Radiation-induced neoplasms of the brain

Kumar, Pradeep; Good, Roger R.; Skultety, F. Miles; Leibrock, Lyal G.; Severson, Gregory S.

doi:10.1002/1097-0142(19870401)59:7<1274::aid-cncr2820590708>3.0.co;2-h

Cited by 75 publications

(16 citation statements)

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“…Case reports present successful treatments of an example of bilateral blindness secondary to a recurrent, preirradiated hemangiopericytoma of the pituitary fossa [172], or of radiation-induced neoplasms [173]. Even a clival chordoma [174] and other skull base tumours [175,176] have been treated with an implantation of seeds, as well as locations that are a challenge for high-precision percutaneous radiotherapy [177,178].…”

Section: Reviewmentioning

confidence: 99%

Iodine-125 brachytherapy for brain tumours - a review

et al. 2012

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Iodine-125 brachytherapy has been applied to brain tumours since 1979. Even though the physical and biological characteristics make these implants particularly attractive for minimal invasive treatment, the place for stereotactic brachytherapy is still poorly defined.An extensive review of the literature has been performed, especially concerning indications, results and complications. Iodine-125 seeds have been implanted in astrocytomas I-III, glioblastomas, metastases and several other tumour entities. Outcome data given in the literature are summarized. Complications are rare in carefully selected patients.All in all, for highly selected patients with newly diagnosed or recurrent primary or metastatic tumours, this method provides encouraging survival rates with relatively low complication rates and a good quality of life.

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Section: Reviewmentioning

confidence: 99%

Iodine-125 brachytherapy for brain tumours - a review

et al. 2012

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“…Moreover, due to base pair disruption and deoxyribonucleic acid (DNA) strand alteration, irradiation can produce neoplastic transformation 12 . Tumour development within the irradiated field constitutes a known consequence with very detrimental outcome 13,14 .…”

Section: Discussionmentioning

confidence: 99%

“…Large series have shown that skull low dose irradiation (350-425cGy) for pediatric treatment of Tinea capitis increases the relative risk for developing a brain tumour by 2.6 times 18 . Likewise, malignant CNS tumours have been witnessed to evolve in animal models submitted to brain irradiation with proton or x-ray in a much higher frequency than in non-irradiated animals 13,[23][24][25] .…”

Section: Discussionmentioning

confidence: 99%

“…Radiation therapy can produce side effects such as tissue damage [4][5][6][7][8][9][10][11] and neoplastic transformation 1,12 in the irradiated field. Tumour development after radiotherapy is constantly described as an unusual but invariably serious medium term complication of irradiation 13,14 . For patients undergoing sellar irradiation, gliomas are the most frequent tumours, usually presented with marked aggressive behaviour and young age of onset 1,11 .…”

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Pilocytic astrocytoma following radiotherapy for craniopharyngioma: case report

Bonilha¹,

Borges

Fernandes

et al. 2000

Arq. Neuro-Psiquiatr.

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-Administration of fractionated doses of irradiation is part of the adjutant therapy for CNS tumours such as craniopharyngiomas and pituitary adenomas. It can maximise cure rates or expand symptom-free period. Among the adverse effects of radiotherapy, the induction of a new tumour within the irradiated field has been frequently described. The precise clinical features that correlate irradiation and oncogenesis are not completely defined, but some authors have suggested that tumors are radiation induced when they are histologically different from the treated ones, arise in greater frequency in irradiated patients than among normal population and tend to occur in younger people with an unusual aggressiveness. In this article, we report a case of a papillary astrocytoma arising in a rather unusual latency period following radiotherapy for craniopharyngioma.KEY WORDS: pilocytic astrocytoma, radiotherapy adverse-effects, oncogenesis. Astrocitoma pilocítico pós-radioterapia para tratamento de craniofaringioma: relato de casoRESUMO -A administração de doses fracionadas de radiação é parte do tratamento adjuvante de tumores do sistema nervoso central como craniofaringiomas ou adenomas hipofisários. A radioterapia pode aumentar as chances de cura ou expandir o período livre de sintomas. Dentre seus efeitos adversos, é conhecida a possibilidade de aparecimento de novo tumor na região irradiada. Os critérios que definem se um novo tumor é de fato induzido por radiação ainda não são completamente definidos. Adimite-se, no entanto, que se o novo tumor é histologicamente diferente do primeiro, aparece em indivíduos mais jovens e é mais agressivo que o habitual, provavelmente sua origem é devida à oncogênese da irradiação. Descrevemos um caso de astrocitoma pilocítico possivelmente induzido por radioterapia, com surgimento em tempo de latência inesperadamente curto. PALAVRAS-CHAVE: astrocitoma pilocítico, efeitos adversos de radioterapia, oncogênese.

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“…There are many reports of an excess of brain tumours following radiation exposure involving the head (Modan et al 1974, Shore et al 1976, Colman et al 1978, Waxweiler et al 1983, Schoenberg 1991, Dierssen et al 1988, Kumar et al 1987, including groups exposed to a-irradiation from thorium dioxide (Van Kaick et al 1986, Kyle et al 1963, radium (Stebbings and Semkiw 1989), nuclear fuel material (Hadjimichael et al 1983) and plutonium (Wilkinson et al 1987) . Excesses of brain tumours in these studies were often only marginally significant .…”

Section: Discussionmentioning

confidence: 99%

Incidence of Brain Tumours in Rats Exposed to an Aerosol of²³⁹PuO₂

Sanders

Dagle

Mahaffey

1992

International Journal of Radiation Biology

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Incidence of brain tumours was investigated in 3390 female and male Wistar rats exposed to an aerosol of 239PuO2, or as sham-exposed controls. Lung doses ranged from 0.05 to 22 Gy. In females, six brain tumours were found in 1058 control rats (incidence, 0.6%) and 24 brain tumours in 2134 rats exposed to Pu (incidence, 1.1%); the survival-adjusted level of significance was p = 0.29 for comparing control with exposed females. In males, two brain tumours were found in 60 control rats (incidence, 3.3%) and seven brain tumours in 138 rats exposed to Pu (incidence, 5.1%); the survival-adjusted level of significance was p = 0.33. Brain tumour incidence was about five times greater in male than in female rats (p = 0.0001), demonstrating a highly significant sex difference in brain tumour incidence. Tumour types were distributed similarly among control and Pu-exposed groups of both sexes; most tumours were astrocytomas. Mean lifespans for rats with brain tumours were not significantly different between control and Pu-exposed rats. Plutonium was not detected on autoradiograms of the brain. These results, like those for plutonium workers, show an increase of brain tumours which cannot be demonstrated statistically to be related to radiation exposure.

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Radiation-induced neoplasms of the brain

Cited by 75 publications

References 44 publications

Iodine-125 brachytherapy for brain tumours - a review

Iodine-125 brachytherapy for brain tumours - a review

Pilocytic astrocytoma following radiotherapy for craniopharyngioma: case report

Incidence of Brain Tumours in Rats Exposed to an Aerosol of²³⁹PuO₂

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Radiation-induced neoplasms of the brain

Cited by 75 publications

References 44 publications

Iodine-125 brachytherapy for brain tumours - a review

Iodine-125 brachytherapy for brain tumours - a review

Pilocytic astrocytoma following radiotherapy for craniopharyngioma: case report

Incidence of Brain Tumours in Rats Exposed to an Aerosol of239PuO2

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Incidence of Brain Tumours in Rats Exposed to an Aerosol of²³⁹PuO₂