2007
DOI: 10.1152/ajpcell.00322.2006
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RACK1 is a BKCa channel binding protein

Abstract: Isacson CK, Lu Q, Karas RH, Cox DH. RACK1 is a BKCa channel binding protein. Am J Physiol Cell Physiol 292: C1459 -C1466, 2007. First published January 31, 2006; doi:10.1152/ajpcell.00322.2006.-The large conductance calcium-activated potassium channel, or BKCa channel, plays an important feedback role in a variety of physiological processes, including neurotransmitter release and smooth muscle contraction. Some reports have suggested that this channel forms a stable complex with regulators of its function, inc… Show more

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Cited by 24 publications
(17 citation statements)
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“…These data largely validate a previous study showing an interaction between Slo and Rack1 by yeast two-hybrid experiments (24). That study demonstrated the functional effects of its association with Rack1 on the biophysical properties of Slo.…”
Section: Discussionsupporting
confidence: 91%
“…These data largely validate a previous study showing an interaction between Slo and Rack1 by yeast two-hybrid experiments (24). That study demonstrated the functional effects of its association with Rack1 on the biophysical properties of Slo.…”
Section: Discussionsupporting
confidence: 91%
“…RACK1 can bind BK Ca channel and is thought to impair its function [56]. Therefore, we next investigated the expression of RACK1 protein in mesenteric arteries from DOCA-salt and Uni rats (Fig.…”
Section: Resultsmentioning
confidence: 99%
“…In addition, an interesting study showed that RACK1 slowed the activation of the channel in Xenopus oocytes (53). VDAC2, an ion channel component, is involved in the release of cytochrome c during IBDV infection (25).…”
Section: Discussionmentioning
confidence: 99%