Radiolabeled Nanoparticles for Molecular Imaging

A study on drug delivery tracing with radiolabeled mesoporous hydroxyapatite nanoparticles conjugated with 2DG/DOX for breast tumor cells

“…Therefore, it suggests an increased uptake capability in human and mice breast cancer cells. The obtained results are in agreement with the previous studies on the radiolabeling, uptaking and also biodistribution of [ Tc]-nano-2DG-DOX could confirm the claim that the radiolabeled nanoparticle is an attractive candidate in cancer therapy, owing to its great potential for radioisotopic imaging study [4,18,28,29].…”

Translational radionanomedicine: a clinical perspective

“…Encapsulation of radiotracer has been classically studied, particularly in liposomes, using gamma-emitters of 99m Tc or 111 In combined with their chelators (46)(47)(48)(49) or using positron-emitters of 124 I and 18 F attached to lipid molecules for membrane labeling (50,51). Extrinsic radiolabeling on the surfaces of nanomaterials can be used, ranging from inorganic nanomaterials such as gold nanoparticles or quantum dots to organic nanoparticles including liposomes (42,52). Extrinsic radiolabeling is commonly used for nanoparticles ranged from inorganic to organic nanoparticles.…”

Nanomedicine—Nanoparticles in Cancer Imaging and Therapy

“…For example, magnetic NPs (i.e. IONPs, gold NPs, SWNT NPs) have thermoablative properties, which can lead to carcinoma destruction when localized heat, from sources such as infrared lamps, ultrasound or lasers, is applied [77]. Unfortunately, it is difficult to contain the heat in a localized area; however, the problem can be avoided with NPs that are designed to absorb NIR light, such as that emitted from laser irradiation.…”

“…To this point, QDs, IONPs, single-walled carbon nanotube (SWNT) and gold NPs, have all been radiolabeled with 64 Cu ligands for PET/MRI or PET/NIRF imaging [77]. Combining two different methods of imaging permits the same molecular target to be imaged in order to obtain additional information, such as anatomical and molecular information, which would not normally be achieved by a single modality.…”

“…Combining two different methods of imaging permits the same molecular target to be imaged in order to obtain additional information, such as anatomical and molecular information, which would not normally be achieved by a single modality. Thus, the combination of modalities used to study the same target enhances diagnostic accuracy due to improved sensitivity and greater resolution [77].…”