Radioimmunoassay of serum myoglobin in acute myocardial infarction

Jutzy, Roy V.; Nevatt, George W.; Palmer, Fred J.; Nelson, Jerald C.

doi:10.1016/0002-9149(75)90691-8

Cited by 20 publications

(4 citation statements)

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“…The complement-fixation assay employed by Kagen et al was sensitive enough for detection of 0.03 gg of myoglobin, but these workers were unable to demonstrate myoglobinemia in 42 of 48 patients without myocardial infarction. Recently, another group of investigators has described in preliminary form an immunoassay for myoglobin (12); their results in patients with myocardial infarction thus far appear similar to those reported herein by us.…”

Section: Discussionsupporting

confidence: 85%

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Radioimmunoassay of myoglobin in human serum. Results in patients with acute myocardial infarction.

Stone¹,

Willerson²,

Gómez-Sánchez³

et al. 1975

J. Clin. Invest.

172

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A B S T R A C T A radioimmunoassay has been developed for the measurement of serum myoglobin in order to evaluate the time-course and frequency of myoglobinemia in patients with acute myocardial infarction. The method can detect as little as 0.5 ng of myoglobin and is not affected by hemolysis or storage of serum at -200C. Myoglobin was detected in all of 92 sera from normal adults and ranged between 6 and 85 ng/ml. Levels were markedly elevated in sera from 18 of 20 patients with acute myocardial infarction when samples were obtained within 12 h after hospital admission, the mean concentration being 380±53 ng/ml. When the initial sample was drawn between 12 and 24 h after admission in another group of 20 patients with acute myocardial infarcts, the mean serum myoglobin concentration was 195±47 ng/ml, and 11 of these individuals had normal levels. Serial determinations performed on nine patients with acute infarction demonstrated that maximum myoglobin levels occurred within the first 8-12 h after admission and fell rapidly toward normal thereafter. The serum concentration of myoglobin in 21 additional patients admitted with chest pain but without acute myocardial infarction was 41±6 ng/ml. Radioimmunoassay of serum myoglobin appears to be a useful and sensitive test for the early detection of myocardial infarction.

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Section: Discussionsupporting

confidence: 85%

“…Received for publication 9 May 1975 and in revised form 12 August 1975. establish the diagnosis definitely. Therefore, efforts have been made to find more sensitive and possibly more specific tests which might aid in documenting the presence and extent of myocardial necrosis (1).…”

Section: Introductionmentioning

confidence: 99%

Radioimmunoassay of myoglobin in human serum. Results in patients with acute myocardial infarction.

Stone¹,

Willerson²,

Gómez-Sánchez³

et al. 1975

J. Clin. Invest.

172

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“…Substantial evidence suggests that damage to the cardiac muscle mass might result in release of myoglobin as well as various intracellular enzymes into the circulation. Thus, other investigators have reported that myoglobin is transiently detectable in urine or serum of some patients with acute myocardial infarction (Saranchak and Bernstein, 1974;Kagen et al, 1975;Jutzy et al, 1975;Kessler et al, 1975). For these reasons, we have recently developed a competitive binding radioimmunoassay 'This study was supported in part by NIH Ischemic Heart Disease Specialized Center of Research (SCOR) Grant HL-17669, and by American Heart Association Grant 75-819.…”

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confidence: 99%

Serum myoglobin level as diagnostic test in patients with acute myocardial infarction.

Stone¹,

Waterman²,

Harimoto³

et al. 1977

Heart

122

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Serum myoglobin levels were measured in normal subjects and patients by means of a newly developed radioimmunoassay. Myoglobin was identified in all of 135 sera from normal adults and ranged between 6 and 85 ng/ml (mean +/- SE 31 +/- 1.3). Raised myoglobin levels were present in 62 of 64 patients with documented acute myocardial infarction, the mean serum concentration being 528 +/- 76 ng/ml. Serial determinations in 46 patients with acute infarct showed that maximum values usually occurred within 4 hours after admission. In 19 of 42 cases, raised myoglobin levels preceded the rise in creatine kinase (CK) values; in the remaining patients, both serum myoglobin and creatine kinase were increased on admission. Only 2 of an additional 44 patients admitted with chest pain but without subsequent electrocardiographic, enzyme, or technetium-99m stannous pyrophosphate myocardial scintigraphic evidence of acute myocardial infarction had raised myoglobin levels; the mean value for this group was within the normal range (44 +/- 6 ng/ml). Serum myoglobin values also were normal in patients with congestive heart failure without acute myocardial infarction, and in patients after moderate exercise and cardiac catheterisation. Trasient myoglobinaemia appears to be one of the earliest laboratory abnormalities occurring in acute myocardial infarction and, therefore, should prove useful as a diagnostic aid in patients.

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“…Substantial evidence suggests that damage to the cardiac muscle mass might result in release of myoglobin as well as various intracellular enzymes into the circulation. Thus, other investigators have reported that myoglobin is transiently detectable in urine or serum of some patients with acute myocardial infarction (Saranchak and Bernstein, 1974;Kagen et al, 1975;Jutzy et al, 1975;Kessler et al, 1975). For these reasons, we have recently developed a competitive binding radioimmunoassay for myoglobin which is more sensitive than previously described methods (Stone et al, 1975).…”

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confidence: 97%

Patients With Acute Myocardial Infarction

2019

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Radioimmunoassay of serum myoglobin in acute myocardial infarction

Cited by 20 publications

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Radioimmunoassay of myoglobin in human serum. Results in patients with acute myocardial infarction.

Radioimmunoassay of myoglobin in human serum. Results in patients with acute myocardial infarction.

Serum myoglobin level as diagnostic test in patients with acute myocardial infarction.

Patients With Acute Myocardial Infarction

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