Randomization and allocation concealment: a practical guide for researchers

Doig, Gordon S.; Simpson, F. O.

doi:10.1016/j.jcrc.2005.04.005

Cited by 516 publications

(360 citation statements)

References 11 publications

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“…The patients were randomised into study, and control groups using sequentially numbered, opaque sealed envelopes that were accessed at the indexed procedures [7].…”

Section: Methodsmentioning

confidence: 99%

Smart-Draping-A Validated Novice Technique to Prevent Drapes Peeling off During Hip Fracture Fixation Surgery: A Prospective Randomized Controlled Study

Hussainy¹

2017

J Trauma Treat

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The contamination of the surgical field can be a potential risk of infection that can be devastating to patients undergoing hip fracture fixation surgery. Drapes peeling off during such operation is a recognised challenge that can lead to such a contamination. We describe and validate a simple technique to prevent drapes peeling off the operative field during hip fracture fixation surgery using the smart-draping technique. The smart-draping entails applying a sterile disposable single large adhesive op-sheet to the inferior aspect of the thigh, just under the proposed surgical incision, followed by applying the usual plastic vertical isolation drape. Fourteen neck-of-femur fracture patients undergoing dynamic hip screw (DHS) fixation were recruited and randomised into study and control groups to measure fluid leakage, as an indirect measurement of the vertical drapes peeling off the surgical site. Incontinence pads were placed on the floor to collect all leaked fluid in all patients. The average weight of the fluid collected in the study groups was 11.4 gm (SD ± 12.1) while that of the control group was 354.3 gm (SD ± 175). There was a statistical significant difference between the two methods favouring the smart-draping method over the control one. (P<0.001) We conclude that smart-draping technique will make it harder for the drapes to peel off thus, avoiding the potential contamination of the surgical field and ultimately avoiding potential infection of the surgical site in hip fracture fixation surgery.

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“…The patients were randomised into study, and control groups using sequentially numbered, opaque sealed envelopes that were accessed at the indexed procedures [7].…”

Section: Methodsmentioning

confidence: 99%

Smart-Draping-A Validated Novice Technique to Prevent Drapes Peeling off During Hip Fracture Fixation Surgery: A Prospective Randomized Controlled Study

Hussainy¹

2017

J Trauma Treat

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“…eighty patients were selected for this study. Patients were randomly divided into four groups, according to the method described by Doig and Simp-son 27 . the following inclusion criteria were used: ages between 18 and 50 years, physical status ASA i or ii, body mass index (BMi) between 18 and 27 kg.m -2 , absence of medication that could interfere with the neuromuscular blockade, absence of hepatic of renal dysfunction, and absence of neuromuscular disease.…”

Section: Methodsmentioning

confidence: 99%

Efeito da utilização de 2 mg.kg-1 de lidocaína endovenosa na latência de duas doses diferentes de rocurônio e na resposta hemodinâmica à intubação traqueal

Vivancos¹,

Klamt²,

Garcia³

2011

Rev. Bras. Anestesiol.

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Summary: Vivancos GG, Klamt JG, Garcia lV -effects of 2 mg.kg -1 of intravenous lidocaine on the latency of two Different Doses of Rocuronium and on the Hemodynamic Response of Orotracheal intubation.Background and objectives: lidocaine potentiates the effects of neuromuscular blockers and attenuates the hemodynamic response to orotracheal intubation. the objective of the present study was to test the effects of lidocaine on the latency of two different doses of rocuronium and on the hemodynamic response to intubation.

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“…Using the SNOSE method [11], treatments are randomly concealed within opaque sealed envelopes and sequentially assigned to participants as they enrol in the trial. However, this method has been shown to be prone to tampering [9,12].…”

Section: Journal Of Health and Medical Informaticsmentioning

confidence: 99%

Design of a Smartphone Application with Integrated Functional Electrical Stimulation (FES) Treatment Randomization and On-The-Fly Stimulus Parameter Adjustment for Streamlining the Clinical Evaluation of FES Protocols

Sweeney¹,

Corley²,

Browne³

et al. 2016

J Health Med Inform

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The clinical application of Functional Electrical Stimulation (FES) has evolved over the last five decades. However, the use of the Randomized Control Trial (RCT) methodology in evaluating the clinical effectiveness of new and existing applications of FES is a demanding process adding time and cost to these trials. Consequently, there has been a low level of RCTs applied to FES studies. Poor quality trials result in poor evidence of FES effectiveness with a consequence that the technique may not be adopted into clinical practice. In this paper some of the key challenges encountered in FES randomised control clinical trials are identified and a solution to address these challenges is presented in the form of a smartphone App and a Bluetooth controlled FES architecture. The design and evaluation of a smartphone application using a User Centred Design approach to provide automatic blind randomization control and facilitating the wireless temporal control of a portable Bluetooth enabled FES device is described.

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Randomization and allocation concealment: a practical guide for researchers

Cited by 516 publications

References 11 publications

Smart-Draping-A Validated Novice Technique to Prevent Drapes Peeling off During Hip Fracture Fixation Surgery: A Prospective Randomized Controlled Study

Smart-Draping-A Validated Novice Technique to Prevent Drapes Peeling off During Hip Fracture Fixation Surgery: A Prospective Randomized Controlled Study

Efeito da utilização de 2 mg.kg-1 de lidocaína endovenosa na latência de duas doses diferentes de rocurônio e na resposta hemodinâmica à intubação traqueal

Design of a Smartphone Application with Integrated Functional Electrical Stimulation (FES) Treatment Randomization and On-The-Fly Stimulus Parameter Adjustment for Streamlining the Clinical Evaluation of FES Protocols

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