Radiology: pleural ultrasound

Cfn, Koegelenberg; Ct, Bolliger; Ah, Diacon

doi:10.1201/b13502-30

Cited by 7 publications

(8 citation statements)

References 14 publications

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“…2,18,19 The level of ADA can also be elevated in empyema, lymphoma, lung cancer, mesothelioma, leukemia, brucellosis, Q fever, rheumatoid arthritis, and systemic lupus erythematosis. 13,20,21 However, ADA >40 U/L in the context of a lymphocytic pleural effusion is tuberculosis-related in >95% of cases. 6,[22][23][24] There are 2 ADA isoenzymes, i.e., ADA1 and ADA2.…”

Section: Pleural Fluid: Adenosine Deaminasementioning

confidence: 97%

Pleural fluid characteristics of tuberculous pleural effusions

McGrath¹,

Warriner²,

Anderson³

2010

Heart & Lung

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Section: Pleural Fluid: Adenosine Deaminasementioning

confidence: 97%

Pleural fluid characteristics of tuberculous pleural effusions

McGrath¹,

Warriner²,

Anderson³

2010

Heart & Lung

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“…Positive rate of sputum acid-fast bacilli smear is merely 12% and the sensitivity of pleural fluid cultures is <40%. [ 2 , 4 , 5 ] Medical thoracoscopy delivers a good diagnostic advantage for tuberculous pleurisy, but it is an invasive technique associated with major (1.8%) and minor (7.3%) complications, [ 6 , 7 ] which may not be well accepted by certain patients especially the children and the elderly. [ 8 ] Thus such methods are either deficient in some manner or too invasive.…”

Section: Introductionmentioning

confidence: 99%

Accuracy of interleukin-27 assay for the diagnosis of tuberculous pleurisy

Li¹,

Zhu

Khan

et al. 2017

Medicine

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Background:The concentration of interleukin-27 (IL-27) in pleural effusions was found to be increased in tuberculous pleurisy and several studies have investigated the diagnostic value of IL-27 for tuberculous pleural effusions (TPEs), but the results varied a lot. We conducted the present study to comprehensively evaluate the diagnostic value of IL-27 for TPE.Methods:Primary diagnostic test studies of IL-27 for TPE was searched and identified from databases. The pooled sensitivity, specificity, positive likelihood ratio, negative likelihood ration, diagnostic odds ratio, and receiver operating characteristic curves (SROCs) were computed or pooled to summarize the overall test performance.Results:Nine studies with a total number of 1226 patients were identified in our research. The main pooled estimates were as follows: sensitivity 0.92 [95% confidence interval (CI), 0.90–0.95], specificity 0.90 (95% CI, 088–0.92), and area under the SROC 0.97. No evidence of publication bias was detected.Conclusion:Our research suggested the good diagnostic value of IL-27 for TPE and it could be used as a diagnostic biomarker.

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“…15,21,22 Fever, cough and shortness of breath were the most common symptoms occurring in 73% of the cases in agreement with other studies. 23 TPEs are typically unilateral (95%). 24 In one series of 254 patients with TB pleurisy, the effusions occupied between one-third and two-thirds of the hemithorax in 46%.…”

Section: Resultsmentioning

confidence: 99%

Study of the Clinnical Characteristics and Outcomes of Exudative Pleural Effusion: Improving Clinical Decision Making in Resource Limited Setting

Mishra

Bhatta

Koirala

et al. 2017

SAARC J. Tuber. Lung Dis. HIV/AIDS

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Introduction: In the background of resource limited setting like Nepal, we set out to identify if specific clinical characteristics and basic lab parameters would guide differentiation of Tuberculous from other causes of exudative pleural effusion.Methodology: Retrospective study of 109 consecutive patients with exudative pleural effusion.Results: Compared to Tubercular pleural effusions (41.3%), increased age, increased duration of symptom and increased pack years statistically favoured a diagnosis of Malignant pleural effusion(21.1%), whereas presence of fever, cough and increased pleural ADA levels favoured Tubercular pleural effusions. With regards to Parapneumonic effusions (26.6%), a shorter duration of symptom, smaller effusions, higher pleural Neutrophils, lower pleural lymphocyte neutrophil ratio and lower ADA favoured the diagnosis as compared to Tubercular pleural effusions.Conclusions: The appreciation of important clinical and pleural biochemical differences between Tubercular and other major causes of exudative pleural effusions aids in improved clinical decision making with minimal resources in resource limited settings like ours.SAARC J TUBER LUNG DIS HIV/AIDS, 2017; XIV(1), page: 33-39

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Radiology: pleural ultrasound

Cited by 7 publications

References 14 publications

Pleural fluid characteristics of tuberculous pleural effusions

Pleural fluid characteristics of tuberculous pleural effusions

Accuracy of interleukin-27 assay for the diagnosis of tuberculous pleurisy

Study of the Clinnical Characteristics and Outcomes of Exudative Pleural Effusion: Improving Clinical Decision Making in Resource Limited Setting

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