Radiological Manifestations of Neonatal Renal Vein Thrombosis on Follow-Up Examinations

Abstract

Renal atrophy involving all or part of one or both kidneys was found in 10 children with renal vein thrombosis who had been given conservative treatment. This appearance is nonspecific and can be found in any condition which disturbs the renal parenchyma. However, in a significant number of patients calcification produced a pathognomonic radiological pattern. Awareness of these late radiological manifestations may help in recognizing those cases in which renal vein thrombosis went unnoticed in the neonatal period and the patient is now found to have a perplexing radiological appearance.

Neonatal renal venous thrombosis in Germany between 1992 and 1994: epidemiology, treatment and outcome

“…This is in line with smaller series over the past 30 years [8,9,11,14,18] reporting an atrophy rate of 65% for supportive therapy and 68% for heparinization.…”

Neonatal Renal Venous Thrombosis: Clinical Outcomes and Prevalence of Prothrombotic Disorders

“…6,[21][22][23][24][25][26][27][28][29][30][31][32][33][34][35] The duration of followup ranged from 1 to 192 months. A large variation in the rates of glomerular and tubular defects, systemic hypertension, and abnormalities on renal imaging among studies has been noted, which could possibly be explained by the differences in the number of cases reported in each study and the duration of follow-up.…”

“…The sequelae of RVT reported in the literature include glomerular disease (3%-100%), tubular dysfunction (9%-47%), hypertension (9%-100%), and evidence of renal scarring or atrophy (27%-100%). 6,[21][22][23][24][25][26][27][28][29][30][31][32][33][34][35] The reported variation in the degree of morbidity suggests an underlying heterogeneity in the etiology of RVT that may lend itself to individualized management strategies to prevent long-term renal complications.…”

Prenatal Calcification of the Inferior Vena Cava and Renal Veins in a Normal Neonate

“…There are conflicting reports as to the prognosis of renal venous thrombosis. A series of reports [5,6,7,8] presented decreased renal function and subsequent atrophy of the involved kidney, while others [2,9,10] reported cases with preservation of normal kidney function. The management of renal venous thrombosis is also controversial [2].…”