Randomized Double-blind Trial of Treatment of Vitiligo

Yones, Sami Sasi; Palmer, Roy A.; Garibaldinos, Trish; Hawk, J.L.M.

doi:10.1001/archderm.143.5.578

Cited by 172 publications

(47 citation statements)

References 37 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…5 patients (16.66%) showed somewhat darker and 3 (10%) patients showed somewhat lighter colour in the patches of vitiligo after NBUVB phototherapy. This is in concordance with the results of earlier studies [11, 23, 24]. …”

Section: Discussionsupporting

confidence: 94%

Correlation of Vitamin D Levels with Pigmentation in Vitiligo Patients Treated with NBUVB Therapy

et al. 2014

View full text Add to dashboard Cite

Cholecalciferol (vitamin D) might play a physiological role in photo-induced melanogenesis in human skin. We estimated the levels of 25-hydroxy vitamin D [25(OH)D] before, during, and after Narrow Band Ultraviolet B (NBUVB) radiation in patients of vitiligo and their correlation with NBUVB induced pigmentation. Thirty patients of vitiligo and equal number of age and sex matched controls were recruited for the study. Vitiligo patients were treated with NBUVB thrice weekly for 12 weeks. [25(OH)D] levels and Vitiligo Area and Severity Index (VASI) were calculated at 0 (baseline), 6, and 12 weeks. Baseline [25(OH)D] levels were measured in controls. Significant reduction in VASI score was observed after 12 weeks of therapy. Comparison and correlation between mean improvement in VASI and [25(OH)D] levels at 12 weeks showed moderate correlation, and the results were statistically insignificant. Mean reduction in VASI and increase in [25(OH)D] levels after 12 weeks of NBUVB showed moderate correlation. Thus, vitamin D might play a significant role in photo-induced melanogenesis. However, there might be additional effects of the phototherapy on melanogenesis. The complete mechanism of NBUVB induced pigmentation in vitiligo needs to be elucidated.

show abstract

Section: Discussionsupporting

confidence: 94%

Correlation of Vitamin D Levels with Pigmentation in Vitiligo Patients Treated with NBUVB Therapy

et al. 2014

View full text Add to dashboard Cite

show abstract

“…On reviewing the literature, some studies evaluated the clinical response of NB‐UVB phototherapy in vitiligo patients after 6 months of starting therapy and other studies were extended up to 1 year. In the former studies, 5% (14), 34% (15) and 50% (16) patients achieved a marked response. Meanwhile, in the extended studies the percentage of marked improvement was much higher i.e.…”

Section: Discussionmentioning

confidence: 91%

Effect of one session of ER:YAG laser ablation plus topical 5Fluorouracil on the outcome of short‐term NB‐UVB phototherapy in the treatment of non‐segmental vitiligo: a left–right comparative study

Anbar

Westerhof²,

Abdel‐Rahman

et al. 2008

Photoderm Photoimm Photomed

View full text Add to dashboard Cite

show abstract

“…A light exposure (PUVA) and narrow band ultraviolet B rays (NBUVB) are widely used in phototherapy of vitiligo, though these are not free of drawbacks like cost and frequency of treatment, exposure to ultraviolet rays in specialized chambers in hospital or clinic setup and the uncertainty of repigmentation. NBUVB is found to be superior to PUVA due to various reasons[45] including better repigmentation and color match with natural skin, a better safety profile as it maximizes the delivery of narrow-band UVB radiation in the range of 312-313 nm which is the most beneficial of the UV spectrum, while minimizing exposure to superfluous UV radiation thereby considerably decreasing the risk of severe burning or pathogenic exposure to UV in harmful ranges. It also avoids the adverse side effects of the psoralens used in conventional PUVA therapy.…”

Section: Discussionmentioning

confidence: 99%

Phototherapy in vitiligo: Assessing the compliance, response and patient′s perception about disease and treatment

et al. 2013

View full text Add to dashboard Cite

Context:Vitiligo is a chronic, benign, but emotionally frustrating autoimmune disorder of depigmentation, with an incidence of 0.25-2.5% in India, the treatment of which is equally frustrating to the patient, as well as the doctor. Phototherapy is the first line treatment in many cases, which needs to be given at frequent sittings for long periods of time. As there is no satisfactory, short term treatment, many vitiligo patients, though enthusiastic in the beginning, become defaulters after a few weeks or months.Aims:This study was conducted to assess the compliance to phototherapy (PUVA and NB-UVB), determine the reasons for non-compliance, to calculate the overall response to phototherapy and to know about the patients’ perception about improvement of lesions.Materials and Methods:All files of the patients who attended phototherapy for Vitiligo in the department for a period of 4 years from January 2007 were analyzed and the patients were contacted via mail or telephone and were made to answer questionnaire regarding their disease.Conclusions:At the end of this retrospective questionnaire based study we concluded that only a quarter of the patients underwent regular phototherapy, among which the younger patients and those with widespread disease and facial lesions were more compliant. Educational status and sex had no impact on default status.

show abstract

Randomized Double-blind Trial of Treatment of Vitiligo

Cited by 172 publications

References 37 publications

Correlation of Vitamin D Levels with Pigmentation in Vitiligo Patients Treated with NBUVB Therapy

Correlation of Vitamin D Levels with Pigmentation in Vitiligo Patients Treated with NBUVB Therapy

Effect of one session of ER:YAG laser ablation plus topical 5Fluorouracil on the outcome of short‐term NB‐UVB phototherapy in the treatment of non‐segmental vitiligo: a left–right comparative study

Phototherapy in vitiligo: Assessing the compliance, response and patient′s perception about disease and treatment

Contact Info

Product

Resources

About