Radio- and nano-chemistry of aqueous Ga(<scp>iii</scp>) ions anchored onto graphene oxide-modified complexes

Sarpaki, Sophia; Cortezon‐Tamarit, Fernando; Aguiar, Sara R. M. M. de; Exner, Rüdiger M.; Divall, D.; Arrowsmith, Rory L.; Ge, Haobo; Palomares, F. J.; Carroll, Laurence; Calatayud, David G.; Paisey, Stephen J.; Aboagye, Eric O.; Pascu, Sofia I.

doi:10.1039/c9nr10145d

Cited by 11 publications

(23 citation statements)

References 33 publications

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“…This interaction was shown to be highly favourable with RCYs and stability in human serum (up to 2 h) both 495%. 551 The authors also reported a novel bis(semithiocarbazonate) 68 Ga 3+ complex (Fig. 30C) capable of radiolabelling GO.…”

Section: Radiolabelling Of Organic Nanomaterialsmentioning

confidence: 96%

“…30C) capable of radiolabelling GO. Radiolabelling with this complex allowed high RCY 4 95% and high serum stability 495% up to 2 h. 551 Characterisation using energydispersive X-ray spectroscopy (EDX) mapping the non-radioactive gallium complex suggested that the complex was incorporated non-covalently within the GO layers (Fig. 30C).…”

Section: Radiolabelling Of Organic Nanomaterialsmentioning

confidence: 99%

“…(top) and a schematic showing the proposed incorporation of the68 Ga 3+ complex into the GO sheets (bottom). Reported by Sarpaki et al551…”

mentioning

confidence: 91%

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Radiolabelling of nanomaterials for medical imaging and therapy

2021

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Section: Radiolabelling Of Organic Nanomaterialsmentioning

confidence: 96%

Section: Radiolabelling Of Organic Nanomaterialsmentioning

confidence: 99%

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Radiolabelling of nanomaterials for medical imaging and therapy

2021

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“…Subsequent hydrazinolysis of 2a – c yielded the desired thiosemicarbazides ( 3a – c ). The synthesis of the acenaphthenequinone-based mono(thiosemicarbazone) ligands was achieved following a modification of the previously described methodology, 20 whereby the suspension of acenaphthenequinone and the thiosemicarbazide were reacted in acetic acid under microwave irradiation under a variety of conditions, with the most promising reaction being carried out for 20 min at 90 °C.…”

Section: Resultsmentioning

confidence: 99%

“… 19 There is significant interest in the chemistry of bis(thiosemicarbazone) ligands featuring different radioactive metals as theranostic agents, and their potential as imaging agents for hypoxia has been investigated. 20 The recent developments in the commercial availability of Gallium-68 from 68 Ge/ 68 Ga generators provide a reliable source of this positron-emitting radionuclide. The advantageous decay properties of Gallium-68 ( E max = 1.9 MeV, β + 90%) coupled with a half-life of 68 min make this radionuclide attractive for imaging applications based on small molecules and/or biomolecules with relatively fast uptake and clearance rates.…”

Section: Introductionmentioning

confidence: 99%

Functional, Aromatic, and Fluorinated Monothiosemicarbazones: Investigations into Their Structures and Activity toward the Gallium-68 Incorporation by Microwave Irradiation

et al. 2022

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We report on the synthesis and spectroscopic characterization of a new series of coordinating monothiosemicarbazones incorporating aromatic backbones, featuring O/N/S donor centers monosubstituted with different aliphatic, aromatic, fluorinated, and amine-functionalized groups at their N centers. Their ability to bind metal ions such as Zn(II) and Ga(III) was explored, and the formation of two different coordination isomers of the Zn(II) complex was demonstrated by X-ray diffraction studies using synchrotron radiation. These studies showed the planar geometry for the coordinated mono(thiosemicarbazone) ligand and that the metal center can adopt either a heavily distorted tetrahedral Zn center (placed in an N/S/S/N environment, with CN = 4) or a pseudo-octahedral geometry, where the Zn(II) center is in the O/N/S/S/N/O environment, and CN = 6. Furthermore, 2-(4,5-dimethyl-2-thiazolyl)-3,5-diphenyl-2 H -tetrazolium bromide (MTT) assays and cellular imaging in living cells were subsequently performed in two different cancer cell lines: PC-3 (a standard cell line derived from a bone metastasis of a stage IV prostate cancer) and EMT6 (a commercial murine mammary carcinoma cell line). The radiolabeling of new functional and aromatic monothiosemicarbazones with either gallium-68 (under pH control) or fluorine-18 is discussed. The potential of this class of compounds to act as synthetic scaffolds for molecular imaging agents of relevance to positron emission tomography was evaluated in vitro , and the cellular uptake of a simultaneously fluorinated and [ 68 Ga]-labeled mono(thiosemicarbazone) was investigated and is reported here.

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Hydrothermal synthesized delafossite CuGaO2 as an electrocatalyst for water oxidation

Gao

Yang

Liu

et al. 2022

Front. Optoelectron.

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Hydrogen production from water splitting provides an effective method to alleviate the ever-growing global energy crisis. In this work, delafossite CuGaO2 (CGO) crystal was synthesized through hydrothermal routes with Cu(NO3)2·3H2O and Ga(NO3)3·xH2O used as reactants. The addition of cetyltrimethylammonium bromide (CTAB) was found to play an important role in modifying the morphology of CuGaO2 (CGO-CTAB). With the addition of CTAB, the morphology of CGO-CTAB samples changed from irregular flake to typical hexagonal sheet microstructure, with an average size of 1–2 μm and a thickness of around 100 nm. Furthermore, the electrocatalytic activity of CGO-CTAB crystals for oxygen evolution reaction (OER) was also studied and compared with that of CGO crystals. CGO-CTAB samples exhibited better activity than CGO. An overpotential of 391.5 mV was shown to be able to generate a current density of 10 mA/cm2. The as-prepared samples also demonstrate good stability for water oxidation and relatively fast OER kinetics with a Tafel slope of 56.4 mV/dec. This work highlights the significant role of modification of CTAB surfactants in preparing CGO related crystals, and the introduction of CTAB was found to help to improve their electrocatalytic activity for OER. Graphical abstract

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Radio- and nano-chemistry of aqueous Ga(iii) ions anchored onto graphene oxide-modified complexes

Abstract: The non-covalent radiolabelling of new graphene oxide-bis(thiosemicarbazonato) nanohybrids with gallium-68 and zirconium-89 ions is reported herein for the first time.

Cited by 11 publications

References 33 publications

Radiolabelling of nanomaterials for medical imaging and therapy

Radiolabelling of nanomaterials for medical imaging and therapy

Functional, Aromatic, and Fluorinated Monothiosemicarbazones: Investigations into Their Structures and Activity toward the Gallium-68 Incorporation by Microwave Irradiation

Hydrothermal synthesized delafossite CuGaO2 as an electrocatalyst for water oxidation

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