Let X(t) be a continuously time-changed Brownian motion starting from a random position η, S(t) a given continuous, increasing boundary, with S(0) ≥ 0, P(η ≥ S(0)) = 1, and F an assigned distribution function. We study the inverse first-passage time problem for X(t), which consists in finding the distribution of η such that the first-passage time of X(t) below S(t) has distribution F, generalizing the results, valid in the case when S(t) is a straight line. Some explicit examples are reported.