Racial or Familial Anemia of Children

Porotic hyperostosis: New evidence to support the anemia theory

“…Histologic examination of a clinical case of hemolytic anemia by Whipple and Bradford (1932) showed a very cellular marrow with large marrow spaces and a thinned or absent outer table. Middlemiss (1961) described the histology of a case of sickle cell anemia where there was thinning of trabeculae which were packed with active erythropoietic tissue.…”

Bayes' theorem in paleopathological diagnosis

“…The final complication affecting prevalences are intrinsic and extrinsic population factors that influence the rate at which persons will suffer pathological conditions. For example, the frequency of genetically induced diseases such as sickle‐cell anemia and thalassemia, which can have osteological manifestations (Cooley et al, 1927; Sebes and Diggs, 1979; Whipple and Bradford, 1932), would cause prevalences in some areas of the world to be different from those in other areas. Similarly, environmental factors such as climate and weather, which long have been recognized to be correlated with the appearance of diseases and often are seen to be related to seasonality (Yan, 2000; De Garine, 1993; Lukacs and Walimbe, 1998; Steinbock, 1976; Ortner and Putschar, 1981; Aufderheide and Rodríguez‐Martin, 1998), also make the calculation of this statistic dependent on geographic location.…”

Cooley's Anaemia in a Maltese Child

“…Furthermore, the pigment distribution is entirely different, and although iron-positive material may be found in the heart, thyroid, and gastric musosa in long-standing cases, the greatest accumulation occurs in the spleen and, to a lesser extent, in the Kuppfer cells of the liver (Whipple and Bradford, 1932). This disparity in the quantity of splenic pigment found in these two familial, haemolytic >| ; anaemias can be at least partially rationalized by a 9 1 consideration of the physiological action of the spleen upon the morphology of erythrocytes.…”