Radiation Effects on Testes: XII. Monovalent Electrolytes in Relation to Radiation Injury of Germinal Epithelium

Biological damage in testis by Iodine-125 in partially blocked thyroid of rats

“…Biochemical lesions in DNA, RNA, acid phosphatase, total ATPase and Na/K dependent ATPase of rat testis have been demonstrated in our earlier investigations [9,11,12]. It has been suggested that radiation damage to testicular cells is not only due to the direct inhibition of mitosis and DNA synthesis, but is also caused by interaction of gamma photons with plasma membrane, which may result in the imbalance of sodium and potassium in radiosensitive germinal cells [9,14]. A similar situation seems to occur following intraperitoneally administered iodine-125.…”

“…Damage to testis by iodine-125 seems to be similar in many ways to the damage caused by high LET radiation exposures [5,[9][10][11][12][13][14]. For example, in order of increasing radiosensitivity, A 1--A4 spermatogonia are most sensitive to X and F-irradiation in tubular elements [5,13].…”

“…Methods for estimation of nucleic acids [12], acid phosphatase [10], adenosine-triphosphatase (ATPase) [9,11,14], sodium and potassium have been reported earlier. A portion of testis was fixed in Bouins fluid for histological studies.…”