Radiosurgical Treatment of Recurrent Esthesioneuroblastoma: Case Report

Abstract

Esthesioneuroblastoma (ENB) is a rare malignant neuroectodermal neoplasm originating from olfactory cells often with both of intracranial and extracranial growth. Since 1924 there are about 1200 reports of ENB worldwide. Treatment of ENB is still challenging caused by basal localization, infiltration of structures of anterior cranial fossa, very high local recurrence rate of 20-50% and possibility of distant metastases. In case of local recurrence is often applied a repeat resection or radiotherapy. However stereotactic radiosurgery is a non-invasive option. According to Gamma Knife Society database at the time of this report have been treated not more than 30 patients harboring ENB. In this case we report the use of Gamma Knife radiosurgery in management of recurrent ENB. Figure 1: Hematoxylin and eosin stained slides (x200) showing olfactory neuroblastoma with primitive neural cells forming epithelioid structures and pseudoresettes without glandular differentiation, subtle fibrillary matrix. Citation: Tokarev AS, Rak VA, Stepanov VN, Krylov VV (2018) Radiosurgical Treatment of Recurrent Esthesioneuroblastoma: Case Report. J Neurol Stroke 8(1): 00281.