Basic Radiation Oncology 2010
DOI: 10.1007/978-3-642-11666-7_2
View full text |Buy / Rent full text
|
Sign up to set email alerts
|
Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
1
1
1
1

Citation Types

0
7
0

Year Published

2012
2012
2022
2022

Publication Types

Select...
4

Relationship

0
4

Authors

Journals

citations
Cited by 6 publications
references
References 35 publications
0
7
0
Order By: Relevance
“…HEF was introduced in Equation 4 in the similar way that the oxygen enhancement ratio (OER) was introduced for acute hypoxia [ 17 , 18 ]. Equation 5 was designed to give HEF = 1 for patients having a Hb level of 13 g/dL, which is a normal value.…”
Section: Methodsmentioning
confidence: 99%
“…HEF was introduced in Equation 4 in the similar way that the oxygen enhancement ratio (OER) was introduced for acute hypoxia [ 17 , 18 ]. Equation 5 was designed to give HEF = 1 for patients having a Hb level of 13 g/dL, which is a normal value.…”
Section: Methodsmentioning
confidence: 99%
“…15 Radiosensitivity of a cell can be 4-fold greater during the mitotic phase than during the interphase. 16 Thus, it is possible that more rapidly dividing and highly metabolic tumors would be more responsive to radiotherapy and do worse.…”
Section: Discussionmentioning
confidence: 99%
“…Hypoxia presents in almost all solid tumors and is both an important factor driving tumor progression and a leading obstacle to therapeutic efforts. Oxygen insufficiency significantly inhibits the generation of appreciable amounts of ROS, leading to a failure to destroy tumor tissues. Meanwhile, previous studies have reported that PDT-mediated oxygen consumption can further increase hypoxic degree, leading to additional adverse consequences such as recurrence or metastasis. Clinically, researchers have found that hypoxic tumor cells cannot be effectively killed by radiotherapy due to the fact that normal RT is also obviously affected by the amount of O 2 to ensure maximum cell death, namely, the hypoxia due to the consumption of O 2 decreases cellular radiosensitivity and thus fails to “fix” DNA damage during RT. , Feasible strategies to overcome these limitations include delivery of oxygen to tumors, development of oxygen-generating manganese dioxide nanoparticles, or incorporation of antiangiogenesis therapy . Recently, with rapid developments in X-PDT, the issue of hypoxia has also been discussed in this field, with strategies including employment of X-ray excited type-I PDT, NO generation, and oncolytic bacterium therapy proposed to conquer tumor hypoxia and achieve low-dose X-PDT.…”
Section: Strategies To Achieve Low Radiation Dose In X-pdtmentioning
confidence: 99%
“…132−134 Clinically, researchers have found that hypoxic tumor cells cannot be effectively killed by radiotherapy due to the fact that normal RT is also obviously affected by the amount of O 2 to ensure maximum cell death, namely, the hypoxia due to the consumption of O 2 decreases cellular radiosensitivity and thus fails to "fix" DNA damage during RT. 81,135 Feasible strategies to overcome these limitations include delivery of oxygen to tumors, 87 development of oxygengenerating manganese dioxide nanoparticles, 136 or incorporation of antiangiogenesis therapy. 137 Recently, with rapid developments in X-PDT, the issue of hypoxia has also been discussed in this field, with strategies including employment of X-ray excited type-I PDT, NO generation, and oncolytic bacterium therapy proposed to conquer tumor hypoxia and achieve low-dose X-PDT.…”
Section: Strategies To Overcome Local Hypoxic Tumor Microenvironmentmentioning
confidence: 99%