Radiological bone changes and angiographic findings in leprosy

“…Florid cases show total joint destruction and dislocation, usually with sclerosis, occasionally atrophy, of the bone ends, often with residual loose fragments. Chronic soft tissue inflammation may cause progressive absorption of metatarsals and phalanges leading eventually to "pencil sharpening" of the residual bone ends and shrinkage of the soft tissues as in the neuroarthropathy of leprosy (Paterson, 1955).…”

Section: Neuroarthropathy In Charcot-marie-tooth Diseasementioning

confidence: 99%

Neuroarthropathy in Charcot-Marie-Tooth disease.

Bruckner¹,

Kendall²

1969

Annals of the Rheumatic Diseases

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“…In childhood the commonest cause is meningomyelocele (Carr, 1956). More rarely, it has been noted in congenital insensitivity to pain (Mooney and Mankin, 1966), familial dysautonomia (Brunt, 1967), hereditary sensory neuropathy Uohnson and Spalding, 1964), peripheral nerve injury (Floyd et al, 1959), the neuropathy of leprosy (Paterson, 1955), pernicious anaemia myelopathy (Halonen and Jfirvinen, 1948), multiple sclerosis (Rosenthal, 1965), and spinal-cord injury (Kettunen, 1957).…”

Section: Medical Memorandamentioning

confidence: 99%

Double charcot's disease.

Bruckner¹

1968

BMJ

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A particular difference from European communities is that we have the distinct impression that stress is not an important factor here-we rarely see the hypertensive with "executive stress," so frequently encountered elsewhere. It has always been difficult -to explain the apparent hypotensive effect of propranolol on pharmacological grounds, and it could be that the mild tranquillizing effect attributed to it is responsible. Such an effect might have little action on the blood pressures of Jamaicans; it is noteworthy that we scarcely ever use phenobarbitone as a hypotensive here.We do not think that there is any justification for using propranolol as a hypotensive agent at the present time, but there is an obvious and immediate need for a properly controlled trial in European patients, preferably for a longer period than that of our own trial. SUmmUEighteen hypertensive Jamaicans underwent a double-blind cross-over trial of propranolol in order to prove or disprove the assertion that the drug is a relatively potent hypotensive agent.Though the dosage used was high there was no significant difference in effect between the drug and an inert placebo. It is suggested that this may have been so because the " tranquillizing " effect of the drug is unlikely to be of value in Jamaican hypertensive patients.We stress that our conclusions do not necessarily apply to European patients, in whom a properly controlled trial is urgently needed, preferably for longer periods of therapy to exclude any possible "carry-over" effect.Propranolol in high dosage is remarkably free front sideeffects when given to carefully selected patients.

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Radiological bone changes and angiographic findings in leprosy

Cited by 31 publications

References 20 publications

Trial of a Vasodilator on Trophic Ulcers

Trial of a Vasodilator on Trophic Ulcers

Neuroarthropathy in Charcot-Marie-Tooth disease.

Double charcot's disease.

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