Racial Discrimination, Mental Health, and Parenting Among African American Mothers of Preschool-Aged Children

Condon, Eileen M.; Barcelona, Veronica; Ibrahim, Bridget Basile; Crusto, Cindy A.; Taylor, Jacquelyn Y.

doi:10.1016/j.jaac.2021.05.023

Cited by 24 publications

(23 citation statements)

References 48 publications

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“…In that study, authors suggest that improved parenting support for individuals experiencing traumatic experiences may reduce the risk of poor outcomes in children resulting from poor postpartum mental health, lower confidence as a parent, and maladaptive coping [ 32 ]. Indeed, several studies have observed a significant association between ACEs and parenting stress [ 33 , 34 , 35 , 36 ] and we documented the link between parenting stress and DNAm in previous analyses in this sample [ 37 , 38 ]. Further research attending to both the biological and socioecological mechanisms of intergenerational effects on methylation can elucidate these relationships.…”

Section: Discussionsupporting

confidence: 73%

Experiences of Trauma and DNA Methylation Profiles among African American Mothers and Children

Barcelona

Huang

Caceres

et al. 2022

IJMS

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Potentially traumatic experiences have been associated with chronic diseases. Epigenetic mechanisms, including DNA methylation (DNAm), have been proposed as an explanation for this association. We examined the association of experiences of trauma with epigenome-wide DNAm among African American mothers (n = 236) and their children aged 3–5 years (n = 232; N = 500), using the Life Events Checklist-5 (LEC) and Traumatic Events Screening Inventory—Parent Report Revised (TESI-PRR). We identified no DNAm sites significantly associated with potentially traumatic experience scores in mothers. One CpG site on the ENOX1 gene was methylome-wide-significant in children (FDR-corrected q-value = 0.05) from the TESI-PRR. This protein-coding gene is associated with mental illness, including unipolar depression, bipolar, and schizophrenia. Future research should further examine the associations between childhood trauma, DNAm, and health outcomes among this understudied and high-risk group. Findings from such longitudinal research may inform clinical and translational approaches to prevent adverse health outcomes associated with epigenetic changes.

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Section: Discussionsupporting

confidence: 73%

Experiences of Trauma and DNA Methylation Profiles among African American Mothers and Children

Barcelona

Huang

Caceres

et al. 2022

IJMS

Self Cite

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show abstract

“…Yet their limited representation in genomics research continues to deny them potential benefits of such research [ 69 , 70 ]. Furthermore, it diminishes our ability to study whether and how population genomic effects interact with social determinants of health and discrimination as contributors to disparities in mortality [ 71 , 72 ]. While the present study has limitations related to inclusion and representation, we are investigating approaches to adequately power research among trans-ethnic cohorts as next steps.…”

Section: Discussionmentioning

confidence: 99%

Sex-dimorphic gene effects on survival outcomes in people with coronary artery disease

Dungan

Qin

Gregory

et al. 2022

American Heart Journal Plus: Cardiology Research and Practice

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“…Other InterGEN analyses have also demonstrated the importance of chronic stressors such as neighborhood stress and experiencing racial discrimination and how exposure to such stressors negatively impact mental and physical health. 53 - 55…”

Section: Discussionmentioning

confidence: 99%

Stress Overload and DNA Methylation in African American Women in the Intergenerational Impact of Genetic and Psychological Factors on Blood Pressure Study

et al. 2022

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Introduction: Experiencing psychosocial stress is associated with poor health outcomes such as hypertension and obesity, which are risk factors for developing cardiovascular disease. African American women experience disproportionate risk for cardiovascular disease including exposure to high levels of psychosocial stress. We hypothesized that psychosocial stress, such as perceived stress overload, may influence epigenetic marks, specifically DNA methylation (DNAm), that contribute to increased risk for cardiovascular disease in African American women. Methods: We conducted an epigenome-wide study evaluating the relationship of psychosocial stress and DNAm among African American mothers from the Intergenerational Impact of Genetic and Psychological Factors on Blood Pressure (InterGEN) cohort. Linear mixed effects models were used to explore the epigenome-wide associations with the Stress Overload Scale (SOS), which examines self-reported past-week stress, event load and personal vulnerability. Results: In total, n = 228 participants were included in our analysis. After adjusting for known epigenetic confounders, we did not identify any DNAm sites associated with maternal report of stress measured by SOS after controlling for multiple comparisons. Several of the top differentially methylated CpG sites related to SOS score ( P < 1 × 10−5), mapped to genes of unknown significance for hypertension or heart disease, namely, PXDNL and C22orf42. Conclusions: This study provides foundational knowledge for future studies examining epigenetic associations with stress and other psychosocial measures in African Americans, a key area for growth in epigenetics. Future studies including larger sample sizes and replication data are warranted.

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Racial Discrimination, Mental Health, and Parenting Among African American Mothers of Preschool-Aged Children

Cited by 24 publications

References 48 publications

Experiences of Trauma and DNA Methylation Profiles among African American Mothers and Children

Experiences of Trauma and DNA Methylation Profiles among African American Mothers and Children

Sex-dimorphic gene effects on survival outcomes in people with coronary artery disease

Stress Overload and DNA Methylation in African American Women in the Intergenerational Impact of Genetic and Psychological Factors on Blood Pressure Study

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