Radiation-induced Extra-osseous Osteosarcoma—A Case Report and Review of Literature

Vikram, Syam; Salih, Surij; Krishnan, Aswathy S.; Nizamudheen, M. P.; Babu, Sajith; Aravind, Sithara; Sangeetha, N.; Sateesan, B.

doi:10.1007/s13193-013-0262-7

Cited by 2 publications

(2 citation statements)

References 20 publications

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“…The incidence rate of radiotherapy-associated ESOS is 3.8-10% of all ESOSs [16] and 13% of all radiation-induced sarcomas [30]. Most cases of osteosarcoma after radiation arise from skeletal structures, but radiation-induced osteosarcoma can be extraskeletal [31]. In 1948, Cahan et al [32] established four criteria for the diagnosis of radiation-induced osteosarcoma, which are still valid: (i) history of radiation therapy, (ii) sarcoma arising within the radiation field after the radiation has been given, (iii) long latency period, and (iv) histologic confirmation of the sarcoma.…”

Section: Discussionmentioning

confidence: 99%

Anal extraskeletal osteosarcoma in a man: a case report and review of the literature

et al. 2020

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Background: Osteosarcoma is a common malignancy of bone that usually occurs in individuals in the age range of 0-24 years. Extraskeletal osteosarcoma is a rare tumor presentation which originates in non-bony tissues. Extraskeletal osteosarcoma comprises 2-5% of all osteosarcomas and less than 1% of all soft tissue sarcomas. As compared to bone-derived osteosarcoma, extraskeletal osteosarcoma occurs in older age groups. Extraskeletal osteosarcoma has a poorer prognosis than bone osteosarcoma. To the best of our knowledge, this is the first case of extraskeletal osteosarcoma in the anal region. Case presentation: A 70-year-old Hazara man presented to a private hospital with the chief complaints of constipation, bloody defecation, and pain during defecation of 1.5 months' duration. His past history was unremarkable. A digital rectal examination showed a solid growth in the middle part of his anus. A colonoscopic examination was done and showed a solid mass in his anal region. A computed tomography scan revealed an irregular mural thickening in the anal canal with heterogeneous enhancement. The maximum length of the involved segment was measured to be 4.5 cm. No suspicious lesions were noted in other organs. An abdominoperineal resection was performed on our patient. A 22 cm in length resected segment of his colon, consisting of the lower sigmoid, rectum, and anus was sent to us for histopathological examination. Gross examination revealed a polypoid dark-gray tumor measuring 5 × 3 × 2 cm. The cut section revealed gray and white appearance with firm-to-hard consistency and foci of ossification. Microscopic examination revealed normal anorectal mucosa and a spindle cell malignant neoplasm with osteoid formations. No evidence of epithelial carcinoma was noted. Immunohistochemical stains were positive for stabilin-2 and negative for cytokeratin, which confirmed the diagnosis of osteosarcoma. Conclusion: Extraskeletal osteosarcoma of the colon is rare and presence of the tumor in the rectum and anal region is extremely rare. Radiology, colonoscopy, and histopathology with immunostaining are required for the diagnosis. The accurate diagnosis of extraskeletal osteosarcoma is important as it has a different regimen of treatment with poorer prognosis compared to primary osteosarcoma of the bone.

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Section: Discussionmentioning

confidence: 99%

Anal extraskeletal osteosarcoma in a man: a case report and review of the literature

et al. 2020

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“…Osteosarcoma is one of the most common highly malignant forms of bone tumors, occurring most frequently in children and adolescents, with a poor clinical prognosis (1)(2)(3). Amputation surgery is the primary treatment for patients with osteosarcoma, but confers a five-year survival rate of just 10-20% (4).…”

Section: Introductionmentioning

confidence: 99%

Therapeutic effect of lymphokine-activated killer cells treated with low-dose ionizing radiation on osteosarcoma

Zhao¹,

Lv²,

Sayimu³

et al. 2015

Oncology Letters

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Abstract. The aim of the present study was to investigate the effect of lymphokine-activated killer (LAK) cells, which received low-dose ionizing radiation, on the treatment of osteosarcoma in rats. The cultured UMR-106 cells were inoculated under the anterior chest skin of 24 rats to establish an osteosarcoma model. In addition, the LAK cells from 24 mice were exposed to doses of 0 (control group), 0.65 or 3.25 mGy X-ray radiation. The tritiated thymidine ( 3 H-TdR) release method and Winn assay were performed to determine the antitumor effects of the LAK cells. The proliferation of the mouse LAK cells treated with 3.25 mGy radiation was significantly higher than that for those treated with 0 or 0.65 mGy radiation, which suggested that low-dose ionizing radiation stimulates the proliferation of LAK cells. The tumor-bearing rats were divided into three groups and injected with LAK cells that had already received 0, 0.65 or 3.25 mGy radiation. The mean survival time of the 3.25-mGy group was longer than that of the 0-and 0.65-mGy groups. After 30 days, tumors with weights of ~6.25 and 2.0 g were identified in the rats of the 0-and 0.65-mGy groups, respectively. However, tumor proliferation was not detectable in the rats of the 3.25-mGy radiation group. Therefore, low-dose ionizing radiation effectively kills osteosarcoma cells in rats by stimulating the proliferation and enhancing the cytotoxicity of LAK cells.

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Radiation-induced Extra-osseous Osteosarcoma—A Case Report and Review of Literature

Cited by 2 publications

References 20 publications

Anal extraskeletal osteosarcoma in a man: a case report and review of the literature

Anal extraskeletal osteosarcoma in a man: a case report and review of the literature

Therapeutic effect of lymphokine-activated killer cells treated with low-dose ionizing radiation on osteosarcoma

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