Racial disparities disruptive genes in prostate carcinogenesis

Abstract

Introduction 3. Genetic variations in prostate cancer leading to disparities 3.1. Genetic heterogeneity in AR CAG repeat length and racial variation 3.2. Ribonuclease 4 or 2'-5' oligoadenylate synthetase-dependent ribonuclease (RNase L) 3.3. The macrophage scavenger receptor 1 (MSR1): 3.4. Androgen metabolism and CYP genetic variants 3.5. Differential expression of regulatory microRNAs 3.6. Single Nucleotide Polymorphism (SNP) in miRNA regulation 4. Diet, obesity, and metabolism related disparities in context to prostate cancer 5. Disparities in factors influencing tumor microenvironment in prostate cancer 5.1. Stromal microenvironment in disparity 6. Epigenetics as racial disparity 7. Conclusions 8. Future perspective 9. Acknowledgements 10. References