Radio-synthesized polyacrylamide hydrogels for proteins release

Ferraz, Caroline C.; Varca, Gustavo H.C.; Lopes, Patrícia Santos; Mathor, Mônica Beatriz; Lugão, Ademar B.

doi:10.1016/j.radphyschem.2013.05.053

Cited by 8 publications

(4 citation statements)

References 16 publications

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“…This process was also organic solvent-free, reducing the risk of payload modification and residual toxic solvents [106]. To date, several labs have managed to produce various sterilized hydrogel formulations [106,107].…”

Section: Hydrogels For Sustained Delivery Of Anti-vegfmentioning

confidence: 99%

Use of biomaterials for sustained delivery of anti-VEGF to treat retinal diseases

Seah

Zhao

Lin

et al. 2020

Eye

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Anti-vascular endothelial growth factors (anti-VEGF) have become the most common treatment modality for many retinal diseases. These include neovascular age-related macular degeneration (n-AMD), proliferative diabetic retinopathy (PDR) and retinal vein occlusions (RVO). However, these drugs are administered via intravitreal injections that are associated with sight-threatening complications. The most feared of these complications is endophthalmitis, a severe infection of the eye with extremely poor visual outcomes. Patients with retinal diseases typically have to undergo multiple injections before achieving the desired therapeutic effect. Each injection incurs the risk of the sight-threatening complications. As such, there has been great interest in developing sustained delivery platforms for anti-VEGF agents to the posterior segment of the eye. In recent years, there have been various strategies that have been conceptualised. These include non-biodegradable implants, nano-formulations and hydrogels. In this review, the barriers of drug delivery to the posterior segment of the eye will be explained. The characteristics of an ideal sustained delivery platform will then be discussed. Finally, the current available strategies will be analysed with the above-mentioned characteristics in mind to determine the advantages and disadvantages of each sustained drug delivery modality. Through the above, this review attempts to provide an overview of the sustained delivery platforms in their various phases of development.These authors contributed equally: Ivan Seah Yu Jun, Zhao Xin Xin 1234567890();,:1234567890();,:

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Section: Hydrogels For Sustained Delivery Of Anti-vegfmentioning

confidence: 99%

Use of biomaterials for sustained delivery of anti-VEGF to treat retinal diseases

Seah

Zhao

Lin

et al. 2020

Eye

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“…Not only would it produce a final sterile hydrogel but would also remove the need for a polymerization initiator. Several labs have produced sterilized polymer via SH, GI, and ethylene oxide (Ji and Shi, 2012, Ferraz et al, 2014.…”

Section: Manufacturingmentioning

confidence: 99%

Hydrogel-based ocular drug delivery systems: Emerging fabrication strategies, applications, and bench-to-bedside manufacturing considerations

Cooper

Yang

2019

Journal of Controlled Release

117

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The physiological barriers of the eye pose challenges to the delivery of the array of therapeutics for the effective medication of ocular diseases as well as patient compliance. While the innovations in drug encapsulation and release mechanisms, biocompatibility, and treatment duration have become highly sophisticated, the challenge of widespread application of hydrogel formulations in the clinic is still apparent. This article reviews the latest hydrogel formulations and their associated chemistries for use in ocular therapies, spanning from external anterior to internal posterior regions of the eye in order to evaluate the state of recent research. This article discusses the utility of hydrogels in soft contact lens, wound dressings, intraocular lens, vitreous substitutes, vitreous drug release hydrogels, and cell-based therapies for regeneration. Additional focus is placed on the pre-formulation, formulation, and manufacturing considerations of the hydrogels based on individual components (polymer chains, linkers, and therapeutics), final hydrogel product, and required preparations for clinical/commercial applications, respectively.

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“…The researchers observed some burst behavior due to the deposition of the enzyme on the surface of the hydrogel, but not all of the papain content was released within the 50 h of the experiment. It is clear that the structure of the 3D matrix influences the protein release behavior [36].…”

Section: Semi-solid Formulation Stability Assessmentmentioning

confidence: 99%

Semi-Solid Pharmaceutical Formulations for the Delivery of Papain Nanoparticles

et al. 2020

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Papain is a therapeutic enzyme with restricted applications due to associated allergenic reactions. Papain nanoparticles have shown to be safe for biomedical use, although a method for proper drug loading and release remains to be developed. Thus, the objective of this work was to develop and assess the stability of papain nanoparticles in a prototype semi-solid formulation suitable for dermatological or topical administrations. Papain nanoparticles of 7.0 ± 0.1 nm were synthesized and loaded into carboxymethylcellulose- and poly(vinyl alcohol)-based gels. The formulations were then assayed for preliminary stability, enzyme activity, cytotoxicity studies, and characterized according to their microstructures and protein distribution. The formulations were suitable for papain nanoparticle loading and provided a stable environment for the nanoparticles. The enzyme distribution along the gel matrix was homogeneous for all the formulations, and the proteolytic activity was preserved after the gel preparation. Both gels presented a slow release of the papain nanoparticles for four days. Cell viability assays revealed no potential cytotoxicity, and the presence of the nanoparticles did not alter the microstructure of the gel. The developed systems presented a potential for biomedical applications, either as drug delivery systems for papain nanoparticles and/or its complexes.

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Radio-synthesized polyacrylamide hydrogels for proteins release

Cited by 8 publications

References 16 publications

Use of biomaterials for sustained delivery of anti-VEGF to treat retinal diseases

Use of biomaterials for sustained delivery of anti-VEGF to treat retinal diseases

Hydrogel-based ocular drug delivery systems: Emerging fabrication strategies, applications, and bench-to-bedside manufacturing considerations

Semi-Solid Pharmaceutical Formulations for the Delivery of Papain Nanoparticles

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