“Radical” Link Between Chronic Obstructive Pulmonary Disease and Cardiovascular Disease?

Guzik, Tomasz J.; Grodzicki, Tomasz

doi:10.1161/hypertensionaha.113.02623

Cited by 6 publications

(4 citation statements)

References 11 publications

(16 reference statements)

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“…Although the exact factors underlying excessive reactive oxygen species within skeletal muscle in COPD are not entirely clear (42), fiber type shifting could also play a considerable role in this respect given that type II fibers are characterized by greater production and lower scavenging of reactive oxygen species compared with type I fibers (40). In addition, the possibility exists that chronic lung inflammation characteristic of COPD evokes systemic responses that culminate in both peripheral oxidative stress and vascular inflammation (22). One prominent common pathophysiological consequence is impaired endothelium-dependent vasodilation consequent to reduced nitric oxide bioavailability (7,50).…”

Section: Discussionmentioning

confidence: 99%

Oxygen delivery-utilization mismatch in contracting locomotor muscle in COPD: peripheral factors

Medeiros

Fernandes

Azevedo

et al. 2015

American Journal of Physiology-Regulatory, Integrative and Comp

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Central cardiorespiratory and gas exchange limitations imposed by chronic obstructive pulmonary disease (COPD) impair ambulatory skeletal muscle oxygenation during whole body exercise. This investigation tested the hypothesis that peripheral factors per se contribute to impaired contracting lower limb muscle oxygenation in COPD patients. Submaximal neuromuscular electrical stimulation (NMES; 30, 40, and 50 mA at 50 Hz) of the quadriceps femoris was employed to evaluate contracting skeletal muscle oxygenation while minimizing the influence of COPD-related central cardiorespiratory constraints. Fractional O₂ extraction was estimated by near-infrared spectroscopy (deoxyhemoglobin/myoglobin concentration; deoxy-[Hb/Mb]), and torque output was measured by isokinetic dynamometry in 15 nonhypoxemic patients with moderate-to-severe COPD (SpO2 = 94 ± 2%; FEV₁ = 46.4 ± 10.1%; GOLD II and III) and in 10 age- and gender-matched sedentary controls. COPD patients had lower leg muscle mass than controls (LMM = 8.0 ± 0.7 kg vs. 8.9 ± 1.0 kg, respectively; P < 0.05) and produced relatively lower absolute and LMM-normalized torque across the range of NMES intensities (P < 0.05 for all). Despite producing less torque, COPD patients had similar deoxy-[Hb/Mb] amplitudes at 30 and 40 mA (P > 0.05 for both) and higher deoxy-[Hb/Mb] amplitude at 50 mA (P < 0.05). Further analysis indicated that COPD patients required greater fractional O₂ extraction to produce torque (i.e., ↑Δdeoxy-[Hb/Mb]/torque) relative to controls (P < 0.05 for 40 and 50 mA) and as a function of NMES intensity (P < 0.05 for all). The present data obtained during submaximal NMES of small muscle mass indicate that peripheral abnormalities contribute mechanistically to impaired contracting skeletal muscle oxygenation in nonhypoxemic, moderate-to-severe COPD patients.

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Section: Discussionmentioning

confidence: 99%

Oxygen delivery-utilization mismatch in contracting locomotor muscle in COPD: peripheral factors

Medeiros

Fernandes

Azevedo

et al. 2015

American Journal of Physiology-Regulatory, Integrative and Comp

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“…These; however, are involved in the inflammatory process, in turn, lead to the increase of local inflammatory expression that evokes systemic responses to search for patients with acute coronary syndromes and the levels of CRP and ADPN, verified high serum levels of CRP (p<0.05). In relation ADPN and CRP entered in high serum level of CRP is related to low values (ADPN p<0,001) 12,16,19 .…”

Section: Resultsmentioning

confidence: 86%

“…The FEV1 is a strong indicator of lung function. Thus, the analysis of pulmonary function in individuals with cardiovascular and respiratory impairment, which demonstrates the connection between the pulmonary dysfunction and the aspect of chronic inflammation 5,7,19 .…”

Section: Resultsmentioning

confidence: 99%

Relação Entre O Nível De Adiponectina Com Medidas Antropométricas E Respiratórias De Pacientes Submetidos À Cirurgia De Revascularização Miocárdica.

Araujo¹,

Souza²,

Santana³

et al. 2019

Revista E-Ciência

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RESUMOOs baixos níveis de adiponectina no plasma tem relação com o aumento da mortalidade em pacientes com doenças cardiovasculares, alterações da função pulmonar, sugerindo ação pró-inflamatória em decorrência da obesidade. Foram avaliados 65 pacientes, submetidos à cirurgia de revascularização do miocárdio. Analisados nível sérico da adiponectina, medidas antropométricas e respiratórias. Verificou-se que 55,8% dos pacientes do sexo masculino e 40% do feminino apresentaram sobrepeso e um IMC médio de 28,10 kg/m². Os maiores índices de sobrepeso foram verificados na faixa etária de 40 a 59 anos (62,5%) e de 60 anos ou mais (47,8%) O teste de comparação de proporção foi significativo para sexo (p=0,004), idade (p<0,001) e IMC (p=0,007). Quanto aos níveis de adiponectina verificou-se maior média no grupo masculino (média = 4,29), entre 40 a 59 anos (média = 4,70), com sobrepeso (média=4,70). Não houve relação entre o nível de adiponectina com as medidas antropométricas e respiratórias de pacientes submetidos à cirurgia de revascularização miocárdica.Palavras chaves: índice de massa corporal, adiponectina, antropometria, revascularização miocárdica. ABSTRACTLow plasma adiponectin levels are associated with increased mortality in patients with cardiovascular disease, changes of pulmonary function, suggesting that pro-inflammatory action as a result of obesity. We evaluated 65 patients submitted to myocardial revascularization surgery. Analyzed serum level of adiponectin, anthropometric and respiratory measures. It was verified that 55.8% of the male patients and 40% of the female patients were overweight and had an average BMI of 28.10 kg / m². The highest rates of overweight were found in the age group of 40-59 years old (62.5%) and 60 or older (47.8%). The proportion-comparison test was significant for gender (p = 0.004), age (p <0.001) and BMI (p = 0.007). Adiponectin levels were higher in the male group (average = 4.29), between 40 and 59 years old (average = 4.70), overweight (average = 4.70). There was no relationship between the level of adiponectin and the anthropometric and respiratory measurements of patients undergoing myocardial revascularization surgery.

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“… 2 , 7 , 18 Local inflammation in respiratory airways induces the over production of reactive oxygen species, chemokines, and cytokines which evoke a systemic perturbation that reduces nitric oxide bioavailability and contributes to systemic vascular dysfunction. 18 , 27 In fact, the degree of endothelial impairment is not only related with disease severity assessed by FEV 1 (% predicted), but is also associated with a worse overall prognosis. 2 , 17 , 28 In an effort to control for the impact of pulmonary exacerbation throughout the present investigation, it is important to emphasize that no changes in pulmonary function were observed in the patients across the multiple testing sessions.…”

Section: Discussionmentioning

confidence: 99%

Assessments of endothelial function and arterial stiffness are reproducible in patients with COPD

Rodriguez‐Miguelez

Seigler

Bass

et al. 2015

COPD

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BackgroundElevated cardiovascular disease risk is observed in patients with COPD. Non-invasive assessments of endothelial dysfunction and arterial stiffness have recently emerged to provide mechanistic insight into cardiovascular disease risk in COPD; however, the reproducibility of endothelial function and arterial stiffness has yet to be investigated in this patient population.ObjectivesThis study sought to examine the within-day and between-day reproducibility of endothelial function and arterial stiffness in patients with COPD.MethodsBaseline diameter, peak diameter, flow-mediated dilation, augmentation index, augmentation index at 75 beats per minute, and pulse wave velocity were assessed three times in 17 patients with COPD (six males, eleven females, age range 47–75 years old; forced expiratory volume in 1 second =51.5% predicted). Session A and B were separated by 3 hours (within-day), whereas session C was conducted at least 7 days following session B (between-day). Reproducibility was assessed by: 1) paired t-tests, 2) coefficients of variation, 3) coefficients of variation prime, 4) intra-class correlation coefficient, 5) Pearson’s correlations (r), and 6) Bland–Altman plots. Five acceptable assessments were required to confirm reproducibility.ResultsSix out of six within-day criteria were met for endothelial function and arterial stiffness outcomes. Six out of six between-day criteria were met for baseline and peak diameter, augmentation index and pulse wave velocity, whereas five out of six criteria were met for flow-mediated dilation.ConclusionThe present study provides evidence for within-day and between-day reproducibility of endothelial function and arterial stiffness in patients with COPD.

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“Radical” Link Between Chronic Obstructive Pulmonary Disease and Cardiovascular Disease?

Cited by 6 publications

References 11 publications

Oxygen delivery-utilization mismatch in contracting locomotor muscle in COPD: peripheral factors

Oxygen delivery-utilization mismatch in contracting locomotor muscle in COPD: peripheral factors

Relação Entre O Nível De Adiponectina Com Medidas Antropométricas E Respiratórias De Pacientes Submetidos À Cirurgia De Revascularização Miocárdica.

Assessments of endothelial function and arterial stiffness are reproducible in patients with COPD

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