Rabies Encephalitis: A Disease Characterized By Complex Neuropathogenic Pathways and Diagnostic Difficulties

Hassaan, Sadia; Firoze, Safiya; Raza, Adil; Sami, Hiba; Ahmad, Siraj

doi:10.1007/978-981-99-6445-1_10

Viral and Fungal Infections of the Central Nervous System: A Microbiological Perspective 2023

DOI: 10.1007/978-981-99-6445-1_10

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Rabies Encephalitis: A Disease Characterized By Complex Neuropathogenic Pathways and Diagnostic Difficulties

Sadia Hassaan,

Safiya Firoze,

Adil Raza

et al.

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2024

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Cited by 1 publication

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Difficulties in diagnosing rabies using the example of a clinical case in the Omsk region

Puzyreva,

Poleshchuk,

Bardina

et al. 2024

Epidemiology and Infectious Diseases

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Rabies is the deadliest zoonotic disease caused by the rabies virus, a member of the genus Lyssavirus. The disease occurs after a bite from a wild or domestic animal.The team of authors presents a clinical case of rabies with the difficulties of early diagnosis of the disease in a patient suffering from alcoholism, features of clinical, epidemiological and laboratory diagnostics. The victim sought medical help 20 days after the dog bite. On day 20, a hydrophobia clinic was observed. Signs of visual and auditory hallucinations, aggressiveness, and disorientation in place and time appeared, which resembled the development of alcoholic psychosis. When testing saliva samples collected on the 3rd day of the disease with PCR for the rabies virus, a negative result was obtained. On the 29th day, the patient died. The diagnosis of rabies was confirmed antemortem and posthumously. The virus was detected in saliva on the 9th day of the disease and posthumously in the cerebral cortex, medulla oblongata, cerebellum, and salivary glands. Histologically, Bebesh-Negri bodies were found in the brain tissue. The necessary preventive measures were carried out in full.The unfavorable outcome in the described case of rabies emphasizes the lack of awareness of the population (especially rural) about the risk of contracting rabies infection through contact with animals and the importance of timely post-exposure prophylaxis. Timely anti-rabies care remains the only effective means of preventing deaths from this disease.

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Difficulties in diagnosing rabies using the example of a clinical case in the Omsk region

Puzyreva,

Poleshchuk,

Bardina

et al. 2024

Epidemiology and Infectious Diseases

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show abstract

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Rabies Encephalitis: A Disease Characterized By Complex Neuropathogenic Pathways and Diagnostic Difficulties

Cited by 1 publication

References 52 publications

Difficulties in diagnosing rabies using the example of a clinical case in the Omsk region

Difficulties in diagnosing rabies using the example of a clinical case in the Omsk region

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