RANBP1 promotes colorectal cancer progression by regulating pre-miRNA nuclear export via a positive feedback loop with YAP

Zheng, Dandan; Cao, Meng; Zuo, Siyu; Xia, Xuejun; Zhi, Chunchun; Lin, Yanbing; Deng, Sitong; Yuan, Xiaoqin

doi:10.1038/s41388-021-02036-5

Cited by 8 publications

(6 citation statements)

References 35 publications

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“…Several researchers have reported that RanBP1 is involved in cancer malignancy [ 33 ]. In particular, RanBP1 is known to be involved in cancer induction by regulating pre-miRNA nuclear export [ 34 ]. Further experiments will investigate the relationship with the pre-miRNA regulated by RanBP1 and analyze its function.…”

Section: Discussionmentioning

confidence: 99%

RanBP1: A Potential Therapeutic Target for Cancer Stem Cells in Lung Cancer and Glioma

Kahm

Kim

2023

IJMS

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Cancer stem cells (CSCs) are known to be one of the factors that make cancer treatment difficult. Many researchers are thus conducting research to efficiently destroy CSCs. Therefore, we sought to suggest a new target that can efficiently suppress CSCs. In this study, we observed a high expression of Ran-binding protein 1 (RanBP1) in lung cancer stem cells (LCSCs) and glioma stem cells (GSCs). Upregulated RanBP1 expression is strongly associated with the expression of CSC marker proteins and CSC regulators. In addition, an elevated RanBP1 expression is strongly associated with a poor patient prognosis. CSCs have the ability to resist radiation, and RanBP1 regulates this ability. RanBP1 also affects the metastasis-associated epithelial–mesenchymal transition (EMT) phenomenon. EMT marker proteins and regulatory proteins are affected by RanBP1 expression, and cell motility was regulated according to RanBP1 expression. The cancer microenvironment influences cancer growth, metastasis, and cancer treatment. RanBP1 can modulate the cancer microenvironment by regulating the cytokine IL-18. Secreted IL-18 acts on cancer cells and promotes cancer malignancy. Our results reveal, for the first time, that RanBP1 is an important regulator in LCSCs and GSCs, suggesting that it holds potential for use as a potential therapeutic target.

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Section: Discussionmentioning

confidence: 99%

RanBP1: A Potential Therapeutic Target for Cancer Stem Cells in Lung Cancer and Glioma

Kahm

Kim

2023

IJMS

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“…This facilitates the pre-miRNAs to accumulate in the nucleus, which lowers the amount of mature miRNA present. Evidence suggests that RANBP1 modulates pre-miRNA nuclear transportation to affect colorectal cancer cell proliferation, invasion, and apoptosis (63). Fungal virulence in plants depends on the secretory protein VdSSR1 (secreted silencing blocker 1), which is produced from Flavobacterium flavum.…”

Section: The Mechanism Of Nuclear Mirnasmentioning

confidence: 99%

Recent advances in the functional explorations of nuclear microRNAs

Yin

Zhang

et al. 2023

Front. Immunol.

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Approximately 22 nucleotide-long non-coding small RNAs (ncRNAs) play crucial roles in physiological and pathological activities, including microRNAs (miRNAs). Long ncRNAs often stay in the cytoplasm, modulating post-transcriptional gene expression. Briefly, miRNA binds with the target mRNA and builds a miRNA-induced silencing complex to silence the transcripts or prevent their translation. Interestingly, data from recent animal and plant studies suggested that mature miRNAs are present in the nucleus, where they regulate transcriptionally whether genes are activated or silenced. This significantly broadens the functional range of miRNAs. Here, we reviewed and summarized studies on the functions of nuclear miRNAs to better understand the modulatory networks associated with nuclear miRNAs.

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“…Note how strikingly different the 5 -tRH profiles are between the colon cancer patient samples of project PRJNA397121 [39] and the colon cancer cell lines (all other projects). The richness of 5 -tRHs found in the patients is replaced by a single abundant tRNA half in the cell lines or is missing altogether; e.g., project PRJNA748887 [40].…”

Section: The Abundances Of Different-length 5 -Trhs Depend On Contextmentioning

confidence: 99%

The Typical tRNA Co-Expresses Multiple 5′ tRNA Halves Whose Sequences and Abundances Depend on Isodecoder and Isoacceptor and Change with Tissue Type, Cell Type, and Disease

Akins,

Ostberg,

Cherlin

et al. 2023

ncRNA

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Transfer RNA-derived fragments (tRFs) are noncoding RNAs that arise from either mature transfer RNAs (tRNAs) or their precursors. One important category of tRFs comprises the tRNA halves, which are generated through cleavage at the anticodon. A given tRNA typically gives rise to several co-expressed 5’-tRNA halves (5′-tRHs) that differ in the location of their 3′ ends. These 5′-tRHs, even though distinct, have traditionally been treated as indistinguishable from one another due to their near-identical sequences and lengths. We focused on co-expressed 5′-tRHs that arise from the same tRNA and systematically examined their exact sequences and abundances across 10 different human tissues. To this end, we manually curated and analyzed several hundred human RNA-seq datasets from NCBI’s Sequence Run Archive (SRA). We grouped datasets from the same tissue into their own collection and examined each group separately. We found that a given tRNA produces different groups of co-expressed 5′-tRHs in different tissues, different cell lines, and different diseases. Importantly, the co-expressed 5′-tRHs differ in their sequences, absolute abundances, and relative abundances, even among tRNAs with near-identical sequences from the same isodecoder or isoacceptor group. The findings suggest that co-expressed 5′-tRHs that are produced from the same tRNA or closely related tRNAs have distinct, context-dependent roles. Moreover, our analyses show that cell lines modeling the same tissue type and disease may not be interchangeable when it comes to experimenting with tRFs.

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RANBP1 promotes colorectal cancer progression by regulating pre-miRNA nuclear export via a positive feedback loop with YAP

Cited by 8 publications

References 35 publications

RanBP1: A Potential Therapeutic Target for Cancer Stem Cells in Lung Cancer and Glioma

RanBP1: A Potential Therapeutic Target for Cancer Stem Cells in Lung Cancer and Glioma

Recent advances in the functional explorations of nuclear microRNAs

The Typical tRNA Co-Expresses Multiple 5′ tRNA Halves Whose Sequences and Abundances Depend on Isodecoder and Isoacceptor and Change with Tissue Type, Cell Type, and Disease

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