Radiotherapy in the management of epidemic Kaposi's sarcoma of the oral cavity, the eyelid and the genitals

Bourgeois, J. P. Le; Frikha, H.; Piedbois, Pascal; Péchoux, C. Le; Martin, Laurent; Haddad, Elias

doi:10.1016/0167-8140(94)90467-7

Cited by 53 publications

(24 citation statements)

References 16 publications

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“…Treatment is then directed at improving antiviral medication which will eradicate the KS lesions. Persistent small lesions on the external genitalia are best treated with repeated cryotherapy [62] and larger areas with radiotherapy [63,64].…”

Section: Malignancymentioning

confidence: 99%

The urologist and the patient infected with human immunodeficiency virus or with acquired immunodeficiency syndrome

2001

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Section: Malignancymentioning

confidence: 99%

The urologist and the patient infected with human immunodeficiency virus or with acquired immunodeficiency syndrome

2001

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“…Even though the percentage of acquired immune deficiency syndrome (AIDS) patients with KS is decreasing, the overall incidence of epidemic KS is increasing along with the rising prevalence of AIDS (3) . It has been well established that KS is responsive to radiation therapy, and in response various radiation treatment schemes have been studied 1 , 2 , 3 , 4 , 5 , 6 , 7 , 8 , 9 , 10 , 11 , 12 , 13 . The response rate of KS in epidemic form to radiation therapy has been demonstrated to be as high as 90%, and it has been proven that radiation therapy shows better symptomatic control than chemotherapy (14) …”

Section: Introductionmentioning

confidence: 99%

Evaluation of treatment plans using various treatment techniques for the radiotherapy of cutaneous Kaposi's sarcoma developed on the skin of feet

Park

Kim

et al. 2014

J Applied Clin Med Phys

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The purpose of this study was to investigate the plan qualities of various treatment modalities for the radiotherapy of cutaneous Kaposi's sarcoma developed on the skin of the foot. A total of six virtual targets were generated on the skin of the foot in CT images. Five types of treatment plans were generated using photon beams (PB), electron beams (EB), high‐dose‐rate (HDR) brachytherapy with a Freiburg flap applicator, intensity‐modulated radiation therapy (IMRT), and volumetric‐modulated arc therapy (VMAT) techniques. Plans for each of the six targets (single‐target plans) and also for the combined target consisting of the six single targets combined (multitarget plans) were generated. Dose‐volumetric analysis was performed for the targets and normal tissues. The averaged conformity index (CI) and homogeneity index (HI) values for each single target using PB, EB, HDR, IMRT, and VMAT techniques were 1.97, 2.39, 1.60, 4.60, and 0.80 and 1.05, 1.11, 1.52, 1.04, and 1.04, respectively. For the multitarget, the CI values were 3.99, 5.08, 1.38, 1.95, and 0.84, and the values of HI were 1.10, 1.36, 1.43, 1.06, and 1.04, respectively. The averaged mean doses to normal tissue were 2.5, 2.7, 3.6, 1.7, and 2.9 Gy for single‐target plans, and 21.3, 14.6, 14.2, 14.3, and 13.0 Gy for the multitarget plans, respectively. The VMAT demonstrated dosimetric advantages and better treatment efficiency over other techniques for the radiotherapy of multifocal skin disease of the feet.PACS number: 87.55.dk

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“…Irradiation of symptomatic oropharyngeal lesions has been problematic because these patients experience a high degree of radiation-induced mucositis even after low-dose irradiation therapy [27]. For example, in 27 patients receiving 15 Gy, severe reactions were observed in 6 (22%), moderate reactions in 4 (15%) and mild reactions in 17 (63%) [24]. As alternative treatment, a HDR brachytherapy technique was described with a median dose of 24 Gy in 3 fractions with complete response of all lesions, only mild mucositis and no relapse [13,14].…”

Section: Radiation Therapymentioning

confidence: 99%

“…Long-standing and dark purple lesions are more likely to leave residual pigment stains than relatively new, light purple lesions [19]. Eyelid and conjunctival KS seems to be more radiosensitive than cutaneous sites: a high objective remission rate of 96% was observed at doses ranging from 10 to 20 Gy, while penile and scrotal lesions showed a complete response rate of 70% with low-dose radiation [24]. Piedbois et al [25] reported an 88% objective response rate and 'good palliation of symptoms' after 10-20 Gy (2.5 Gy/fraction, 4 fractions per week) for delicate anatomic sites, such as the penis, palms, oral mucosa and conjunctivae.…”

Section: Radiation Therapymentioning

confidence: 99%

Radiotherapy in the Management of Kaposi’s Sarcoma

Becker

Bottke²

2006

Oncol Res Treat

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Of all types of Kaposi’s sarcoma (KS), only AIDS (acquired immunodeficiency syndrome)-related KS is of clinical importance, although its incidence has significantly declined in the last years. KS is considered a radiosensitive tumor, and good palliation of symptoms can be achieved with radiotherapy. Material and Methods: Evident radiotherapy data in the available literature were reviewed to analyze and evaluate indications, techniques, dose concepts and outcomes in radiation treatment of KS. Results: Good palliation of KS symptoms can be achieved by radiotherapy, with more than 90% response and 70% complete remission. For patients with far advanced AIDS, a single dose of 8 Gy is preferable. The following doses have been shown to be sufficient: 15 Gy for oral lesions, 20 Gy for lesions involving the eyelids, conjunctivae and genitals, 30-40 Gy in single doses of 2 Gy for cutaneous lesions. Side effects are rare, and radiation is usually well tolerated, with minimal skin reactions - except for patients with mucosa lesions, where a high degree of mucositis is often observed. Conclusion: Radiotherapy has its place in the management of KS as an efficient treatment, often representing the optimal local therapy for palliation of pain, bleeding or edema.

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Radiotherapy in the management of epidemic Kaposi's sarcoma of the oral cavity, the eyelid and the genitals

Cited by 53 publications

References 16 publications

The urologist and the patient infected with human immunodeficiency virus or with acquired immunodeficiency syndrome

The urologist and the patient infected with human immunodeficiency virus or with acquired immunodeficiency syndrome

Evaluation of treatment plans using various treatment techniques for the radiotherapy of cutaneous Kaposi's sarcoma developed on the skin of feet

Radiotherapy in the Management of Kaposi’s Sarcoma

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