Radionuclide and Angiographic Assessment of Pulmonary Perfusion After Fontan Procedure: Comparative Interim Outcomes

Yin, Zhihua; Wang, Huishan; Wang, Zengwei; Zhu, Huanzhang; Zhang, Renfu; Hou, Mingxiao; Fang, Minhua

doi:10.1016/j.athoracsur.2011.10.001

Cited by 11 publications

(8 citation statements)

References 17 publications

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“…One could reason that if the non-pulsatile flow in the pulmonary vasculature results in a smaller blood volume in the pulmonary arteries, then this could limit the diffusion capacity. Yin et al 31 have shown a redistribution of pulmonary blood flow after Fontan palliation, and this could also explain a reduced pulmonary diffusing capacity in these patients. Mettauer et al 32 described a restrictive lung pattern and reduced diffusing capacity in adults with chronic heart failure compared with healthy controls.…”

Section: Discussionmentioning

confidence: 92%

Impaired lung function in children and adolescents with Fontan circulation may improve after endurance training

et al. 2018

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Fontan patients have a restrictive lung pattern, reduced pulmonary diffusing capacity, and reduced maximal oxygen uptake compared with healthy controls. Endurance training may improve vital capacity in Fontan patients. The normal increase in pulmonary diffusing capacity with age and growth was reduced in Fontan patients, which is concerning. Apart from general health effects, exercise may improve lung function in young Fontan patients and should be encouraged.

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Section: Discussionmentioning

confidence: 92%

Impaired lung function in children and adolescents with Fontan circulation may improve after endurance training

et al. 2018

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“…Our data suggest that pulmonary flow splits in patients without PAVMs are relatively stable within 6 months. Yin and colleagues 26 reported a 5-year follow-up study on the pulmonary perfusion of 43 patients undergoing the Fontan. Their results showed that there are small differences (3% and 2%, respectively) in the pulmonary and IVC flow perfusion between the early postoperative and follow-up groups.…”

Section: Discussionmentioning

confidence: 99%

Flow simulations and validation for the first cohort of patients undergoing the Y-graft Fontan procedure

Yang

Chan

Reddy

et al. 2015

The Journal of Thoracic and Cardiovascular Surgery

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The credibility and accuracy of simulation-based predictions of postoperative hepatic flow distribution for the Fontan surgery have been validated by in vivo lung perfusion data. The performance of the Y-graft design is highly patient-specific. The anastomosis location is likely the most important factor influencing hepatic blood flow distribution. Although the development of thrombosis is multifactorial, the occurrence in 1 patient suggests that simulations should not solely consider the hepatic blood flow distribution but also aim to avoid low wall shear stress in the limbs.

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“…The application of pulmonary perfusion scintigraphy to evaluate lung function and the development of lung vessels has been documented in many studies. [ 8 , 16 – 18 ] It is widely available for clinical practice and fundamental research with unique advantages. First, lung perfusion scintigraphy was hardly affected by the tracer injection pressure.…”

Section: Discussionmentioning

confidence: 99%

“…Quantification was performed by delineating the regions of interest for the major lobes of the lung and obtaining the relative ratio of radioactivity counts in different regions. [ 8 ] Experienced physicians identified the lung segment with a perfusion abnormality, where the presence of a reduction in radioactivity counts or a perfusion defect was observed, and to quantitate the degree of the perfusion deficit further. A positive diagnosis was established if 1 or 2 lung segments concurrently exhibited perfusion abnormity.…”

Section: Methodsmentioning

confidence: 99%

Distribution of lung blood on modified bilateral Glenn shunt evaluated by Tc-99m-MAA lung perfusion scintigraphy

Luan²,

Wang

et al. 2016

Medicine

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The aim of the present study was to determine the distribution of lung blood in a modified bilateral Glenn procedure designed in our institute with lung perfusion scintigraphy. Sixteen consecutive patients who underwent modified bilateral Glenn operation from 2011 to 2014 were enrolled in the study. The control group consisted of 7 patients who underwent bidirectional Glenn shunt. Radionuclide lung perfusion scintigraphy was performed using Tc-99m-macro aggregated albumin (MAA) in all patients. For the patients in modified bilateral Glenn group, the time at which the radioactivity accumulation peaked did not differ significantly between the right and left lung field (t = 0.608, P = 0.554). The incidence of perfusion abnormality in each lung lobe also did not differ significantly (P = 0.426 by Fisher exact test). The radioactive counts were higher in the right lung than in the left lung, but the difference was not statistically significant (t = 1.502, P = 0.157). Radioactive perfusion in the lower lung field was significantly greater than that in the upper field (t = 4.368, P < 0.001). Compared with that in the bidirectional Glenn group, the ratio of radioactivity in the right lung to that in left lung was significantly lower in the modified bilateral Glenn group (t = 3.686, P = 0.002). Lung perfusion scintigraphy confirmed the benefit of the modified bilateral Glenn shunt with regard to more balanced blood perfusion in both lungs.

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Radionuclide and Angiographic Assessment of Pulmonary Perfusion After Fontan Procedure: Comparative Interim Outcomes

Cited by 11 publications

References 17 publications

Impaired lung function in children and adolescents with Fontan circulation may improve after endurance training

Impaired lung function in children and adolescents with Fontan circulation may improve after endurance training

Flow simulations and validation for the first cohort of patients undergoing the Y-graft Fontan procedure

Distribution of lung blood on modified bilateral Glenn shunt evaluated by Tc-99m-MAA lung perfusion scintigraphy

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