Radiological cervical spine involvement in young adults with polyarticular juvenile idiopathic arthritis

Elhaï, Muriel; Wipff, Julien; Bazeli, R.; Freire, Véronique; Feydy, A.; Drapé, Jean‐Luc; Quartier, Pierre; Kahan, André; Job-Deslandre, C

doi:10.1093/rheumatology/kes054

Cited by 47 publications

(33 citation statements)

References 26 publications

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“…Inflammation of the spine and coxofemoral joints is an indicator of more serious forms of the disease. 19,36,37 In our study, spreading to the cervical spine and coxofemoral joints arthritis were only found in children with detectable IL-17A values in the active phase of JIA. Therefore, children with detectable IL-17A levels should be closely monitored, and such results imply that, on the basis of IL-17A values in the initial phase of JIA, it may be possible to select patients at a higher risk from a worse functional outcome.…”

Section: Discussioncontrasting

confidence: 45%

Interleukin-17A Levels Increase in Serum of Children With Juvenile Idiopathic Arthritis

et al. 2017

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Objectives: This study aims to determine the serum levels of interleukin-17A (IL-17A) in children with juvenile idiopathic arthritis (JIA) and analyze the correlation between IL-17A values and disease activity, certain clinical features, and laboratory markers of inflammation. Patients and methods:The study included 30 children (7 boys, 23 girls; mean age 8.8±5.3 years; range 1 to 18 years), who had been diagnosed with JIA (18 children were diagnosed during the study period and 12 children were diagnosed before the start of the study) and had active disease during the study period. Control group included 30 healthy, age-and sex-matched children (9 boys, 21 girls; mean age 8.3±4.8 years; range 1 to 18 years). The enzyme-linked immunosorbent assay was used to assess the serum IL-17A levels of children with JIA in the active phase of the disease and control group. Clinical and laboratory features of the disease were evaluated for the children with JIA. Results: Serum levels of IL-17A in children with JIA were significantly higher in comparison to control group. In children with JIA who were prospectively monitored, statistically significantly decreased IL-17A level was recorded in the inactive phase of the disease. The incidence of arthritis of coxofemoral joints was significantly more common, and the mean levels of erythrocyte sedimentation rate and C-reactive protein were significantly higher in the group of children with JIA with detectable levels of IL-17A. Children with JIA and detectable levels of IL-17A had significantly higher values of Juvenile Arthritis Disease Activity Score-27 in comparison to children with JIA and non-detectable IL-17A. Conclusion: Assessment of serum IL-17A levels in early phases of JIA gives an opportunity for early detection of children that have higher risk for worse functional outcome.

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Section: Discussioncontrasting

confidence: 45%

Interleukin-17A Levels Increase in Serum of Children With Juvenile Idiopathic Arthritis

et al. 2017

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“…The indolent process of leucocyte infiltration into the synovium and proliferation of the synovial tissue lead to a subacute type of inflammation, which may justify that pain is not the most conspicuous feature of clinical presentation of JIA, that may pain be missed, particularly in oJIA [13]. This may justify the frequent absence of neck pain in JIA, regardless of CSI, and its worse prognosis [3].…”

Section: Case Seriesmentioning

confidence: 99%

“…Pain is frequently absent, even in cervical arthritis [3,14]. In the 6 cases described in the literature, at least 3 patients had no pain, at least transitorily, during a few weeks.…”

Section: Case Seriesmentioning

confidence: 99%

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Cervical arthritis as presentation of oligoarticular juvenile idiopathic arthritis

Coutinho¹,

Estanqueiro²,

Alves³

et al. 2017

Ann Paediatr Rheum

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“…Любой сустав может являться мишенью ювениль-ного артрита, однако наиболее часто поражаются крупные и средние суставы, а именно коленные, голеностопные, лучезапястные, локтевые, тазобед-ренные, реже -мелкие суставы кистей и стоп. При тяжелых вариантах течения заболевания во-влекаются «синовиальные суставы» шейного отдела позвоночника и височно-нижнечелюстной сустав с развитием деформирующего артроза [12,15,19].…”

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Juvenile Arthritis: Clinical Manifestations and Differential Diagnosis and Differential Diagnosis

Kozhevnikov

Николаевич²,

Поздеева

et al. 2014

Pediatr Traum Orthop Reconstr Surg

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Резюме. Одной из актуальных проблем современной ревматологии и ортопедии является диагностика и лечение воспалительных заболеваний суставов у детей. Среди многообразия хронических воспалительных артропатий в детском и подростковом возрасте наиболее распространено такое заболевание, как ювениль-ный артрит (ЮА). Однако диагностика его до сих пор вызывает затруднения, нередки диагностические ошибки. В статье приведены современные представления о ювенильном артрите, подробно изложены варианты течения, клиническая и инструментальная картина данного заболевания. Рассмотрены вопросы дифференциальной диагностики хронического синовита.Ключевые слова: ювенильный артрит, хронический синовит, моноартрит, диагностика.

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Radiological cervical spine involvement in young adults with polyarticular juvenile idiopathic arthritis

Cited by 47 publications

References 26 publications

Interleukin-17A Levels Increase in Serum of Children With Juvenile Idiopathic Arthritis

Interleukin-17A Levels Increase in Serum of Children With Juvenile Idiopathic Arthritis

Cervical arthritis as presentation of oligoarticular juvenile idiopathic arthritis

Juvenile Arthritis: Clinical Manifestations and Differential Diagnosis and Differential Diagnosis

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