Randomised trial to assess safety and fetal outcome of early and midtrimester amniocentesis

Wilson, R. D.; Johnson, Jo‐Ann; Dansereau, Jerome; Singer, Joel; Drinnan, S. L.; Winsor, Elizabeth J.T.; Soanes, S.; Kalousek, Dagmar K.; Hillier, J.; Ho, Margaret T.; Brown, Jennifer; Wyatt, Philip; Farrell, S. A.; O'Farrell, J.; Chadwick, Derek; Natale, Renato; Mitchell, Courtney; Fan, Yao Shan; Mohide, Patrick; Beecroft, Mary Louise; Tomkins, Darrell J.; Carter, R.; Benzie, R.; Maclean, Barbara J.; Wang, H. S.; Dallaire, Louis; Desrochers, Micheline; Tihy, Frédérique; Eydoux, Patrice; Provencher, S.; Cartier, Lola; Armson, B. Anthony; Hogg, H.; Welch, John P.; Harman, C.; Babaian, Kara N.; Dawson, A. M.; Okun, Nanette; Park, M.; Lin, J. C. C.; Robinson, G.; Summers, Anne

doi:10.1016/s0140-6736(97)12346-7

Cited by 281 publications

(7 citation statements)

References 18 publications

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“…More recently, with the widespread introduction of an ultrasound scan at 11-13 weeks' gestation, as part of early screening for fetal aneuploidies, many cases of TRAP sequence are now diagnosed during the first trimester of pregnancy [80]. Despite this earlier diagnosis, intrauterine therapeutic interventions were delayed until after 15 weeks' gestation, because the risks of amniorrhexis and miscarriage were considered to be too high if carried out before obliteration of the celomic cavity [81,82,83]. …”

Section: Discussionmentioning

confidence: 99%

Optimal Method and Timing of Intrauterine Intervention in Twin Reversed Arterial Perfusion Sequence: Case Study and Meta-Analysis

et al. 2014

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Introduction: The objective of this study was to define the optimal method and timing of intervention in twin reversed arterial perfusion (TRAP) sequence. Material and Methods: During a period of 20 years (1993-2013), we performed endoscopic laser coagulation of umbilical cord vessels or intrafetal laser in 67 pregnancies with TRAP sequence. These data were combined with those reported in the literature to determine the survival rate of the pump twin for different methods and timing of interventions. Results: A variety of techniques were used to interrupt the blood supply to the acardiac twin. Most procedures were performed at or after 16 weeks, and with most methods the survival rate of the pump twin was about 80%. Good results were also obtained for triplet pregnancies. In 18 of 30 cases (60%) diagnosed at 11-14 weeks, there was spontaneous cessation of flow in the acardiac twin before planned intervention at 16-18 weeks, and in 11 of these (61.1%) the pump twin died or suffered brain damage. In 103 pregnancies treated by intrafetal laser at 12-27 weeks, there was no correlation between gestational age at treatment and survival rate, but there was an inverse association between gestational age at treatment and gestational age at birth. Discussion: In TRAP sequence, survival may be improved by elective intervention at 12-14 weeks.

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Section: Discussionmentioning

confidence: 99%

Optimal Method and Timing of Intrauterine Intervention in Twin Reversed Arterial Perfusion Sequence: Case Study and Meta-Analysis

et al. 2014

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“…There is almost no data in general with regard to neonatal morbidity and mortality after first trimester or PPROM at under 24 weeks of gestation. However, when examining evidence from early amniocentesis studies, it is possible to infer risk for talipes equinovarus [ 10 ] in addition to fetal demise [ 10 ]. These studies were intended to assess the safety of early amniocentesis (<13 weeks) in comparison with midtrimester amniocentesis (14–16 weeks).…”

Section: Discussionmentioning

confidence: 99%

“…These studies were intended to assess the safety of early amniocentesis (<13 weeks) in comparison with midtrimester amniocentesis (14–16 weeks). Researchers found an increased incidence of fetal loss (7.6% vs 5.9% p = 0.012) as well as an increased risk for talipes equinovarus in the early amniocentesis group (1.3% vs 0.1% p = 0.0001) [ 10 ]. This association regarding limb deformities has carried over with regard to complications from CVS; however, anomalies, transverse digital deficiencies in particular, increase in significance with sampling prior to 9–11 weeks of gestation [ 11 ] and is comparable to the incidence in the population at large [ 12 ].…”

Section: Discussionmentioning

confidence: 99%

Preterm prelabor rupture of membranes after first-trimester chorionic villus sampling: A case report and review of the literature

Early,

Arrabal

2024

Case Reports in Women's Health

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“…The rates of spontaneous miscarriage (3.6% vs 2.5%; average relative risk [RR] 1.41, 95% CI 1.00-1.98) and fetal limb anomalies (4.7% vs 2.7%; average RR 1.73, 95% CI 1.26-2.38) are higher when amniocentesis is performed before 15 weeks of gestation. 3,[17][18][19] Several recent systematic reviews and meta-analyses reiterate the safety of both procedures regarding spontaneous pregnancy loss postprocedure and found no statistically significant difference when comparing transabdominal CVS with second-trimester amniocentesis (3.0% vs 3.9%; average RR 0.77, 95% CI 0.49-1.21). [18][19][20] Of the 13 states with total bans on abortion, five have specific legislation prohibiting abortion when the fetus is found to have an abnormality.…”

Section: Proposed Framework For Addressing Prenatal Genetic Testing I...mentioning

confidence: 99%

Implications for Prenatal Genetic Testing in the United States After the Reversal of Roe v Wade

Raymond

Barbera

Boudova

et al. 2023

Obstetrics &Amp; Gynecology

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The purpose of this chapter is to protect unborn human life and maternal health within present constitutional limits. It reaffirms the tradition of the state of North Dakota to protect every human life whether unborn or aged, healthy or sick. 14-02.1-02. Definitions.As used in this chapter: 1. "Abortion" means the act of using or prescribing any instrument, medicine, drug, or any other substance, device, or means with the intent to terminate the clinically diagnosable intrauterine pregnancy of a woman, including the elimination of one or more unborn children in a multifetal pregnancy, with knowledge that the termination by those means will with reasonable likelihood cause the death of the unborn child. Such use, prescription, or means is not an abortion if done with the intent to: a. Save the life or preserve the health of the unborn child; b. Remove a dead unborn child caused by spontaneous abortion; or c. Treat a woman for an ectopic pregnancy. 2. "Abortion facility" means a clinic, ambulatory surgical center, physician's office, or any other place or facility in which abortions are performed or prescribed, other than a hospital. 3. "Abortion-inducing drug" means a medicine, drug, or any other substance prescribed or dispensed with the intent of causing an abortion. 4. "Down syndrome" refers to a chromosome disorder associated with an extra chromosome twenty-one, in whole or in part, or an effective trisomy for chromosome twenty-one. 5. "Drug label" means the pamphlet accompanying an abortion-inducing drug which outlines the protocol tested and authorized by the federal food and drug administration and agreed upon by the drug company applying for the federal food and drug administration authorization of that drug. Also known as "final printing labeling instructions", drug label is the federal food and drug administration document that delineates how a drug is to be used according to the federal food and drug administration approval. 6. "Fertilization" means the fusion of a human spermatozoon with a human ovum. 7. "Genetic abnormality" means any defect, disease, or disorder that is inherited genetically. The term includes any physical disfigurement, scoliosis, dwarfism, Down syndrome, albinism, amelia, or any other type of physical or mental disability, abnormality, or disease. 8. "Hospital" means an institution licensed by the department of health and human services under chapter 23-16 and any hospital operated by the United States or this state. 9. "Human being" means an individual living member of the species of homo sapiens, including the unborn human being during the entire embryonic and fetal ages from fertilization to full gestation. 10. "Infant born alive" means a born child which exhibits either heartbeat, spontaneous respiratory activity, spontaneous movement of voluntary muscles or pulsation of the umbilical cord if still attached to the child. 11. "Informed consent" means voluntary consent to abortion by the woman upon whom the abortion is to be performed or induced provided: a. The woman is told the...

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Randomised trial to assess safety and fetal outcome of early and midtrimester amniocentesis

Cited by 281 publications

References 18 publications

Optimal Method and Timing of Intrauterine Intervention in Twin Reversed Arterial Perfusion Sequence: Case Study and Meta-Analysis

Optimal Method and Timing of Intrauterine Intervention in Twin Reversed Arterial Perfusion Sequence: Case Study and Meta-Analysis

Preterm prelabor rupture of membranes after first-trimester chorionic villus sampling: A case report and review of the literature

Implications for Prenatal Genetic Testing in the United States After the Reversal of Roe v Wade

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