Radiologic Characteristics of Surgically Resected Non-Small Cell Lung Cancer With ALK Rearrangement or EGFR Mutations

Kim, Tae Jung; Lee, Choon Taek; Jheon, Sang Hoon; Park, Jeong‐Soo; Chung, Jin Haeng

doi:10.1016/j.athoracsur.2015.07.062

Cited by 49 publications

(47 citation statements)

References 32 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Previous studies have attempted to assess CT characteristics associated with ALK -rearranged NSCLC. These studies revealed that ALK -rearranged tumors were more likely to be solid tumors without GGO and tumors with lower TDR [6, 14, 16]. Our results were consistent with these previous reports.…”

Section: Discussionsupporting

confidence: 93%

“…[16] found NSCLC with ALK rearrangements had lobulated margins, Zhou et al . [14] found lobulated margins were less frequently in lung adenocarcinomas with ALK rearrangements than in those with EGFR mutations.…”

Section: Discussionmentioning

confidence: 99%

“…To date there have been few published studies assessing the association between CT imaging features and ALK rearrangements among NSCLC patients [6, 10-16], and the results were still somewhat conflicting. Most of these studies included advanced tumors whose histology and mutational status were obtained from biopsy samples of primary or metastatic sites that may not accurately reflect the pathological and molecular characteristics of the tumor [10-15].…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Clinical and CT characteristics of surgically resected lung adenocarcinomas harboring ALK rearrangements or EGFR mutations

Wang

Schabath

Liu

et al. 2016

European Journal of Radiology

View full text Add to dashboard Cite

Purpose To determine if clinical and CT characteristics of surgically resected lung adenocarcinomas can distinguish those harboring ALK rearrangements from EGFR mutations. Materials and Methods Patients who had surgical resection and histologically confirmed lung adenocarcinoma were enrolled, including 41 patients with ALK rearrangements and 66 patients with EGFR mutations. Eighteen categorical and six quantitative CT characteristics were used to evaluate the tumors. Differences in clinical and CT characteristics between the two groups were investigated. Results Age (P = 0.003), histological subtypes (P < 0.001), pathological stage (P = 0.007), and five CT characteristics, including size (P < 0.001), GGO (P = 0.001), bubble-like lucency (P = 0.048), lymphadenopathy (P = 0.001), and tumor shadow disappearance rate (P = 0.005) were significantly different between patients harboring ALK rearrangements compared to patients with EGFR mutations. When we compared histologic components, a solid pattern was more common (P = 0.009) in tumors with ALK rearrangements, and lepidic and acinar patterns were more common (P < 0.001 and P = 0.040, respectively) in those with EGFR mutations. Backward elimination analyses revealed that age (OR = 0.93; 95% CI 0.89 – 0.98), GGO (OR = 0.14; 95% CI 0.03 – 0.67), and lymphadenopathy (OR = 4.15; 95% CI 1.49 – 11.60) were significantly associated with ALK rearrangement status. Conclusion Our analyses revealed that clinical and CT characteristics of lung adenocarcinomas harboring ALK rearrangements were significantly different, compared with those with EGFR mutations. These differences may be related to the molecular pathology of these diseases.

show abstract

Section: Discussionsupporting

confidence: 93%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Clinical and CT characteristics of surgically resected lung adenocarcinomas harboring ALK rearrangements or EGFR mutations

Wang

Schabath

Liu

et al. 2016

European Journal of Radiology

View full text Add to dashboard Cite

show abstract

“…However, another study discovered ALK rearrangement positive lung adenocarcinomas were more likely to be large and with thoracic lymphadenopathy (15). A nearly research suggests that patents with ALK rearrangement is younger, and characterized by lobulated margin and solid lesion compared with EGFR mutant and wide type cohorts in surgically resected NSCLCs (16). These conclusions were mostly studied in early stage NSCLCs, and may remain some uncertainties.…”

Section: Introductionmentioning

confidence: 99%

“…Although a lot of studies found ALK rearrangement was highly occurred in younger, female and never smoked adenocarcinomas, it was overlapped with EGFR mutated patients on clinical profiles (10)(11)(12). Fortunately, some radiologic characteristics of ALK rearrangement were detected (13)(14)(15)(16). Nakada et al (14) reported that ALK rearrangement lesions were smaller and had a low tumor disappearance rate than EGFR mutated lesions on high-resolution computed tomography (HRCT).…”

Section: Introductionmentioning

confidence: 99%

Comparison of clinical and radiological characteristics between anaplastic lymphoma kinase rearrangement and epidermal growth factor receptor mutation in treatment naïve advanced lung adenocarcinoma

Miao

Zhu

et al. 2017

J. Thorac. Dis.

View full text Add to dashboard Cite

Background: Gene analysis could not be performed in all patients, especially in advanced non-small cell lung cancer (NSCLC). We aimed to find some clinical futures and CT or FDG-PET characteristics, which could be combined to help distinguish anaplastic lymphoma kinase (ALK) rearrangement form epidermal growth factor receptor (EGFR) mutations in treatment naïve advanced lung adenocarcinoma of Chinese patients. Methods:We retrospectively reviewed clinical and radiological characteristics of 145 patients with treatment naïve advanced lung adenocarcinoma. The one-way ANOVA, the Mann-Whitney test, chi-square test and logistic regression were used for comparison between patients with ALK rearrangement and those with EGFR mutation.Results: Among 145 patients with advanced lung adenocarcinoma, only six patients had both ALK rearrangement and EGFR mutation, the sample size was too small to analysis. Univariate analysis revealed that patients with ALK rearrangement were younger (P=0.001) and with lower serum carcinoembryonic antigen (CEA) level (P=0.008) than those with EGFR mutation. More of tumors with ALK rearrangement were well defined (P=0.023) and have bubble lucency (P=0.026) compared with those with EGFR mutation (P=0.026). Lymphadenopathy was seen more frequently in patients with ALK rearrangement (P=0.167). Twenty-six patients received FDG-PET/CT, among this population, lesion standardized uptake values (SUV)>6.95 and lymph nodes SUV max >6.25 were more often seen in ALK rearrangement group (P=0.011, both).In multivariate analysis, patients younger than 50 years (RR =9.878, 95% CI: 2.318-42.090, P=0.002), with lower CEA level than 4.95 μg/L (RR =8.166, 95% CI: 1.085-31.983, P=0.003) and without brain metastasis (RR =7.304, 95% CI: 1.099-48.558, P=0.040) were more likely to be ALK rearrangement than EGFR mutation. Tumor diameter less than 36 mm were prone to be EGFR mutation (RR =0.078, 95% CI: 0.017-0.356, P=0.001).Conclusions: Treatment naïve advanced lung adenocarcinomas with ALK rearrangement were more likely to have younger age, lower serum CEA level, larger tumor volume, well defined tumor border, and non-brain metastasis than those with EGFR mutation. Bubble lucency and higher FDG uptake of lesion and lymph nodes may help distinguish ALK rearrangement from EGFR mutation in the absence of genetic analysis.

show abstract

Correlation between combining 18F–FDG PET/CT metabolic parameters and other clinical features and ALK or ROS1 fusion in patients with non-small-cell lung cancer

Ruan

Liu

Wang

et al. 2020

Eur J Nucl Med Mol Imaging

View full text Add to dashboard Cite

Radiologic Characteristics of Surgically Resected Non-Small Cell Lung Cancer With ALK Rearrangement or EGFR Mutations

Cited by 49 publications

References 32 publications

Clinical and CT characteristics of surgically resected lung adenocarcinomas harboring ALK rearrangements or EGFR mutations

Clinical and CT characteristics of surgically resected lung adenocarcinomas harboring ALK rearrangements or EGFR mutations

Comparison of clinical and radiological characteristics between anaplastic lymphoma kinase rearrangement and epidermal growth factor receptor mutation in treatment naïve advanced lung adenocarcinoma

Correlation between combining 18F–FDG PET/CT metabolic parameters and other clinical features and ALK or ROS1 fusion in patients with non-small-cell lung cancer

Contact Info

Product

Resources

About