Racial and Ethnic Disparities in Research and Clinical Trials

Syder, Nicole; Elbuluk, Nada

doi:10.1016/j.det.2022.10.007

Cited by 4 publications

(5 citation statements)

References 27 publications

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“…Laser and laser-assisted drug delivery have risen in popularity for the treatment of melasma and hyperpigmentation. 10…”

Section: Resultsmentioning

confidence: 99%

“…Melasma and hyperpigmentation are dermatologic conditions commonly seen in SPT III-VI that can arise in a variety of settings. 10 Facial hyperpigmentation can cause significant psychosocial burden due to the high visibility of this area. Laser and laser-assisted drug delivery have risen in popularity for the treatment of melasma and hyperpigmentation.…”

Section: Melasma and Hyperpigmentationmentioning

confidence: 99%

“…Laser and laser-assisted drug delivery have risen in popularity for the treatment of melasma and hyperpigmentation. 10 Based on the results of the 10 studies shown in Supplemental Digital Content 1, Table 2, http://links.lww. com/DSS/B380, nonablative lasers are both safe and effective for treatment in melasma and hyperpigmentation up to SPT V. Nine studies examined the use of NAFL in facial melasma, whereas 1 study specifically looked at hyperpigmented scars.…”

Section: Melasma and Hyperpigmentationmentioning

confidence: 99%

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Review of Fractional Nonablative Lasers for the Treatment of Dermatologic Conditions in Darker Skin Phototypes

Aggarwal,

Rossi,

Puyana

et al. 2024

Dermatol Surg

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BACKGROUND Fractional nonablative lasers (NAFLs) have demonstrated efficacy and safety for treating dermatologic conditions in patients with darker skin phototypes. Nonablative lasers are preferred in darker skin tones due to lower risk of postinflammatory hyperpigmentation. OBJECTIVE This review aims to identify the ideal laser options and parameters for treating common dermatologic conditions in patients with skin types IV-VI. MATERIALS AND METHODS A comprehensive literature search was conducted on PubMed in May 2023. Of 1,065 articles were identified, and 40 articles met the inclusion criteria. The studies were classified based on design, dermatologic condition, and skin phototype of patients, and assigned levels of evidence according to the Modified Criteria of the Oxford Center of Evidence Based Medicine. RESULTS Strong level 1 evidence supports the treatment of melasma and atrophic scars using NAFL. Moderate level 2 evidence was found for using NAFL in acne vulgaris, striae, and skin rejuvenation; 45% of the studies examined skin types III-IV, 20% III-V, 7.5% II-IV, 5% II-V, 5% IV alone, and 2.5% I-IV. CONCLUSION Further research is needed to determine the optimal treatment modalities and parameters for skin types V and VI. Appropriate device selection and conservative treatment settings are crucial for optimizing outcomes and minimizing adverse events.

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“…Laser and laser-assisted drug delivery have risen in popularity for the treatment of melasma and hyperpigmentation. 10…”

Section: Resultsmentioning

confidence: 99%

Section: Melasma and Hyperpigmentationmentioning

confidence: 99%

Section: Melasma and Hyperpigmentationmentioning

confidence: 99%

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Review of Fractional Nonablative Lasers for the Treatment of Dermatologic Conditions in Darker Skin Phototypes

Aggarwal,

Rossi,

Puyana

et al. 2024

Dermatol Surg

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“…However, overproduction and buildup of melanin can lead to various skin pigment irregularities, such as solar lentigines (SL), flat seborrheic keratosis (SK), melasma, freckles, and post‐inflammatory hyperpigmentation 1,2 . Typically, these pigmentation disorders manifest between the ages of 20 to 40, occurring more frequently in individuals with Fitzpatrick skin types III or IV 3 . Notably, among Asian women, pigmentary irregularities appear with increased severity and at an earlier life stage compared to French women 4 .…”

Section: Introductionmentioning

confidence: 99%

Skin dark spot mapping and evaluation of brightening product efficacy using Line‐field Confocal Optical Coherence Tomography (LC‐OCT)

Jdid,

Pedrazzani,

Lejeune

et al. 2024

Skin Research and Technology

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BackgroundFacial dark spots remain a significant challenge for the cosmetic industry, in terms of providing effective treatment. Using Line‐field Confocal Optical Coherence Tomography (LC‐OCT), we investigated the internal structural features of photo‐aging spot areas and evaluated the efficacy of a skin‐brightening cosmetic product.Materials and MethodsTwenty‐six Asian female volunteers, aged between 29 and 65 years, applied a cosmetic product on their entire face twice a day for 2 months. LC‐OCT was used to evaluate the dermal‐epidermal junction (DEJ) undulation and the volume density of melanin in the epidermis at D0 and D56. Skin brightening and redness were also assessed by photography (SkinCam).ResultsUsing LC‐OCT technology, various microscopic dark spot morphologies, spanning from minimally deformed DEJ to complex DEJ patterns, were identified. Dark spots characterized by slight deformities in the DEJ were predominantly observed in the youngest age group, while older volunteers displayed a wavier pattern. Furthermore, a total of 44 spots were monitored to evaluate the brightening product efficacy. A statistically significant reduction in melanin volumetric density of 7.3% in the spots and 12.3% in their surrounding area was observed after 56 days of product application. In line with these results, an analysis of color parameters using SkinCam reveals a significant increase in brightening and decrease in redness in both pigmented spots and the surrounding skin following application.ConclusionsLC‐OCT proves to be a valuable tool for in‐depth dark spots characterization and assessment of skin brightening products, enabling various applications in the field of dermatological sciences.

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“…Hyperpigmentation of the skin is a prevalent dermatologic condition whereby the colour of the skin turns darker due to a deposition of melanin in the epidermis or the dermis. 1,2 This cutaneous alteration in colour is brought about by many internal or external factors which can include UV exposure, inflammation and hormonal changes. 1,3,4 Based on the extent and location of the skin coloration, quality of life can be greatly affected and patients can experience significant psychological burden.…”

Section: Introductionmentioning

confidence: 99%

A Bayesian network meta‐analysis of 14 molecules inhibiting UV daylight‐induced pigmentation

Muller,

Flament,

Jouni

et al. 2024

Acad Dermatol Venereol

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IntroductionHyperpigmentation disorders are very frequent, affect the quality of life and may become a psychological burden for afflicted patients. Many anti‐pigmenting or depigmenting agents are available with various efficacy and almost no comparative data. 2‐mercaptonicotinoyl glycine (2‐MNG) was recently proposed as a viable candidate showing safe and effective results on hyperpigmentation control in vitro and in vivo.ObjectivesA Bayesian network meta‐analysis (BNMA) was conducted to map and rank the anti‐pigmenting and depigmenting efficacy of 2‐MNG 0.5% on UV daylight (UVDL)‐induced pigmentation together with 13 other reference molecules. A comparison in the kinetics of 2‐MNG 0.5% was also performed.MethodologyFourteen studies were conducted, for each, on 15–30 women of skin phototype III in Shanghai, China and Paris, France. The products were applied on mini zone, in randomized and blinded protocol, on the back, 5 days a week during 6 weeks, at a dose of 4 mg/cm2. During the second week, volunteers were exposed under to varying minimum erythemal dose of UVDL during 4 consecutive days—adapted to obtain a similar induction of skin pigmentation regardless of the population. Assessments were performed instrumentally using Chromameter®. Ascorbic acid 7% was used as a positive control for all experiments. A Bayesian network meta‐analysis was then established to map and follow the kinetics of 2‐MNG 0.5% performance with 13 reference molecules (glutathione 2%, kojic acid 1%, hydroquinone 4%, ascorbyl glucoside 2%, niacinamide 4%, etc.).Results2‐MNG 0.5% dominated the ranking at all time points with a significant high probability of strong efficacy against UVDL‐induced pigmentation. Ascorbic acid 7% ranks second after 4 days of irradiations (D12) whereas hydroquinone 4% ranks second 1 month after irradiations (D40). In the kinetics, 2‐MNG at 0.5% was effective as from the end of irradiations (D12) to the study endpoint (D40). This suggested an immediate and persistent efficacy across all timepoints evaluated.ConclusionThe BNMA revealed a rapid and lasting efficacy of 2‐MNG 0.5% on the anti‐pigmenting and depigmenting phases of the clinical protocol. 2‐MNG 0.5% ranked first, with immediate and lasting effect compared to 13 other references. This study is the first allowing comparison between reference anti‐pigmenting and depigmenting agents and will help clinicians for proposing the most effective approach for their patients.

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Racial and Ethnic Disparities in Research and Clinical Trials

Cited by 4 publications

References 27 publications

Review of Fractional Nonablative Lasers for the Treatment of Dermatologic Conditions in Darker Skin Phototypes

Review of Fractional Nonablative Lasers for the Treatment of Dermatologic Conditions in Darker Skin Phototypes

Skin dark spot mapping and evaluation of brightening product efficacy using Line‐field Confocal Optical Coherence Tomography (LC‐OCT)

A Bayesian network meta‐analysis of 14 molecules inhibiting UV daylight‐induced pigmentation

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