Randomised placebo-controlled crossover trial on effect of inactivated influenza vaccine on pulmonary function in asthma

Nicholson, Karl G.; Nguyen-Van-Tam, Jonathan S.; Ahmed, A. H. M.; Wiselka, Martin; Leese, Jane; Ayres, Jon G.; Campbell, James H.; Ebden, P; Eiser, Noemi M.; Hutchcroft, B. J.; Pearson, Jennifer; Willey, R F; Wolstenholme, Roger J; Woodhead, Mark

doi:10.1016/s0140-6736(97)07468-0

Cited by 90 publications

(48 citation statements)

References 28 publications

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“…Patients with moderate-to-severe asthma should be advised to receive an influenza vaccination every year [254], or at least when vaccination of the general population is advised. However, routine influenza vaccination of children [255] and adults [256] with asthma does not appear to protect them from asthma exacerbations or improve asthma control.…”

Section: Influenza Vaccinationmentioning

confidence: 99%

Global strategy for asthma management and prevention: GINA executive summary

Bateman

Ss²,

Barnes³

et al. 2008

European Respiratory Journal

2,641

2,301

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Asthma is a serious health problem throughout the world. During the past two decades, many scientific advances have improved our understanding of asthma and ability to manage and control it effectively. However, recommendations for asthma care need to be adapted to local conditions, resources and services. Since it was formed in 1993, the Global Initiative for Asthma, a network of individuals, organisations and public health officials, has played a leading role in disseminating information about the care of patients with asthma based on a process of continuous review of published scientific investigations. A comprehensive workshop report entitled ''A Global Strategy for Asthma Management and Prevention'', first published in 1995, has been widely adopted, translated and reproduced, and forms the basis for many national guidelines. The 2006 report contains important new themes. First, it asserts that ''it is reasonable to expect that in most patients with asthma, control of the disease can and should be achieved and maintained,'' and recommends a change in approach to asthma management, with asthma control, rather than asthma severity, being the focus of treatment decisions. The importance of the patient-care giver partnership and guided self-management, along with setting goals for treatment, are also emphasised.

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Section: Influenza Vaccinationmentioning

confidence: 99%

Global strategy for asthma management and prevention: GINA executive summary

Bateman

Ss²,

Barnes³

et al. 2008

European Respiratory Journal

2,641

2,301

View full text Add to dashboard Cite

show abstract

“…Only myalgia was reported more frequently following IIV3 (25% versus 21% placebo; p<0.001) (374). A randomized study of IIV3 versus placebo among 262 asthmatic adults noted that vaccination was associated with a decline in peak expiratory flow; however, this effect was no longer significant when adjusted for the presence of concomitant symptomatic cold symptoms (375). A randomized crossover design study of IIV3 versus saline placebo showed no significant difference in the occurrence of asthma exacerbations during the 14 days postvaccination (376).…”

Section: Persons At Higher Risk For Influenza-related Complicationsmentioning

confidence: 99%

Prevention and Control of Seasonal Influenza with Vaccines

Grohskopf

Sokolow²,

Broder³

et al. 2016

MMWR Recomm. Rep.

381

279

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“…[32][33][34][35][36][37][38][39] One well-controlled study was performed using the computerized records of children born between 1991 and 1997 who were enrolled in 4 large health maintenance organizations (HMOs). 32 This cohort was used to identify 18 407 children with asthma.…”

Section: Clinical Studies Evaluating the Relationship Between Vaccinementioning

confidence: 99%

Addressing Parents’ Concerns: Do Vaccines Cause Allergic or Autoimmune Diseases?

Offit

Hackett

2003

Pediatrics

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ABSTRACT. Anecdotal case reports and uncontrolled observational studies in the medical literature claim that vaccines cause chronic diseases such as asthma, multiple sclerosis, chronic arthritis, and diabetes. Several biological mechanisms have been proposed to explain how vaccines might cause allergic or autoimmune diseases. For example, allergic diseases might be caused by prevention of early childhood infections (the "hygiene hypothesis"), causing a prolongation of immunoglobulin E-promoting T-helper cell type 2-type responses. However, vaccines do not prevent most common childhood infections, and large well-controlled epidemiologic studies do not support the hypothesis that vaccines cause allergies. Autoimmune diseases might occur after immunization because proteins on microbial pathogens are similar to human proteins ("molecular mimicry") and could induce immune responses that damage human cells. However, wild-type viruses and bacteria are much better adapted to growth in humans than vaccines and much more likely to stimulate potentially damaging selfreactive lymphocytes. Consistent with critical differences between natural infection and immunization, well-controlled epidemiologic studies do not support the hypothesis that vaccines cause autoimmunity.Flaws in proposed biological mechanisms that explain how vaccines might cause chronic diseases are consistent with the findings of many well-controlled large epidemiologic studies that fail to show a causal relationship.

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Randomised placebo-controlled crossover trial on effect of inactivated influenza vaccine on pulmonary function in asthma

Cited by 90 publications

References 28 publications

Global strategy for asthma management and prevention: GINA executive summary

Global strategy for asthma management and prevention: GINA executive summary

Prevention and Control of Seasonal Influenza with Vaccines

Addressing Parents’ Concerns: Do Vaccines Cause Allergic or Autoimmune Diseases?

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