

Anti-inflammatory activity of probiotic Bifidobacterium: Enhancement of IL-10 production in peripheral blood mononuclear cells from ulcerative colitis patients and inhibition of IL-8 secretion in HT-29 cells

“…The efficacy of bifidobacteria-fermented milk (BFM) in the treatment of ulcerative colitis has been reported elsewhere [7,8] . To determine the anti-inflammatory activity of probiotic Bifidobacterium strains in the BFM, we firstly investigated the effects of these strains on the production of anti-inflammatory cytokine IL-10 by PBMNC isolated from UC patients in vitro.…”

“…There is evidence that probiotic treatment is effective against UC [3][4][5][6] . We have previously shown that treatment with bifidobacteriafermented milk (BFM) containing live bifidobacteria is more effective than the usual treatment in inducing [7] and maintaining remission [8] of ulcerative colitis. An improvement in the composition of intestinal flora by BFM may prevent the overgrowth of potentially pathogenic bacteria such as Bacteroides vulgatus, but we hypothesized that probiotic strains of bifidobacteria in BFM may directly interfere with the host signaling events that drive the intestinal inflammatory response.…”

The long-term effects of probiotics in the therapy of ulcerative colitis: A clinical study

“…similarly, Kato et al (ref. 31 ) found increased levels of faecal butyrate, propionate, and scFa acid concentrations in patients with active Uc (mild to moderate), who received BFm together with conventional treatment. in this pilot study, patients supplemented with BFm showed a significantly lower clinical activity index than the placebo group.…”

Sepsis, the Liver and the Gut

“…[149] Following a systematic review of studies using VSL#3 TM , E.coli Nissle 1917 and Yakult TM , Mallon et al concluded that the addition of probiotics to conventional medical therapy had no effect in overall remission rate in mild to moderate UC. [150][151][152] Other randomized controlled trials have also shown conflicting results with some showing a higher rate of remission (with VSL#3 or a combination of a prebiotic and B.longum) [153][154][155] and others showing little or no benefit (with E.coli Nissle 1917). [156] There are no recommendations regarding the use of probiotics as maintenance therapy in UC.…”