Radiotherapy and the Treatment of Age-related Macular Degeneration ExternalBeam Radiation Therapy Is Effective in the Treatment of Age-related Macular Degeneration

Palladium-103 plaque radiation therapy for macular degeneration: results of a 7 year study

“…38 Irradiation of a macula containing classic or occult subretinal neovascularisation can directly affect angiogenesis by destroying neovascular endothelial cells and cytokine producing macrophages, or alter the regulatory genes which produce endothelial growth regulating cytokines. 39 Widely employed to prevent scar formation, radiation has been used to inhibit the cutaneous keloid and more recently proved to prevent coronary artery stenosis. 40 Similarly, Hart et al have suggested that radiotherapy inhibited disciform scar formation associated with end stage exudative macular degeneration.…”

Palladium-103 plaque radiation therapy for macular degeneration: results of a 7 year study

“…38 Irradiation of a macula containing classic or occult subretinal neovascularisation can directly affect angiogenesis by destroying neovascular endothelial cells and cytokine producing macrophages, or alter the regulatory genes which produce endothelial growth regulating cytokines. 39 Widely employed to prevent scar formation, radiation has been used to inhibit the cutaneous keloid and more recently proved to prevent coronary artery stenosis. 40 Similarly, Hart et al have suggested that radiotherapy inhibited disciform scar formation associated with end stage exudative macular degeneration.…”

Brachytherapy in Neovascular AMD

“…The role of radiation therapy for neovascular AMD was explored as early as 1993 in the form of external beam therapy [16], and it has been previously studied as a treatment for solid vascularized intraocular tumors as well [17][18][19][20][21][22][23]. The rationale for this approach was based on the known effects of radiation therapy on tumor microvasculature.…”

Differential Sensitivity of Choroidal Endothelial, Retinal Ganglion, and Retinal Pigment Epithelial Cells In Vitro to Proton Radiation

“…4,5 Proliferating endothelial cells present in CNV offer a potential target for radiation-based treatment. 6 Proton radiation, a form of particle radiation therapy, delivers a homogenous 3-dimensional dose to the target lesion with minimal damage to surrounding healthy tissues. 6 Unlike conventional radiation, ideally selected proton radiation dosage should destroy choroidal endothelial cells without damage to RPE cells or retinal ganglion cells.…”

“…6 Proton radiation, a form of particle radiation therapy, delivers a homogenous 3-dimensional dose to the target lesion with minimal damage to surrounding healthy tissues. 6 Unlike conventional radiation, ideally selected proton radiation dosage should destroy choroidal endothelial cells without damage to RPE cells or retinal ganglion cells. Recently, epimacular brachytherapy has been studied as a novel method to deliver radiation therapy directly to CNV.…”

Palladium-103 plaque radiation therapy for macular degeneration: results of a 7 year study

“…38 Irradiation of a macula containing classic or occult subretinal neovascularisation can directly affect angiogenesis by destroying neovascular endothelial cells and cytokine producing macrophages, or alter the regulatory genes which produce endothelial growth regulating cytokines. 39 Widely employed to prevent scar formation, radiation has been used to inhibit the cutaneous keloid and more recently proved to prevent coronary artery stenosis. 40 Similarly, Hart et al have suggested that radiotherapy inhibited disciform scar formation associated with end stage exudative macular degeneration.…”

Brachytherapy in Neovascular AMD

“…The role of radiation therapy for neovascular AMD was explored as early as 1993 in the form of external beam therapy [16], and it has been previously studied as a treatment for solid vascularized intraocular tumors as well [17][18][19][20][21][22][23]. The rationale for this approach was based on the known effects of radiation therapy on tumor microvasculature.…”

Differential Sensitivity of Choroidal Endothelial, Retinal Ganglion, and Retinal Pigment Epithelial Cells In Vitro to Proton Radiation

“…4,5 Proliferating endothelial cells present in CNV offer a potential target for radiation-based treatment. 6 Proton radiation, a form of particle radiation therapy, delivers a homogenous 3-dimensional dose to the target lesion with minimal damage to surrounding healthy tissues. 6 Unlike conventional radiation, ideally selected proton radiation dosage should destroy choroidal endothelial cells without damage to RPE cells or retinal ganglion cells.…”

“…6 Proton radiation, a form of particle radiation therapy, delivers a homogenous 3-dimensional dose to the target lesion with minimal damage to surrounding healthy tissues. 6 Unlike conventional radiation, ideally selected proton radiation dosage should destroy choroidal endothelial cells without damage to RPE cells or retinal ganglion cells. Recently, epimacular brachytherapy has been studied as a novel method to deliver radiation therapy directly to CNV.…”

Palladium-103 plaque radiation therapy for macular degeneration: results of a 7 year study

“…38 Irradiation of a macula containing classic or occult subretinal neovascularisation can directly affect angiogenesis by destroying neovascular endothelial cells and cytokine producing macrophages, or alter the regulatory genes which produce endothelial growth regulating cytokines. 39 Widely employed to prevent scar formation, radiation has been used to inhibit the cutaneous keloid and more recently proved to prevent coronary artery stenosis. 40 Similarly, Hart et al have suggested that radiotherapy inhibited disciform scar formation associated with end stage exudative macular degeneration.…”

Brachytherapy in Neovascular AMD

“…The role of radiation therapy for neovascular AMD was explored as early as 1993 in the form of external beam therapy [16], and it has been previously studied as a treatment for solid vascularized intraocular tumors as well [17][18][19][20][21][22][23]. The rationale for this approach was based on the known effects of radiation therapy on tumor microvasculature.…”

Differential Sensitivity of Choroidal Endothelial, Retinal Ganglion, and Retinal Pigment Epithelial Cells In Vitro to Proton Radiation

“…4,5 Proliferating endothelial cells present in CNV offer a potential target for radiation-based treatment. 6 Proton radiation, a form of particle radiation therapy, delivers a homogenous 3-dimensional dose to the target lesion with minimal damage to surrounding healthy tissues. 6 Unlike conventional radiation, ideally selected proton radiation dosage should destroy choroidal endothelial cells without damage to RPE cells or retinal ganglion cells.…”

“…6 Proton radiation, a form of particle radiation therapy, delivers a homogenous 3-dimensional dose to the target lesion with minimal damage to surrounding healthy tissues. 6 Unlike conventional radiation, ideally selected proton radiation dosage should destroy choroidal endothelial cells without damage to RPE cells or retinal ganglion cells. Recently, epimacular brachytherapy has been studied as a novel method to deliver radiation therapy directly to CNV.…”