Randomized controlled trial of Ringer solution versus serum for partial exchange transfusion in neonatal polycythaemia

Abstract

PET with Ringer solution resulted in a haemodilution comparable to PET with serum and a correction of hypervolaemia.

Neonatal polycythaemia: critical review and a consensus statement of the Israeli Neonatology Association

“…(52), comparing plasma to NS, Roithmaier et al. (53) comparing plasma to Ringer lactate, Wong et al. (54) comparing albumin to NS, Krishnan and Rahim (55) comparing plasma to NS, and Jan et al.…”

Restrictive Management of Neonatal Polycythemia

“…In clinical settings, PET is commonly administered when hematocrit exceeds 69% or in symptomatic neonates with hematocrit of !65%. 17,18 In the present study, asymptomatic neonates with hematocrit of 65 to 69% were conservatively observed, and those with hematocrit of 70 to 75% were treated with IV fluids and NPO. PET was administered only when hematocrit exceeded 75% or when early symptoms occurred.…”

“…16 In clinical settings, however, PET is commonly performed when hematocrit exceeds 69% or in symptomatic neonates with hematocrit !65%. 17,18 This approach is based on studies that have shown an association between polycythemia and impaired long-term developmental outcome as well as on those in which PET has been shown to reduce pulmonary vascular resistance and increase cerebral blood flow. 2,3,19 Nevertheless, PET has not been shown to improve long-term developmental or neurological outcomes.…”

Crystalloid or colloid for partial exchange transfusion in neonatal polycythemia: A systematic review and meta‐analysis

“…We identified a total of six studies which appeared to be randomized, controlled trials of a crystalloid solution versus a colloid solution for partial exchange transfusion (Torre 1988 [11], Deorari 1995 [12], Roithmaier 1995 [13], Wong 1997 [14], Krishnan 1997 [15], and Supapannachart 1999 [16]) in the polycythemic newborn.…”